Trauma-informed interventions versus control for cancer-risk behaviours among adults: rationale and design for a randomized trial

Currie, Cheryl L.; Copeland, Jennifer L.; Voss, M. Lauren; Swanepoel, Lisa-Marie; Ambeskovic, Mirela; Patel, Nimesh B.; Higa, Erin K.

doi:10.1186/s12889-019-7641-0

Table 2 Study biomarkers

From: Trauma-informed interventions versus control for cancer-risk behaviours among adults: rationale and design for a randomized trial

Biomarkers	Source	Function	Measurement Procedure	Analysis
1. Immune
CRP	Saliva	Inflammatory marker.	Passive drool method^a	Lab analysis^b
Secretory IgA	Saliva	Immune function of mucous membranes.	Passive drool	Lab analysis
IL-1β	Saliva	Pro-inflammatory cytokine	Passive drool	Lab analysis
IL-6	Saliva	Pro- and anti-inflammatory cytokine	Passive drool	Lab analysis
IL-8	Saliva	Pro-inflammatory cytokine	Passive drool	Lab analysis
TNF α	Saliva	Pro-inflammatory cytokine	Passive drool	Lab analysis
2. Neuroendocrine
DHEA-S	Saliva	Stress-response marker	Passive drool	Lab analysis
3. Metabolic
BMI		Health-risk indicator for cardiometabolic disease	Height and weight will be measured once, to the nearest 0.5 cm and 0.1 kg, using a Health O Meter mechanical beam scale and stadiometer.	Participant’s weight will be divided by their height.
WC	Iliac crest	Health-risk indicator for cardiometabolic disease	WC will be measured twice at the top of the iliac crest, to the nearest 0.5 cm.	The two measures will be averaged.
4. Cardiovascular
BP	Brachial artery	Pressure of blood in the arteries	Resting systolic and diastolic blood pressure will be measured using a Life Source automated sphygmomanometer. Participants will be seated and resting quietly for 3 measurements.	The first reading will be discarded. The second and third readings will be averaged.
HR	Brachial Pulse	Estimate of cardiovascular fitness and heart function	Resting heart rate will be measured using a Life Source automated sphygmomanometer. Participants will be seated and resting quietly for 3 measurements.	The first reading will be discarded. The second and third readings will be averaged.
Uric Acid	Saliva	Associated with cardiovascular responses to stress	Passive drool	Lab analysis
Tobacco Use
Cotinine	Saliva	Biomarker for exposure to tobacco smoke	Passive drool	Lab analysis

CRP C-reactive protein, IL-1 Beta Interleukin-1 Beta, IL-6 Interleukin-6, IL-8 Interleukin-8, TNF α Tumor necrosis factor alpha, DHEA-S Dehydroepiandrosterone, BMI Body Mass index, WC Waist Circumference, BP Blood Pressure, HR Heart Rate. ^aThree samples will be collected in office during a 90-min participant appointment. Using a saliva collection aid, each participant will be given a 2-min time window to fill as much of one 2 ml cryovial as possible. If the participant fills the cryovial in less than 2 min, the time to completion will be noted on the vial. The first sample will be discarded and the other two will be sent to Salimetrics for analysis. ^bFor DHEA-S, the two samples will be pooled for analysis. The second saliva sample will be used for the analysis of all other biomarkers. The weight of the sample will be used to adjust for flow rate

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ISSN: 1471-2458

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