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Table 4 Multivariate logistic regression analysis for association between myocardial infarction or stroke, geographical region and risk factors

From: Regional differences of macrovascular disease in Northeast and South Germany: the population-based SHIP-TREND and KORA-F4 studies

Variable

Myocardial infarction or stroke (yes vs. no)

Known diabetesa

Myocardial infarction or stroke (yes vs. no)

General populationb

 

OR (95% Cl)

p-value

OR (95% Cl)

p-value

Model A

 SHIP-TREND (vs. KORA-F4)

1.14 (0.69–1.89)

0.600

1.34 (1.01–1.78)

0.004

 Men (vs. women)

2.05 (1.20–3.51)

0.009

2.58 (1.90–3.51)

< 0.001

 Age (per year, continuous)

1.07 (1.04–1.11)

< 0.001

1.10 (1.09–1.12)

< 0.001

Model B

 SHIP-TREND (vs. KORA-F4)

1.09 (0.62–1.94)

0.764

1.31 (0.95–1.79)

0.098

 Men (vs. women)

1.92 (0.96–3.84)

0.065

2.30 (1.60–3.31)

< 0.001

 Age (per year, continuous)

1.10 (1.05–1.14)

< 0.001

1.08 (1.06–1.10)

< 0.001

 BMI ≥ 25 kg/m2 (vs. <  25 kg/m2)

1.53 (0.38–6.23)

0.555

1.08 (0.66–1.80)

0.753

 BMI ≥ 30 kg/m2 (vs. <  25 kg/m2)

1.60 (0.40–6.36)

0.506

0.93 (0.55–1.58)

0.782

 hsCRP (mg/l)c (continuous)

1.30 (0.93–1.81)

0.121

1.09 (0.91–1.31)

0.344

 Hypertension (vs. no)

1.29 (0.35–4.67)

0.703

3.58 (2.08–6.19)

< 0.001

 Hyperlipidemia (vs. no)

4.27 (2.08–8.77)

< 0.001

4.76 (3.31–6.85)

< 0.001

 Smoker (vs. never smoker)

2.93 (1.18–7.27)

0.021

1.96 (1.17–3.29)

0.012

 Ex-smoker (vs. never-smoker)

1.48 (0.77–2.86)

0.243

1.69 (1.18–2.42)

0.004

 Low/middle education (vs. high education)

1.17 (0.52–2.64)

0.699

1.68 (1.08–2.61)

0.022

  < 1 h physical activity (vs. >  1 h)

0.80 (0.45–1.43)

0.451

1.16 (0.85–1.60)

0.355

Model C

 SHIP-TREND (vs. KORA-F4)

1.11 (0.66–1.87)

0.689

1.21 (0.89–1.64)

0.229

 Men (vs. women)

1.74 (0.96–3.16)

0.071

2.23 (1.58–3.14)

< 0.001

 Age (per year, continuous)

1.08 (1.04–1.12)

< 0.001

1.08 (1.06–1.09)

< 0.001

 Hypertension (vs. no)

2.07 (0.61–7.08)

0.245

3.32 (1.99–5.56)

< 0.001

 Hyperlipidemia (vs. no)

4.28 (2.21–8.26)

< 0.001

4.74 (3.35–6.72)

< 0.001

 Smoker (vs. never smoker)

1.89 (0.82–4.35)

0.136

1.72 (1.05–2.81)

0.031

 Ex-smoker (vs. never-smoker)

1.35 (0.76–2.42)

0.311

1.62 (1.16–2.27)

0.005

 Low/middle education (vs. high education)

1.43 (0.66–3.13)

0.369

1.70 (1.12–2.58)

0.013

 Known diabetes (vs. normal glucose tolerance)

–

–

1.37 (0.91–2.06)

0.130

 Prediabetes (vs. normal glucose tolerance)

–

–

0.93 (0.63–1.36)

0.696

 Newly diagnosed diabetes (vs. normal glucose tolerance)

–

–

0.94 (0.49–1.81)

0.862

  1. BMI body mass index, OR odds ratio, CI confidence interval
  2. aSHIP-TREND: N = 47, KORA-F4: N = 31
  3. bSHIP-TREND: N = 105, KORA-F4: N = 109
  4. cHigh-sensitivity C - reactive protein. Participants with hsCRP > 10 mg/l were excluded, SHIP-TREND: N = 175, KORA-F4: N = 112
  5. Significant regional differences (p < 0.05) are highlighted in bold
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BMC Public Health

ISSN: 1471-2458

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