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Table 3 Sensitivity and specificity of different diagnostic tools, using CRS as the reference test

From: Sensitivity and specificity of routine diagnostic work-up for tuberculosis in lung clinics in Yogyakarta, Indonesia: a cohort study

Diagnostic tool

Sensitivity (95%CI)

Specificity (95%CI)

Symptoms

Cough>2wks

97.1 (92.9–99.2)

10.6 (6.7–15.7)

Unintentional weight loss

84.3 (77.2–89.9)

53.3 (46.1–60.4)

Night sweats

69.3 (60.9–76.8)

64.8 (57.8–71.4)

Cough>2wks + weight loss

82.1 (74.8–88.1)

57.3 (50.1–64.3)

Cough> 2wks + night sweats

67.1 (58.7–74.8)

67.3 (60.4–73.8)

Weight loss + night sweats

65.0 (56.5–72.9)

76.9 (70.4–82.6)

All symptoms

62.9 (54.3–70.9)

78.4 (72.0–83.9)

Sputum Smear Microscopy (with Spot-Morning-Spot specimens)

Positive for AFB

81.4 (74–87.5)

99.5 (97.2–99.9)

Chest radiography (CXR)

Abnormalities suggestive of active TB

88.6 (82.1–93.3)

82.9 (77–87.9)

Combination

Cough>2wks + SSM

80.0 (72.4–86.3)

99.5 (97.2–99.9)

Cough>2wks + CXR

86.4 (79.6–91.6)

85.4 (79.8–90.0)

Weight loss+SSM

71.4 (63.2–78.7)

99.5 (97.2–99.9)

Weight loss+CXR

76.4 (68.5–83.2)

91.0 (86.1–94.6)

Night sweat+SSM

60.0 (51.4–68.2)

99.5 (97.2–99.9)

Night sweat+CXR

63.6 (55–71.5)

95.5 (91.6–97.9)

Cough>2wks + weight loss+SSM

70.0 (61.7–77.5)

99.5 (97.2–99.9)

Cough>2wks + weight loss+CXR

74.3 (66.2–81.3)

92.5 (87.9–95.7)

Cough>2wks + night sweat+SSM

58.6 (50–66.8)

99.5 (97.2–99.9)

Cough> 2wks + night sweat+CXR

61.4 (52.8–69.5)

96.0 (92.2–98.3)

Weight loss+night sweat+SSM

56.4 (47.8–64.8)

99.5 (97.2–99.9)

Weight loss+night sweat+CXR

59.3 (50.7–67.5)

96.5 (92.9–98.6)

All symptoms+SSM

55 (46.4–63.4)

99.5 (97.2–99.9)

All symptoms+CXR

57.1 (48.5–65.5)

97.0 (93.6–98.9)

SSM + CXR

78.6 (70.8–85.1)

99.5 (97.2–99.9)

Cough>2wks + SSM + CXR

77.1 (69.3–83.8)

99.5 (97.2–99.9)

Weight loss+SSM + CXR

68.6 (60.2–76.2)

99.5 (97.2–99.9)

Night sweat+SSM + CXR

58.6 (50–66.8)

99.5 (97.2–99.9)

Cough>2wks + weight loss+SSM + CXR

67.1 (58.7–74.8)

99.5 (97.2–99.9)

Cough>2wks + night sweat+SSM + CXR

57.1 (48.5–65.5)

99.5 (97.2–99.9)

Weight loss+night sweat+SSM + CXR

55.0 (46.4–63.4)

99.5 (97.2–99.9)

All symptoms+SSM + CXR

53.6 (45–62)

99.5 (97.2–99.9)