Table 5 Parameter values (deterministic, in ranges) for modelling: Quality of life weights (health utilities), ∆ health utilities and ∆ QALYs

Stroke

0·31 to 0·94

Lovibond and colleagues [37]

 Coronary heart disease

0·55 to 0·79

Derived from Lovibond and colleagues [37] and Dyer and colleagues [64]; weighted average of health utility values for heart failure (0.645), angina (0.77) and MI (0.76); weighted with their proportions of CHD (as above)

 Hypertension (without cardiovascular event)

0·704 to 0·909

Lovibond and colleagues [37]; refers to general population health utilities from Health Survey England data

 Bowel cancer

0·697 (+/−10%)

Whyte and colleagues [65]

 Bowel cancer stages Duke’s A, B, C,D

0·74; 0·70; 0·5; 0·25 (+/− 10%)

Tappenden and colleagues [66]

 Breast cancer

0·627 to 0·767

Whyte and colleagues [65]

 HIP fracture, 1st year

0·64 to 0·77

 Without HIP fracture, 50 to 60 years

0·6 to 0·85

As above

 Without HIP fracture, 60 years +

0·55 to 0·82

As above

 Glaucoma, mild

0·72 to 0·88

Burr and colleagues [46]

 Glaucoma, moderate

0·67 to 0·82

As above

 Glaucoma, severe

0·64 to 0·78

As above

 Health utility gain (∆) from  removed ear wax

0·0054 to 0·0066

Morris and colleagues [62]

 Health utility gain (∆) from hearing aid

0·035 to 0·105

NICE [41]

 QALYs (∆), controlled vs. uncontrolled diabetes in non-overweight patients

−0·07 to 0·22

Clarke and colleagues [38]; refers to present value of QALYs gained for intensive vs. standard management

 QALYs (∆), controlled vs. uncontrolled diabetes in overweight patients

−0·04 to 0·48

As above

 QALY gain linked to cataract surgery

0·084 to 0·963

Frampton and colleagues [47]