Table 3 Time scheme for study conduction

TIMEPOINT➔

t-1

t0

t1

t2

t3

t4^†

t5^†

t5^†

Timepoint description

Interviews

Occurs in 2 or 3 evaluation visits

–

Intervention Start

Evaluation visit (6th week)

Intervention end

Final evaluation visit 1

Final evaluation visit 2

 Eligibility screening

x

 Informed consent

x

 Allocation

x

 Combined exercise program

x

x

x

 Health education program

x

x

x

 Ambulatory blood pressure

x

x

 Office blood pressure

x

x

 Endothelial function^‡

x

x

x

 Cardiorespiratory fitness^§

x

x

x

 6-min walking test distance

x

x

 SPPB

x

x

 Quality of life questionnaires

x

x

 Autonomic function^‡

x

x

 Anthropometric measurements

x

x

 Medication adherence scale (MMAS-8 Questionnaires)

x

x

 Blood variables collection

x

x

 Self-reported physical activity

x

x

x

 Grip strength

x

x

x