Skip to main content

Table 3 Cox multivariate-adjusted HRs for all-cause mortality in the EPIC-Norfolk 1993-2015 per 70cL/s increase in FEV1 in subgroups adjusted by age and other covariates

From: FEV1 and total Cardiovascular mortality and morbidity over an 18 years follow-up Population-Based Prospective EPIC-NORFOLK Study

  Number/ Total HR (95%CI) per 70 cL/s increase in FEV1 a P HR (95%CI) per 70 cL/s increase in FEV1 b P
All 4734/19139 0.71(0.68, 0.73) <0.001 0.74(0.71, 0.77) <0.001
Gender
 Men 2572/8719 0.72(0.69, 0.76) <0.001 0.77(0.73, 0.81) <0.001
 Women 2162/8258 0.67(0.62, 0.72) <0.001 0.68(0.63, 0.74) <0.001
Age
 <65 1661/13631 0.74(0.70, 0.78) <0.001 0.79(0.74, 0.84) <0.001
 ≥65 3073/5508 0.67(0.65, 0.71) <0.001 0.70(0.67, 0.74) <0.001
Excluding early deaths < 5 years 4196/18601 0.72(0.69, 0.75) <0.001 0.76(0.72, 0.79) <0.001
Smoking status
 -Current smokers 670/ 2214 0.72(0.65, 0.80) <0.001 0.71(0.63, 0.79) <0.001
 -Ex-smokers 2344/7955 0.71(0.67, 0.75) <0.001 0.72(0.68, 0.76) <0.001
 -Never smokers 1720/8970 0.81(0.75, 0.87) <0.001 0.82(0.76, 0.89) <0.001
By BMI
 <27 kg/m2 2759/12146 0.69(0.66, 0.73) <0.001 0.73(0.69, 0.77) <0.001
 ≥27 kg/m2 1975/6993 0.72(0.69, 0.78) <0.001 0.75(0.71, 0.81) <0.001
By physical activity      
 - Inactive 1977/5467 0.65(0.62, 0.69) <0.001 0.68(0.64, 0.72) <0.001
 - Active 2757/13672 0.76(0.72, 0.80) <0.001 0.79(0.75, 0.84) <0.001
Excluding asthma or bronchitis 4772/17837 0.72(0.69, 0.75) <0.001 0.76(0.73, 0.79) <0.001
Social class
 -Nonmanual social class 2737/11509 0.73(0.69, 0.77) <0.001 0.75(0.71, 0.80) <0.001
 -Manual social class 1997/7630 0.69(0.65, 0.73) <0.001 0.72(0.68, 0.77) <0.001
Plasma Vitamin C
 -Less than median 2646/9206 0.71(0.67, 0.75) <0.001 0.73(0.69, 0.77) <0.001
 -more than median 2088/9933 0.74(0.69, 0.78) <0.001 0.75(0.71, 0.80) <0.001
  1. Foot note: a Model 1: adjusting for age
  2. bModel 2: adjustment for BMI, cigarette-smoking habit, alcohol intake, physical activity, height, education level, plasma vitamin C, social class, self-reported diabetes, respiratory disease, systolic blood pressure and plasma total cholesterol