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Table 3 Multivariate logistic regression analysis for association between macrovascular disease, geographical region and risk factors in people with known diabetes and in the general population

From: Regional differences of macrovascular disease in Northeast and South Germany: the population-based SHIP-TREND and KORA-F4 studies

Variable

Macrovascular disease (yes vs. no)

Known diabetes

Macrovascular disease (yes vs. no)

General population

OR (95% Cl)

p-value

OR (95% Cl)

p-value

Model A

 SHIP-TREND (vs. KORA-F4)

1.66 (1.14–2.43)

0.009

1.76 (1.46–2.12)

< 0.001

 Men (vs. women)

1.73 (1.18–2.52)

0.005

2.20 (1.81–2.67)

< 0.001

 Age (per year, continuous)

1.05 (1.03–1.07)

< 0.001

1.09 (1.08–1.10)

< 0.001

Model B

 SHIP-TREND (vs. KORA-F4)

1.70 (1.11–2.62)

0.015

1.78 (1.44–2.19)

< 0.001

 Men (vs. women)

1.50 (0.93–2.41)

0.098

1.97 (1.57–2.47)

< 0.001

 Age (per year, continuous)

1.05 (1.02–1.08)

0.001

1.07 (1.05–1.08)

< 0.001

 BMI ≥ 25 kg/m2 (vs. <  25 kg/m2)

2.55 (0.85–7.65)

0.096

1.39 (1.01–1.93)

0.046

 BMI ≥ 30 kg/m2 (vs. <  25 kg/m2)

1.91 (0.65–5.64)

0.241

1.14 (0.80–1.61)

0.466

 hsCRP (mg/l)a (continuous)

1.15 (0.90–1.47)

0.254

1.04 (0.92–1.17)

0.534

 Hypertension (vs. no)

2.35 (0.94–5.88)

0.069

3.47 (2.57–4.68)

< 0.001

 Hyperlipidemia (vs. no)

3.86 (2.41–6.18)

< 0.001

3.34 (2.70–4.14)

< 0.001

 Smoker (vs. never smoker)

1.47 (0.73–2.97)

0.278

1.16 (0.81–1.64)

0.417

 Ex-smoker (vs. never-smoker)

1.58 (0.98–2.55)

0.061

1.45 (1.15–1.84)

0.002

 Low/middle education (vs. high education)

0.92 (0.51–1.64)

0.767

1.22 (0.94–1.59)

0.134

  < 1 h physical activity (vs. >  1 h)

0.96 (0.62–1.47)

0.837

1.01 (0.82–1.24)

0.945

Model C

 SHIP-TREND (vs. KORA-F4)

1.66 (1.11–2.49)

0.014

1.63 (1.33–2.00)

< 0.001

 Men (vs. women)

1.49 (0.97–2.29)

0.070

1.89 (1.52–2.34)

< 0.001

 Age (per year, continuous)

1.05 (1.02–1.08)

0.001

1.06 (1.05–1.08)

< 0.001

 BMI ≥ 25 kg/m2 (vs. <  25 kg/m2)

1.85 (0.67–5.10)

0.237

1.39 (1.01–1.92)

0.041

 BMI ≥ 30 kg/m2 (vs. <  25 kg/m2)

1.72 (0.64–4.66)

0.287

1.15 (0.82–1.61)

0.419

 Hypertension (vs. no)

2.79 (1.13–6.87)

0.026

3.48 (2.59–4.68)

< 0.001

 Hyperlipidemia (vs. no)

3.48 (2.25–5.36)

< 0.001

3.16 (2.57–3.88)

< 0.001

 Smoker (vs. never smoker)

1.27 (0.66–2.45)

0.477

1.10 (0.79–1.54)

0.572

 Ex-smoker (vs. never-smoker)

1.51 (0.97–2.34)

0.066

1.48 (1.18–1.86)

0.001

 Known diabetes (vs. normal glucose tolerance)

–

–

1.37 (1.03–1.84)

0.033

 Prediabetes (vs. normal glucose tolerance)

–

–

0.86 (0.67–1.10)

0.226

 Newly diagnosed diabetes (vs. normal glucose tolerance)

–

–

0.99 (0.64–1.52)

0.950

  1. BMI body mass index, OR odds ratio, CI confidence interval
  2. aHigh-sensitivity C - reactive protein. Participants with hsCRP > 10 mg/l were excluded, SHIP-TREND: N = 175, KORA-F4: N = 112
  3. Significant regional differences (p < 0.05) are highlighted in bold
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BMC Public Health

ISSN: 1471-2458

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