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Table 2 Univariable and multivariable Cox regression analysis for severe liver disease without/with multiple imputation

From: Is physician assessment of alcohol consumption useful in predicting risk of severe liver disease among people with HIV and HIV/HCV co-infection?

  Unadjusted
RH[95%CI]
p-value global
p-value
Model 1
RH[95%CI]
p-value global
p-value
Model 2
RH[95%CI]
p-value global
p-value
Model 3
RH[95%CI]
p-value global p-value Model 4
RH[95%CI]
p-value global
p-value
Alcohol consumption
 Abstainer 1.09 (0.87, 1.38) 0.446 <.001 1.08 (0.85, 1.37) 0.506 <.001 1.06 (0.84, 1.34) 0.640 0.007 1.10 (0.87, 1.40) 0.413 0.009 1.09 (0.86, 1.38) 0.498 0.446
 Moderate 1.00    1.00    1.00    1.00    1.00   
 Hazardous 1.61 (1.16, 2.26) 0.005   1.45 (1.04, 2.04) 0.028   1.45 (1.03, 2.03) 0.031   1.30 (0.95, 1.86) 0.129   1.32 (0.94, 1.85) 0.107  
 Unknown 1.67 (1.34, 2.09) <.001   1.56 (1.24, 1.95) <.001   1.37 (1.09, 1.72) 0.007   1.43 (1.13, 1.80) 0.003   1.12 (0..86, 1.46) 0.408  
Gender
 Male vs Female 1.17 (0.96, 1.43) 0.117 0.117 1.12 (0.91, 1.38) 0.286 0.286 1.13 (0.92, 1.39) 0.259 0.259 1.15 (0.92, 1.43) 0.213 0.213 1.15 (0.92, 1.43) 0.217 0.217
Age, years
 per 10 years older 1.60 (1.50, 1.71) <.001 <.001 1.56 (1.45, 1.67) <.001 <.001 1.48 (1.37, 1.59) <.001 <.001 1.47 (1.36, 1.59) <.001 <.001 1.46 (1.34, 1.58) <.001 <.001
Nationality
 Italian vs Non-Italian 1.75 (1.36, 2.25) <.001 <.001 1.26 (0.97, 1.65) 0.081 0.081 1.20 (0.92, 1.56) 0.184 0.184 0.97 (0.74, 1.27) 0.829 0.829 0.98 (0.74, 1.28) 0.877 0.877
Geographical Region
 North 1.00   0.096 1.00   0.341 1.00   0.242 1.00   0.391 1.00   0.353
 Center 0.83 (0.69, 0.98) 0.031   0.90 (0.75, 1.07) 0.226   0.88 (0.74, 1.05) 0.157   0.94 (0.79, 1.13) 0.553   0.95 (0.79, 1.14) 0.596  
 South 0.95 (0.72, 1.27) 0.739   1.08 (0.81, 1.44) 0.601   1.09 (0.81, 1.46) 0.584   1.16 (0.87, 1.58) 0.291   1.19 (0.89, 1.60) 0.240  
Calendar year enrolled
 2002–2006 1.00   <.001 1.00   <.001 1.00   <.001 1.00   <.001 1.00   <.001
 2007–2012 0.57 (0.45, 0.71) <.001   0.52 (0.41, 0.66) <.001   0.51 (0.40, 0.65) <.001   0.63 (0.49, 0.79) <.001   0.59 (0.46, 0.75) <.001  
 2012–2016 1.08 (0.86, 1.35) 0.511   0.88 (0.70, 1.11) 0.269   0.67 (0.53, 0.86) 0.001   0.69 (0.54, 0.89) 0.005   0.64 (0.49, 0.82) <.001  
AIDS Diagnosis
 Yes vs, No 1.64 (1.30, 2.07) <.001 <.001    1.34 (1.05, 1.73) 0.021 0.021 1.40 (1.09, 1.79) 0.008 0.008 1.40 (1.09, 1.80) 0.008 0.008
CD4 count
 ≤ 300 1.00   <.001    1.00   <.001 1.00   <.001 1.00   <.001
 301–500 0.69 (0.54, 0.90) 0.005     0.86 (0.65, 1.13) 0.280   0.91 (0.68, 1.19) 0.487   0.91 (0.69, 1.19) 0.491  
 > 500 0.96 (0.77, 1.20) 0.724     1.22 (0.95, 1.56) 0.113   1.39 (1.07, 1.78) 0.010   1.39 (1.08, 1.80) 0.008  
 Unknown 3.36 (2.72, 4.16) <.001     4.93 (3.60, 6.75) <.001   2.62 (1.86, 3.70) <.001   2.43 (1.72, 3.44) <.001  
Viral load, copies/mL
 ≤5000 1.00   <.001    1.00   <.001 1.00   0.012 1.00   0.010
 5000–10,000 0.64 (0.44, 0.93) 0.018     1.09 (0.73, 1.62) 0.670   1.53 (1.02, 2.30) 0.041   1.55 (1.03, 2.33) 0.034  
 10,000–100,000 0.63 (0.50, 0.79) <.001     1.12 (0.86, 1.45) 0.410   1.57 (1.19, 2.07) 0.001   1.59 (1.21, 2.10) 0.001  
 > 100,000 0.71 (0.56, 0.90) 0.005     1.08 (0.82, 1.43) 0.566   1.63 (1.21, 2.19) 0.001   1.64 (1.22, 2.22) 0.001  
 Unknown 1.43 (1.12, 1.83) 0.005     0.57 (0.44, 0.76) <.001   1.05 (0.79, 1.38) 0.752   1.06 (0.80, 1.40) 0.652  
HBV infection
 Yes vs, No 1.91 (1.33, 2.74) <.001 <.001    1.92 (1.34, 2.77) <.001 <.001 1.97 (1.37, 2.84) <.001 <.001 2.03 (1.41, 2.93) <.001 <.001
Mode of HIV Transmission
 PWID 1.00   <.001      1.00   <.001 1.00   <.001
 MSM 0.15 (0.13, 0.19) <.001       0.45 (0.34, 0.59) <.001   0.44 (0.33, 0.58) <.001  
 Heterosexual contacts 0.18 (0.15, 0.22) <.001       0.44 (0.33, 0.58) <.001   0.43 (0.32, 0.57) <.001  
 Other 0.32 (0.24, 0.43) <.001       0.64 (0.47, 0.89) 0.008   0.62 (0.45, 0.86) 0.004  
HCV infection
 No 1.00   <.001      1.00   <.001 1.00   <.001
 Yes 7.10 (5.89, 8.55) <.001       2.91 (2.22, 3.82) <.001   2.94 (2.24, 3.86) <.001  
 Unknown 1.67 (1.37, 2.05) <.001       1.36 (1.10, 1.69) 0.005   1.34 (1.08, 1.67) 0.007  
Smoking status
 No 1.00   <.001        1.00   0.001
 Yes 1.39 (1.13, 1.70) 0.001         0.91 (0.73, 1.13) 0.405  
 Unknown 2.30 (1.89, 2.80) <.001         1.46 (1.12, 1.91) 0.006  
With Multiple Imputation
 Alcohol consumption
  Abstainer 1.15 (0.90, 1.47) 0.261   1.13 (0.88, 1.45) 0.339   1.11 (0.87, 1.42) 0.394   1.13 (0.89, 1.44) 0.315   1.13 (0.88, 1.45) 0.353 0.724
  Moderate 1.00    1.00    1.00    1.00    1.00   
  Hazardous 1.70 (1.24, 2.34) 0.002   1.48 (1.07, 2.05) 0.020   1.43 (1.03, 1.99) 0.037   1.29 (0.93, 1.78) 0.120   1.30 (0.94, 1.81) 0.114  
  1. 1. Age, gender, ethnicity, geographical region, calendar year enrolled; 2. Model 1 + HIV-related factors + HBV; 3. Model 2 + Mode of HIV transmission and HCV infection; 4. Model 3 + Smoking status