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Table 2 Patients reporting ≥1 antibiotic by class and mean duration of antibiotic use, among antibiotic users by patient status and country

From: The use of antibiotics in the treatment of pediatric varicella patients: real-world evidence from the multi-country MARVEL study in Latin America & Europe

 

Outpatient

Inpatient

Argentina N = 75

Hungary N = 75

Mexico N = 75

Peru N = 101

Poland N = 75

Total N = 401

Argentina N = 75

Hungary N = 81

Mexico N = 77

Peru N = 78

Poland N = 75

Total N = 386

Patients prescribed ≥1 antibiotic, n (%)

17 (22.7)

2 (2.7)

6 (8.0)

17 (16.8)

9 (12.0)

51 (12.7)

54 (72.0)

45 (55.6)

57 (74.0)

67 (85.9)

43 (57.3)

266 (68.9)

Mean (95% CI), number of antibiotics prescribed per patient a

1.8 (1.2, 2.5)

1.0 (0.2, 3.1)

1.5 (0.7, 2.7)

1.1 (0.7, 1.7)

1.1 (0.6, 1.9)

1.4 (1.1, 1.7)

2.1 (1.7, 2.5)

1.7 (1.4, 2.1)

2.5 (2.1, 2.9)

2.2 (1.8, 2.5)

1.5 (1.2, 1.9)

2.0 (1.9, 2.2)

Mean (95% CI) duration of antibiotics prescribed per patient, days a

9.5 (8.1, 11.1)

7.0 (4.1, 11.8)

8.2 (6.2, 10.8))

6.5 (5.3, 7.8)

8.7 (6.9, 10.7)

7.9 (6.9, 10.5)

10.6 (9.7, 11.5)

7.2 (6.4, 8.0)

16.1 (15.0, 17.1)

14.6 (13.7, 15.5)

8.6 (7.7, 9.5)

10.9 (10.5, 11.3)

Patients prescribed ≥1 antibiotic, by class, n (%) a,b, c

β-lactam agent

15 (88.2)

2 (100.0)

4 (66.7)

12 (70.6)

8 (88.9)

41 (80.4)

32 (59.3)

43 (95.6)

51 (89.5)

66 (98.5)

37 (86.0)

229 (86.1)

Lincosamide

7 (41.2)

3 (50.0)

10 (19.6)

39 (72.2)

8 (17.8)

35 (61.4)

31 (46.3)

4 (9.3)

117 (44.0)

Aminoglycide

1 (5.9)

1 (2.0)

5 (9.3)

6 (13.3)

5 (8.8)

2 (3.0)

3 (7.0)

21 (7.9)

Glycopeptide

3 (5.6)

9 (15.8)

5 (7.5)

1 (2.3)

18 (6.8)

Other

7 (41.2)

1 (16.7)

5 (29.4)

1 (11.1)

14 (27.5)

12 (22.2)

2 (3.5)

1 (1.5)

15 (5.6)

Macrolide

1 (5.9)

1 (11.1)

2 (3.9)

2 (3.5)

5 (11.6)

7 (2.6)

Fluoroquinolone

1 (2.2)

2 (3.5)

1 (2.3)

4 (1.5)

Mean (95% CI) duration of use, by class, days a

β-lactam agent

5.8 (4.7, 7.1)

7.0 (4.1, 11.8)

4.3 (2.6, 6.8)

6.2 (4.9, 7.7)

7.1 (5.5, 9.2)

6.0 (5.1, 7.0)

8.4 (7.5, 9.5)

6.2 (5.5,7.0)

9.2 (8.4, 10.0)

10.1 (9.3, 10.9)

7.4 (6.5,8.3)

8.1 (7.8, 8.5)

Lincosamide

4.9 (3.5, 6.8)

6.0 (3.8, 9.5)

 

5.4 (4.1, 7.2)

5.4 (4.7, 6.1)

4.0 (2.8, 5.7)

8.1 (7.2, 9.1)

6.8 (5.9, 7.8)

8.5 (6.1, 11.9)

6.3 (5.7, 7.0)

Aminoglycide

1.0 (0.1, 7.1)

1.0 (0.1, 7.1)

4.2 (2.7, 6.4)

3.5 (2.3, 5.4)

5.4 (3.7, 7.8)

8.5 (5.3, 13.7)

5.7 (3.5, 9.1)

5.2 (4.3, 6.3)

Glycopeptide

6.0 (3.8, 9.5)

9.0 (7.2, 11.2)

14.8 (11.8, 18.6)

5.0 (NA)

8.0 (6.1, 10.3)

Other

8.7 (5.9, 12.7)

14.0 (8.3, 23.6)

5.6 (3.9, 8.1)

7.0 (3.3, 14.7)

8.3 (6.4, 10.8)

4.1 (3.1, 54)

6.3 (4.0, 9.9)

10.0(NA)

6.4 (4.9, 8.4)

Macrolide

7.0 (3.3, 14.7)

14.0 (8.3, 23.7)

9.9 (6.3, 15.6)

4.5 (2.3, 8.6)

6.6 (4.7, 9.3)

5.4 (3.8, 7.9)

Fluoroquinolone

3.0 (1.0, 9.3)

9.0 (5.7, 14.3)

7.0 (3.3, 14.7)

5.7 (3.6, 9.2)

  1. CI Confidence Interval
  2. a Among population of antibiotic users
  3. b Reported for classes of antibiotics administered to > 1.0% of the total inpatient and/or outpatient population
  4. c Patients may have been prescribed ≥1 antibiotic