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Table 4 Risk factors for severe disease among hospitalized patients enrolled in VICo respiratory syndrome surveillance, 2008–2012 (N = 446)

From: Hospitalization and death among patients with influenza, Guatemala, 2008–2012

Characteristics

Severe Diseasea(n = 88)

Less Severe (n = 358)

Bivariate OR (95% CI)

MultivariatebOR (95%)

Age Group

 0–2

43 (21.0)

162 (79.0)

1

 

 2–5

16 (28.6)

40 (71.4)

1.5 (0.8–2.9)

 

 5–15

10 (29.4)

24 (70.6)

1.6 (0.7–3.5)

 

 15–50

8 (11.3)

63 (88.7)

0.5 (0.2–1.1)

 

 50–65

6 (16.7)

30 (83.3)

0.8 (0.3–1.9)

 

 65+

5 (11.4)

39 (88.6)

0.5 (0.2–1.3)

 

Sex

 Male

48 (18.9)

206 (81.1)

1

 

 Female

40 (20.8)

152 (79.2)

1.1 (0.7–1.8)

 

Site

 Guatemala City

3 (5.0)

57 (95.0)

1

1

 Santa Rosa

32 (19.8)

130 (80.2)

4.7 (1.4–15.0)

9.5 (1.8–50.2)

 Quetzaltenango

53 (23.7)

171 (76.3)

5.9 (1.8–19.6)

5.2 (0.9–29.7)

Ethnicity

 Latino

46 (16.7)

229 (83.3)

1

1

 Indigenous

42 (26.8)

115 (73.2)

1.8 (1.1–2.9)

4.3 (1.5–12.5)

Existing Chronic Disease

 No

19 (18.8)

82 (81.2)

1

 

 Yes

67 (20.2)

264 (79.8)

0.9 (0.5–1.6)

 

Pneumonia on Chest –X-ray (n = 239)

 No

19 (12.8)

129 (87.2)

1

1

 Yes

33 (36.3)

58 (63.7)

3.9 (2.0–7.4)

5.2 (2.5–11.0)

Antiviral treatment received (n = 268)

 No

1 (16.7)

5 (83.3)

1

 

 Yes

50 (19.1)

212 (80.9)

1.2 (0.1–10.3)

 

Type of flu

 A

74 (20.6)

286 (79.4)

1

 

 B

12 (14.6)

70 (85.4)

0.7 (0.3–1.3)

 

 A and B

2 (50.0)

2 (50.0)

3.9 (0.5–27.9)

 

Household Size

 1–4

21 (14.2)

127 (85.8)

1

 

 5–6

35 (20.4)

137 (79.7)

1.5 (0.9–2.8)

 

 7+

32 (28.6)

80 (71.4)

2.4 (1.3–4.5)

 

Sought care before hospitalization

 No

24 (13.3)

157 (86.7)

1

 

 Yes

62 (25.7)

179 (74.3)

2.3 (1.4–3.8)

 
  1. a Defined as requiring intensive care unit (ICU) admission or death
  2. bAdjusted for age, sex, and other variables in final model