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Table 6 Severity of gastric pathology by Hp status, 308 CANHelp project participants with histopathology data, 2008–2013

From: Burden of disease from Helicobacter pylori infection in western Canadian Arctic communities

Pathology

Hp positive (n = 224)

Hp negative (n = 84)

 

n

%a

95% CI

n

%a

95% CI

χ2-p-valuee:

Normal histopathologyb

 No

223

99.6

99, 100

19

23

14, 32

0.000

 Yes

1

0.4

0, 2

65

77

68, 86

Active gastritisc

 None

7

3

1, 6

82

98

94, 100

0.000

 Mild

102

46

39, 52

2

2

0, 8

 Moderate

81

36

30, 42

0

0

0, 4

 Severe

32

14

10, 19

0

0

0, 4

Chronic gastritis

 None

2

1

0, 2

73

87

80, 94

0.000

 Mild

17

8

4, 11

10

12

5, 19

 Moderate

99

44

38, 51

1

1

0, 6

 Severe

106

47

41, 54

0

0

0, 4

Atrophy

 None

128

57

51, 64

84

100

96, 100

0.000

 Mild

68

30

24, 36

0

0

0, 4

 Moderate

23

10

6, 14

0

0

0, 4

 Severe

5

2

1, 5

0

0

0, 4

Intestinal metaplasia

 None

185

83

78, 88

80

95

91, 100

0.002

 Mild

23

10

6, 14

4

5

1, 12

 Moderate

13

6

3, 9

0

0

0, 4

 Severe

3

1

0, 4

0

0

0, 4

MALT hyperplasiad (n = 114; 96 HP+)

 None

3

3

1, 9

13

72

52, 93

0.000

 Mild

34

35

26, 45

5

28

10, 53

 Moderate

45

47

37, 57

0

0

0, 19

 Severe

14

15

8, 22

0

0

0, 19

Lymphoid aggregatesd (n = 194; 128 HP+)

 Present

74

58

49, 66

5

8

3, 17

0.000

Lymphoepithelial lesions

 Present

7

3

1, 6

0

0

0, 4

0.101

Dysplasia or Carcinoma

 Present

0

0

0, 2

0

0

0, 4

n/a

  1. Hp H. pylori, CI binomial Wald confidence interval (binomial exact CI for numerators < 10; one-sided binomial exact 97.5% CI for numerators of 0)
  2. aDistributions do not all sum 100% due to rounding
  3. bExcludes MALT hyperplasia or lymphoid aggregates; includes reactive gastropathy
  4. c2 H. pylori-positive participants lack classification for active gastritis
  5. dIn 2008, presence/absence of lymphoid aggregates was noted without grading MALT hyperplasia; after 2008, MALT hyperplasia was graded instead of noting presence/absence of lymphoid aggregates
  6. eFrom score test for trend of odds
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BMC Public Health

ISSN: 1471-2458

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