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Table 3 Sensitivity and specificity of different diagnostic tools, using CRS as the reference test

From: Sensitivity and specificity of routine diagnostic work-up for tuberculosis in lung clinics in Yogyakarta, Indonesia: a cohort study

Diagnostic tool Sensitivity (95%CI) Specificity (95%CI)
Symptoms
Cough>2wks 97.1 (92.9–99.2) 10.6 (6.7–15.7)
Unintentional weight loss 84.3 (77.2–89.9) 53.3 (46.1–60.4)
Night sweats 69.3 (60.9–76.8) 64.8 (57.8–71.4)
Cough>2wks + weight loss 82.1 (74.8–88.1) 57.3 (50.1–64.3)
Cough> 2wks + night sweats 67.1 (58.7–74.8) 67.3 (60.4–73.8)
Weight loss + night sweats 65.0 (56.5–72.9) 76.9 (70.4–82.6)
All symptoms 62.9 (54.3–70.9) 78.4 (72.0–83.9)
Sputum Smear Microscopy (with Spot-Morning-Spot specimens)
Positive for AFB 81.4 (74–87.5) 99.5 (97.2–99.9)
Chest radiography (CXR)
Abnormalities suggestive of active TB 88.6 (82.1–93.3) 82.9 (77–87.9)
Combination
Cough>2wks + SSM 80.0 (72.4–86.3) 99.5 (97.2–99.9)
Cough>2wks + CXR 86.4 (79.6–91.6) 85.4 (79.8–90.0)
Weight loss+SSM 71.4 (63.2–78.7) 99.5 (97.2–99.9)
Weight loss+CXR 76.4 (68.5–83.2) 91.0 (86.1–94.6)
Night sweat+SSM 60.0 (51.4–68.2) 99.5 (97.2–99.9)
Night sweat+CXR 63.6 (55–71.5) 95.5 (91.6–97.9)
Cough>2wks + weight loss+SSM 70.0 (61.7–77.5) 99.5 (97.2–99.9)
Cough>2wks + weight loss+CXR 74.3 (66.2–81.3) 92.5 (87.9–95.7)
Cough>2wks + night sweat+SSM 58.6 (50–66.8) 99.5 (97.2–99.9)
Cough> 2wks + night sweat+CXR 61.4 (52.8–69.5) 96.0 (92.2–98.3)
Weight loss+night sweat+SSM 56.4 (47.8–64.8) 99.5 (97.2–99.9)
Weight loss+night sweat+CXR 59.3 (50.7–67.5) 96.5 (92.9–98.6)
All symptoms+SSM 55 (46.4–63.4) 99.5 (97.2–99.9)
All symptoms+CXR 57.1 (48.5–65.5) 97.0 (93.6–98.9)
SSM + CXR 78.6 (70.8–85.1) 99.5 (97.2–99.9)
Cough>2wks + SSM + CXR 77.1 (69.3–83.8) 99.5 (97.2–99.9)
Weight loss+SSM + CXR 68.6 (60.2–76.2) 99.5 (97.2–99.9)
Night sweat+SSM + CXR 58.6 (50–66.8) 99.5 (97.2–99.9)
Cough>2wks + weight loss+SSM + CXR 67.1 (58.7–74.8) 99.5 (97.2–99.9)
Cough>2wks + night sweat+SSM + CXR 57.1 (48.5–65.5) 99.5 (97.2–99.9)
Weight loss+night sweat+SSM + CXR 55.0 (46.4–63.4) 99.5 (97.2–99.9)
All symptoms+SSM + CXR 53.6 (45–62) 99.5 (97.2–99.9)