Skip to main content

Table 6 Factors Associated with Mortality Among Children on ART at Livingstone Central Hospital (2003–2015)

From: Long-term survival outcomes of HIV infected children receiving antiretroviral therapy: an observational study from Zambia (2003–2015)

Predictor N Deaths Unadjusted Mortality HR (95% CI) p-value Adjusted Mortality HR (95% CI) p-value
Gender (N%)
 Male 519 33 Ref    
 Female 520 38 1.17 (0.7–1.9) 0.5207   
Baseline age
  < 1 year 179 29 5.4 (2.9–9.9) <.0001 3.1 (1.3–6.4) 0.0034
 1-5 years 387 25 1.9 (1.03–3.5) 0.0423 1.1 (0.6–2.3) 0.7529
 5–15 years 473 17 Ref   Ref  
Year of ART Initiation
 2003–2005 71 2 0.3 (0.03–2.7) 0.2778   
 2006–2009 512 43 2.1 (0.8–5.9) 0.1534   
 2010–2012 305 22 2.0 (0.7–5.9) 0.1948   
 2013–2014 151 4 Ref    
Nutritional status at baseline
 Wasted (WAZ < =-3SD) 182 17 Ref   Ref  
 WAZ > -3SD 857 54 0.59 (0.3–1.02) 0.0564 0.8 (0.6–1.5) 0.5141
CD4%
  < 15% 139 22 3.2 (0.9–10.8) 0.0561   
 15–25% 285 18 2.9 (0.8–9.9) 0.08   
  > =25% 225 3 Ref    
 missing 390 28 3.1 (0.9–10.2)    
Baseline Hemoglobin
  < =8 705 40 1.68 (1.05–2.69) 0.0295 1.2 (0.8–2.0) 0.4025
  > 8 334 31 Ref   Ref  
WHO stage at baseline
 stage 1 and 2 377 11 Ref   Ref  
 stage 3 471 29 2.05 (1.01–4.06) 0.0452 1.8 (0.9–3.6) 0.1188
 stage 4 177 29 6.41 (3.19–12.85) <.0001 4.8 (2.3–10) <.0001
 missing 14 0     
TB at baseline
 Yes 318 21 0.82 (0.54–1.49) 0.6645   
 No 721 50 Ref    
Regimen at baseline
 1NNRTI + 2NRTi’s 907 53 0.26 (0.14–0.46) <.0001 Ref  
 3 NRTI’s 54 4 0.37 (0.12–1.12) 0.0789 1.9 (0.9–3.7) 0.0603
 LPV/R based regimen 78 14 Ref   0.9 (0.3–2.6) 0.806
Mother took ART for PMTCT
 Yes 154 17 Ref   Ref  
 No 885 54 1.9 (1.2–3.4) 0.0139 1.0 (0.1–1.05) 0.0627
aChild know HIV status
Yes 191 4 0.21 (0.08–0.6) 0.0029 Ref  
No 848 67 Ref   0.4 (0.1–1.05)  
  1. aApplies to older children aged above 7 years’ old