Analysis | Outcomes | ∆C (95% CI) | ∆E (95% CI) | ICER | Distribution CE-plane (%) | ||||
---|---|---|---|---|---|---|---|---|---|
AUD | Points | AUD/point | NEc | SEd | SWe | NWf | |||
Primary analysisa | Societal perspective | QALYs | 1197 (−2962 to 6139) | 0.00 (−0.02 to 0.02) | 581,828 | 26.2 | 15.5 | 20.8 | 37.5 |
Pain intensity | 1197 (− 2945 to 6126) | 0.64 (−0.49 to 1.77) | 1858 | 6.2 | 5.8 | 30.3 | 57.6 | ||
Disability | 1197 (− 2884 to 6151) | 0.80 (−6.86 to 8.47) | 1495 | 21.7 | 19.4 | 17.0 | 41.9 | ||
Weight | 1197 (− 2941 to 6153) | -0.02 (−3.46 to 3.42) | −58,194 | 30.6 | 18.8 | 17.6 | 32.9 | ||
BMI | 1197 (− 2864 to 6122) | 0.11 (−1.16 to 1.39) | 10,455 | 26.8 | 16.1 | 20.3 | 36.8 | ||
Sensitivity analysisb | Per protocol | QALYs | − 958 (− 5801 to 2790) | 0.00 (−0.03 to 0.04) | −203,221 | 24.3 | 36.8 | 24.5 | 14.4 |
Pain intensity | −958 (− 5803 to 2869) | 0.70 (−0.75 to 2.15) | − 1370 | 6.3 | 10.9 | 50.6 | 32.2 | ||
Disability | −958 (− 5819 to 2792) | 1.21 (− 9.43 to 11.85) | −790 | 17.8 | 26.2 | 35.3 | 20.6 | ||
Weight | −958 (− 5782 to 2804) | 1.04 (−4.48 to 6.55) | − 922 | 13.1 | 22.8 | 38.6 | 25.5 | ||
BMI | −958 (− 5785 to 2884) | 0.62 (−1.42 to 2.65) | − 1553 | 10.3 | 18.4 | 43.1 | 28.1 | ||
Secondary analysisa | Healthcare perspective | QALYs | 798 (− 3175 to 5686) | −0.00 (−0.02 to 0.02) | −387,820 | 24.1 | 17.5 | 24.0 | 34.3 |
Pain intensity | 798 (− 3197 to 5835) | 0.64 (−0.49 to 1.78) | 1238 | 5.9 | 6.3 | 35.3 | 52.5 | ||
Disability | 798 (− 3203 to 5663) | 0.80 (−6.9 to 8.47) | 994 | 19.7 | 21.4 | 19.7 | 39.2 | ||
Weight | 798 (− 3234 to 5670) | −0.21 (− 3.46 to 3.42) | −38,598 | 28.4 | 21.4 | 19.8 | 30.3 | ||
BMI | 798 (− 3281 to 5618) | 0.11 (−1.16 to 1.39) | 6968 | 24.9 | 18.3 | 23.1 | 33.7 |