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Table 2 Time to first cigarette and other risk factors for atherosclerosis in long-term heavy smokers

From: Nicotine dependence as an independent risk factor for atherosclerosis in the National Lung Screening Trial

Effect

Odds ratios and their 95% CIs

All matched samples

N = 166 cases, 286 controls

Aortic Atherosclerosisa

N = 95 cases, 164 controls

Coronary atherosclerosis only

N = 71 cases, 122 controls

TTFC

  ≤ 5 min

Reference

Reference

Reference

 6–29 min

0.72 (0.44–1.16)

0.54 (0.27–1.10)

0.9 (0.45–1.82)

 30–60 min

0.94 (0.49–1.82)

1.08 (0.46–2.52)

0.9 (0.29–2.74)

  > 60 min

0.49 (0.24–1.00)

0.24 (0.08–0.69)

1.27 (0.43–3.74)

BMI

0.95 (0.91–1.00)

0.93 (0.86–0.99)

0.98 (0.91–1.05)

Diabetes

1.45 (0.79–2.64)

0.58 (0.20–1.68)

2.58 (1.16–5.76)

Hypertension

1.78 (1.15–2.74)

2.34 (1.25–4.38)

1.36 (0.72–2.59)

Heart Attack

1.22 (0.70–2.13)

1.58 (0.71–3.52)

0.98 (0.42–2.29)

  1. All estimates were adjusted for the other covariates in the model. a Includes 40 cases with co-diagnosis of coronary atherosclerosis