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Table 2 Univariable and multivariable Cox regression analysis for severe liver disease without/with multiple imputation

From: Is physician assessment of alcohol consumption useful in predicting risk of severe liver disease among people with HIV and HIV/HCV co-infection?

 

Unadjusted

RH[95%CI]

p-value

global

p-value

Model 1

RH[95%CI]

p-value

global

p-value

Model 2

RH[95%CI]

p-value

global

p-value

Model 3

RH[95%CI]

p-value

global p-value

Model 4

RH[95%CI]

p-value

global

p-value

Alcohol consumption

 Abstainer

1.09 (0.87, 1.38)

0.446

<.001

1.08 (0.85, 1.37)

0.506

<.001

1.06 (0.84, 1.34)

0.640

0.007

1.10 (0.87, 1.40)

0.413

0.009

1.09 (0.86, 1.38)

0.498

0.446

 Moderate

1.00

  

1.00

  

1.00

  

1.00

  

1.00

  

 Hazardous

1.61 (1.16, 2.26)

0.005

 

1.45 (1.04, 2.04)

0.028

 

1.45 (1.03, 2.03)

0.031

 

1.30 (0.95, 1.86)

0.129

 

1.32 (0.94, 1.85)

0.107

 

 Unknown

1.67 (1.34, 2.09)

<.001

 

1.56 (1.24, 1.95)

<.001

 

1.37 (1.09, 1.72)

0.007

 

1.43 (1.13, 1.80)

0.003

 

1.12 (0..86, 1.46)

0.408

 

Gender

 Male vs Female

1.17 (0.96, 1.43)

0.117

0.117

1.12 (0.91, 1.38)

0.286

0.286

1.13 (0.92, 1.39)

0.259

0.259

1.15 (0.92, 1.43)

0.213

0.213

1.15 (0.92, 1.43)

0.217

0.217

Age, years

 per 10 years older

1.60 (1.50, 1.71)

<.001

<.001

1.56 (1.45, 1.67)

<.001

<.001

1.48 (1.37, 1.59)

<.001

<.001

1.47 (1.36, 1.59)

<.001

<.001

1.46 (1.34, 1.58)

<.001

<.001

Nationality

 Italian vs Non-Italian

1.75 (1.36, 2.25)

<.001

<.001

1.26 (0.97, 1.65)

0.081

0.081

1.20 (0.92, 1.56)

0.184

0.184

0.97 (0.74, 1.27)

0.829

0.829

0.98 (0.74, 1.28)

0.877

0.877

Geographical Region

 North

1.00

 

0.096

1.00

 

0.341

1.00

 

0.242

1.00

 

0.391

1.00

 

0.353

 Center

0.83 (0.69, 0.98)

0.031

 

0.90 (0.75, 1.07)

0.226

 

0.88 (0.74, 1.05)

0.157

 

0.94 (0.79, 1.13)

0.553

 

0.95 (0.79, 1.14)

0.596

 

 South

0.95 (0.72, 1.27)

0.739

 

1.08 (0.81, 1.44)

0.601

 

1.09 (0.81, 1.46)

0.584

 

1.16 (0.87, 1.58)

0.291

 

1.19 (0.89, 1.60)

0.240

 

Calendar year enrolled

 2002–2006

1.00

 

<.001

1.00

 

<.001

1.00

 

<.001

1.00

 

<.001

1.00

 

<.001

 2007–2012

0.57 (0.45, 0.71)

<.001

 

0.52 (0.41, 0.66)

<.001

 

0.51 (0.40, 0.65)

<.001

 

0.63 (0.49, 0.79)

<.001

 

0.59 (0.46, 0.75)

<.001

 

 2012–2016

1.08 (0.86, 1.35)

0.511

 

0.88 (0.70, 1.11)

0.269

 

0.67 (0.53, 0.86)

0.001

 

0.69 (0.54, 0.89)

0.005

 

0.64 (0.49, 0.82)

<.001

 

AIDS Diagnosis

 Yes vs, No

1.64 (1.30, 2.07)

<.001

<.001

  

1.34 (1.05, 1.73)

0.021

0.021

1.40 (1.09, 1.79)

0.008

0.008

1.40 (1.09, 1.80)

0.008

0.008

CD4 count

 ≤ 300

1.00

 

<.001

  

1.00

 

<.001

1.00

 

<.001

1.00

 

<.001

 301–500

0.69 (0.54, 0.90)

0.005

 

  

0.86 (0.65, 1.13)

0.280

 

0.91 (0.68, 1.19)

0.487

 

0.91 (0.69, 1.19)

0.491

 

 > 500

0.96 (0.77, 1.20)

0.724

 

  

1.22 (0.95, 1.56)

0.113

 

1.39 (1.07, 1.78)

0.010

 

1.39 (1.08, 1.80)

0.008

 

 Unknown

3.36 (2.72, 4.16)

<.001

 

  

4.93 (3.60, 6.75)

<.001

 

2.62 (1.86, 3.70)

<.001

 

2.43 (1.72, 3.44)

<.001

 

Viral load, copies/mL

 ≤5000

1.00

 

<.001

  

1.00

 

<.001

1.00

 

0.012

1.00

 

0.010

 5000–10,000

0.64 (0.44, 0.93)

0.018

 

  

1.09 (0.73, 1.62)

0.670

 

1.53 (1.02, 2.30)

0.041

 

1.55 (1.03, 2.33)

0.034

 

 10,000–100,000

0.63 (0.50, 0.79)

<.001

 

  

1.12 (0.86, 1.45)

0.410

 

1.57 (1.19, 2.07)

0.001

 

1.59 (1.21, 2.10)

0.001

 

 > 100,000

0.71 (0.56, 0.90)

0.005

 

  

1.08 (0.82, 1.43)

0.566

 

1.63 (1.21, 2.19)

0.001

 

1.64 (1.22, 2.22)

0.001

 

 Unknown

1.43 (1.12, 1.83)

0.005

 

  

0.57 (0.44, 0.76)

<.001

 

1.05 (0.79, 1.38)

0.752

 

1.06 (0.80, 1.40)

0.652

 

HBV infection

 Yes vs, No

1.91 (1.33, 2.74)

<.001

<.001

  

1.92 (1.34, 2.77)

<.001

<.001

1.97 (1.37, 2.84)

<.001

<.001

2.03 (1.41, 2.93)

<.001

<.001

Mode of HIV Transmission

 PWID

1.00

 

<.001

  

  

1.00

 

<.001

1.00

 

<.001

 MSM

0.15 (0.13, 0.19)

<.001

 

  

  

0.45 (0.34, 0.59)

<.001

 

0.44 (0.33, 0.58)

<.001

 

 Heterosexual contacts

0.18 (0.15, 0.22)

<.001

 

  

  

0.44 (0.33, 0.58)

<.001

 

0.43 (0.32, 0.57)

<.001

 

 Other

0.32 (0.24, 0.43)

<.001

 

  

  

0.64 (0.47, 0.89)

0.008

 

0.62 (0.45, 0.86)

0.004

 

HCV infection

 No

1.00

 

<.001

  

  

1.00

 

<.001

1.00

 

<.001

 Yes

7.10 (5.89, 8.55)

<.001

 

  

  

2.91 (2.22, 3.82)

<.001

 

2.94 (2.24, 3.86)

<.001

 

 Unknown

1.67 (1.37, 2.05)

<.001

 

  

  

1.36 (1.10, 1.69)

0.005

 

1.34 (1.08, 1.67)

0.007

 

Smoking status

 No

1.00

 

<.001

  

  

  

1.00

 

0.001

 Yes

1.39 (1.13, 1.70)

0.001

 

  

  

  

0.91 (0.73, 1.13)

0.405

 

 Unknown

2.30 (1.89, 2.80)

<.001

 

  

  

  

1.46 (1.12, 1.91)

0.006

 

With Multiple Imputation

 Alcohol consumption

  Abstainer

1.15 (0.90, 1.47)

0.261

 

1.13 (0.88, 1.45)

0.339

 

1.11 (0.87, 1.42)

0.394

 

1.13 (0.89, 1.44)

0.315

 

1.13 (0.88, 1.45)

0.353

0.724

  Moderate

1.00

  

1.00

  

1.00

  

1.00

  

1.00

  

  Hazardous

1.70 (1.24, 2.34)

0.002

 

1.48 (1.07, 2.05)

0.020

 

1.43 (1.03, 1.99)

0.037

 

1.29 (0.93, 1.78)

0.120

 

1.30 (0.94, 1.81)

0.114

 
  1. 1. Age, gender, ethnicity, geographical region, calendar year enrolled; 2. Model 1 + HIV-related factors + HBV; 3. Model 2 + Mode of HIV transmission and HCV infection; 4. Model 3 + Smoking status