Unadjusted RH[95%CI] | p-value | global p-value | Model 1 RH[95%CI] | p-value | global p-value | Model 2 RH[95%CI] | p-value | global p-value | Model 3 RH[95%CI] | p-value | global p-value | Model 4 RH[95%CI] | p-value | global p-value | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alcohol consumption | |||||||||||||||
Abstainer | 1.09 (0.87, 1.38) | 0.446 | <.001 | 1.08 (0.85, 1.37) | 0.506 | <.001 | 1.06 (0.84, 1.34) | 0.640 | 0.007 | 1.10 (0.87, 1.40) | 0.413 | 0.009 | 1.09 (0.86, 1.38) | 0.498 | 0.446 |
Moderate | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||||
Hazardous | 1.61 (1.16, 2.26) | 0.005 | 1.45 (1.04, 2.04) | 0.028 | 1.45 (1.03, 2.03) | 0.031 | 1.30 (0.95, 1.86) | 0.129 | 1.32 (0.94, 1.85) | 0.107 | |||||
Unknown | 1.67 (1.34, 2.09) | <.001 | 1.56 (1.24, 1.95) | <.001 | 1.37 (1.09, 1.72) | 0.007 | 1.43 (1.13, 1.80) | 0.003 | 1.12 (0..86, 1.46) | 0.408 | |||||
Gender | |||||||||||||||
Male vs Female | 1.17 (0.96, 1.43) | 0.117 | 0.117 | 1.12 (0.91, 1.38) | 0.286 | 0.286 | 1.13 (0.92, 1.39) | 0.259 | 0.259 | 1.15 (0.92, 1.43) | 0.213 | 0.213 | 1.15 (0.92, 1.43) | 0.217 | 0.217 |
Age, years | |||||||||||||||
per 10 years older | 1.60 (1.50, 1.71) | <.001 | <.001 | 1.56 (1.45, 1.67) | <.001 | <.001 | 1.48 (1.37, 1.59) | <.001 | <.001 | 1.47 (1.36, 1.59) | <.001 | <.001 | 1.46 (1.34, 1.58) | <.001 | <.001 |
Nationality | |||||||||||||||
Italian vs Non-Italian | 1.75 (1.36, 2.25) | <.001 | <.001 | 1.26 (0.97, 1.65) | 0.081 | 0.081 | 1.20 (0.92, 1.56) | 0.184 | 0.184 | 0.97 (0.74, 1.27) | 0.829 | 0.829 | 0.98 (0.74, 1.28) | 0.877 | 0.877 |
Geographical Region | |||||||||||||||
North | 1.00 | 0.096 | 1.00 | 0.341 | 1.00 | 0.242 | 1.00 | 0.391 | 1.00 | 0.353 | |||||
Center | 0.83 (0.69, 0.98) | 0.031 | 0.90 (0.75, 1.07) | 0.226 | 0.88 (0.74, 1.05) | 0.157 | 0.94 (0.79, 1.13) | 0.553 | 0.95 (0.79, 1.14) | 0.596 | |||||
South | 0.95 (0.72, 1.27) | 0.739 | 1.08 (0.81, 1.44) | 0.601 | 1.09 (0.81, 1.46) | 0.584 | 1.16 (0.87, 1.58) | 0.291 | 1.19 (0.89, 1.60) | 0.240 | |||||
Calendar year enrolled | |||||||||||||||
2002–2006 | 1.00 | <.001 | 1.00 | <.001 | 1.00 | <.001 | 1.00 | <.001 | 1.00 | <.001 | |||||
2007–2012 | 0.57 (0.45, 0.71) | <.001 | 0.52 (0.41, 0.66) | <.001 | 0.51 (0.40, 0.65) | <.001 | 0.63 (0.49, 0.79) | <.001 | 0.59 (0.46, 0.75) | <.001 | |||||
2012–2016 | 1.08 (0.86, 1.35) | 0.511 | 0.88 (0.70, 1.11) | 0.269 | 0.67 (0.53, 0.86) | 0.001 | 0.69 (0.54, 0.89) | 0.005 | 0.64 (0.49, 0.82) | <.001 | |||||
AIDS Diagnosis | |||||||||||||||
Yes vs, No | 1.64 (1.30, 2.07) | <.001 | <.001 | – | 1.34 (1.05, 1.73) | 0.021 | 0.021 | 1.40 (1.09, 1.79) | 0.008 | 0.008 | 1.40 (1.09, 1.80) | 0.008 | 0.008 | ||
CD4 count | |||||||||||||||
≤ 300 | 1.00 | <.001 | – | 1.00 | <.001 | 1.00 | <.001 | 1.00 | <.001 | ||||||
301–500 | 0.69 (0.54, 0.90) | 0.005 | – | 0.86 (0.65, 1.13) | 0.280 | 0.91 (0.68, 1.19) | 0.487 | 0.91 (0.69, 1.19) | 0.491 | ||||||
> 500 | 0.96 (0.77, 1.20) | 0.724 | – | 1.22 (0.95, 1.56) | 0.113 | 1.39 (1.07, 1.78) | 0.010 | 1.39 (1.08, 1.80) | 0.008 | ||||||
Unknown | 3.36 (2.72, 4.16) | <.001 | – | 4.93 (3.60, 6.75) | <.001 | 2.62 (1.86, 3.70) | <.001 | 2.43 (1.72, 3.44) | <.001 | ||||||
Viral load, copies/mL | |||||||||||||||
≤5000 | 1.00 | <.001 | – | 1.00 | <.001 | 1.00 | 0.012 | 1.00 | 0.010 | ||||||
5000–10,000 | 0.64 (0.44, 0.93) | 0.018 | – | 1.09 (0.73, 1.62) | 0.670 | 1.53 (1.02, 2.30) | 0.041 | 1.55 (1.03, 2.33) | 0.034 | ||||||
10,000–100,000 | 0.63 (0.50, 0.79) | <.001 | – | 1.12 (0.86, 1.45) | 0.410 | 1.57 (1.19, 2.07) | 0.001 | 1.59 (1.21, 2.10) | 0.001 | ||||||
> 100,000 | 0.71 (0.56, 0.90) | 0.005 | – | 1.08 (0.82, 1.43) | 0.566 | 1.63 (1.21, 2.19) | 0.001 | 1.64 (1.22, 2.22) | 0.001 | ||||||
Unknown | 1.43 (1.12, 1.83) | 0.005 | – | 0.57 (0.44, 0.76) | <.001 | 1.05 (0.79, 1.38) | 0.752 | 1.06 (0.80, 1.40) | 0.652 | ||||||
HBV infection | |||||||||||||||
Yes vs, No | 1.91 (1.33, 2.74) | <.001 | <.001 | – | 1.92 (1.34, 2.77) | <.001 | <.001 | 1.97 (1.37, 2.84) | <.001 | <.001 | 2.03 (1.41, 2.93) | <.001 | <.001 | ||
Mode of HIV Transmission | |||||||||||||||
PWID | 1.00 | <.001 | – | – | 1.00 | <.001 | 1.00 | <.001 | |||||||
MSM | 0.15 (0.13, 0.19) | <.001 | – | – | 0.45 (0.34, 0.59) | <.001 | 0.44 (0.33, 0.58) | <.001 | |||||||
Heterosexual contacts | 0.18 (0.15, 0.22) | <.001 | – | – | 0.44 (0.33, 0.58) | <.001 | 0.43 (0.32, 0.57) | <.001 | |||||||
Other | 0.32 (0.24, 0.43) | <.001 | – | – | 0.64 (0.47, 0.89) | 0.008 | 0.62 (0.45, 0.86) | 0.004 | |||||||
HCV infection | |||||||||||||||
No | 1.00 | <.001 | – | – | 1.00 | <.001 | 1.00 | <.001 | |||||||
Yes | 7.10 (5.89, 8.55) | <.001 | – | – | 2.91 (2.22, 3.82) | <.001 | 2.94 (2.24, 3.86) | <.001 | |||||||
Unknown | 1.67 (1.37, 2.05) | <.001 | – | – | 1.36 (1.10, 1.69) | 0.005 | 1.34 (1.08, 1.67) | 0.007 | |||||||
Smoking status | |||||||||||||||
No | 1.00 | <.001 | – | – | – | 1.00 | 0.001 | ||||||||
Yes | 1.39 (1.13, 1.70) | 0.001 | – | – | – | 0.91 (0.73, 1.13) | 0.405 | ||||||||
Unknown | 2.30 (1.89, 2.80) | <.001 | – | – | – | 1.46 (1.12, 1.91) | 0.006 | ||||||||
With Multiple Imputation | |||||||||||||||
Alcohol consumption | |||||||||||||||
Abstainer | 1.15 (0.90, 1.47) | 0.261 | 1.13 (0.88, 1.45) | 0.339 | 1.11 (0.87, 1.42) | 0.394 | 1.13 (0.89, 1.44) | 0.315 | 1.13 (0.88, 1.45) | 0.353 | 0.724 | ||||
Moderate | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||||
Hazardous | 1.70 (1.24, 2.34) | 0.002 | 1.48 (1.07, 2.05) | 0.020 | 1.43 (1.03, 1.99) | 0.037 | 1.29 (0.93, 1.78) | 0.120 | 1.30 (0.94, 1.81) | 0.114 |