Table 5 Factors Associated with Loss to Follow-up Among Children on ART at LCH (2003–2015)
Predictor | N | LTFU | Unadjusted HR (95% C1) | p-value | Adjusted HR (95% CI) | p-value |
|---|---|---|---|---|---|---|
Gender (N%) | ||||||
Male | 519 | 92 | 1.2 (0.9–1.7) | 0.1929 | ||
Female | 520 | 75 | Ref | |||
Age Continuous | 0.94 (0.91–0.98) | 0.001 | ||||
Categorical Age | ||||||
< 1 year | 179 | 45 | 2.7 (1.8–3.9) | <.0001 | ||
1–5 years | 387 | 59 | 1. 3 (0.9–1.8) | 0.1717 | ||
> 5 years | 473 | 59 | Ref | |||
Year of ART Initiation | ||||||
2003–2005 | 71 | 10 | Ref | Ref | ||
2006–2009 | 512 | 81 | 2.2 (1.0–4.5) | 0.0293 | 2.3 (1.1–4.9) | 0.0316 |
2010–2012 | 305 | 53 | 3.6 (1.7–7.7) | 0.0009 | 3.5 (1.6–7.9) | 0.002 |
2013–2016 | 151 | 20 | 5. 1 (2.2–11.9) | 0.0002 | 5.6 (2.2–14.1) | 0.0002 |
Low-weight < −3SD | ||||||
Yes | 182 | 34 | 1.6 (1.1–2.4) | 0.0117 | 1.1 (0.7–1.6) | 0.7145 |
No | 857 | 133 | Ref | Ref | ||
Baseline CD4% | ||||||
< 15% | 307 | 58 | 1.9 (1.1–3.4) | 0.03 | ||
15–25% | 261 | 36 | 1.3 (0.7–2.4) | 0.3675 | ||
> =25% | 112 | 14 | Ref | |||
missing | 359 | 59 | ||||
Baseline Hemoglobin (Continuous) | 1039 | 0.87 (0.7–0.9) | 0.0036 | 0.9 (0.8–1.0) | 0.0694 | |
Baseline Hemoglobin (Categorical) | ||||||
< =8 | 335 | 67 | 1.4 (1.03–1.9) | 0.0477 | 1.2 (0.9–1.7) | 0.1958 |
> 8 | 704 | 100 | Ref | |||
WHO Stage at Baseline | ||||||
Stage 1 and 2 | 377 | 57 | Ref | |||
Stage 3 | 471 | 70 | 0.9 (0.6–1.3) | 0.5036 | ||
Stage 4 | 177 | 36 | 1.6 (1.0–2.3) | 0.0356 | ||
TB at Baseline | ||||||
Yes | 318 | 46 | Ref | |||
No | 721 | 118 | 0.8 (0.5–1.0) | 0.1279 | ||
Access to Phone | ||||||
Yes | 705 | 85 | Ref | Ref | ||
No | 340 | 82 | 2.1 (1.6–2.9) | <.0001 | 1.8 (1.3–2.5) | 0.0002 |
Regimen at Baseline | ||||||
1NNRTI + 2NRTi’s | 907 | 124 | Ref | Ref | ||
LPV/R Based Regimen | 54 | 16 | 2.9 (1.7–4.9) | <.0001 | 1.9 (1.0–3.3) | 0.0374 |
3NRTIs | 78 | 25 | 3.4 (2.3–5.4) | <.0001 | 2.6 (1.6–4.2) | 0.0001 |
Mother Took ART for PMTCT | ||||||
Yes | 162 | 31 | Ref | |||
No | 877 | 136 | 0.6 (0.4–0.9) | 0.03 | 1.0 (0.6–1.5) | |
HIV Status Disclosed at Baselinea | ||||||
Yes | 191 | 24 | Ref | Ref | ||
No | 854 | 143 | 1.9 (1.2–2.9) | 0.004 | 1.4 (0.9–2.4) | 0.1704 |