Skip to main content

Table 4 Interaction effects of obesity and reproductive and hormone factors on knee pain and clinical KOA

From: Combined effects of reproductive and hormone factors and obesity on the prevalence of knee osteoarthritis and knee pain among middle-aged or older Chinese women: a cross-sectional study

Variables

Knee pain

Clinical KOA

OR (95% CI)

Multiplicative

interaction, p-value

Additive

interaction, AP

OR (95% CI)

Multiplicative interaction, p-value

Additive interaction, AP

BMI + pregnancy

 

0.570

0.08(0.07, 0.22)*

 

0.946

−0.02(−0.31, 0.27)

 BMI (−) pregnancy (< 3)

1

  

1

  

 BMI (−) pregnancy (≥3)

1.16(1.01–1.33)*

  

1.00(0.76–1.33)

  

 BMI (+) pregnancy (< 3)

1.48(1.27–1.73)*

  

1.65(1.24–2.21)*

  

 BMI (+) pregnancy (≥3)

1.78(1.55–2.04)*

  

1.63(1.26–2.12)*

  

BMI + abortion

 

0.544

0.07(−0.08, 0.23)

 

0.288

−0.14(− 0.42, 0.15)

 BMI (−) abortion (−)

1

  

1

  

 BMI (−) abortion (+)

1.06(0.92–1.23)

  

1.20(0.90–1.60)

  

 BMI (+) abortion (−)

1.48(1.25–1.74)*

  

1.90(1.42–2.55)*

  

 BMI (+) abortion (+)

1.66(1.44–1.92)*

  

1.85(1.40–2.42)*

  

BMI + menopause

 

0.329

0.18(−0.05, 0.41)

 

0.298

−0.15(− 0.67, 0.38)

 BMI (−) menopause (−)

1

  

1

  

 BMI (−) menopause (+)

1.20(0.93–1.54)

  

2.08(0.96–4.51)

  

 BMI (+) menopause (−)

1.32(0.94–1.85)

  

2.73(1.09–6.88)*

  

 BMI (+) menopause (+)

1.84(1.43–2.38)*

  

3.32(1.53–7.20)*

  

BMI + HT

 

0.828

0.09(−0.33, 0.51)

 

0.916

0.20(− 0.33, 0.74)

 BMI (−) HT (−)

1

  

1

  

 BMI (−) HT (+)

1.62(1.14–2.32)*

  

1.72(0.93–3.17)

  

 BMI (+) HT (−)

1.52(1.39–1.67)*

  

1.62(1.37–1.93)*

  

 BMI (+) HT (+)

2.36(1.62–3.44)*

  

2.95(1.77–4.92)*

  

BMI + contraceptives use

 

0.019*

0.26(0.11–0.42)*

 

0.133

−0.16(−0.54, 0.22)

 BMI (−) contraceptives (−)

1

  

1

  

 BMI (−) contraceptives (+)

1.03(0.87–1.22)

  

1.52(1.12–2.06)*

  

 BMI (+) contraceptives (−)

1.44(1.30–1.59)*

  

1.74(1.44–2.11)*

  

 BMI (+) contraceptives (+)

2.00(1.68–2.38)*

  

1.96(1.46–2.62)*

  
  1. AP attributable proportion of interaction, HT, post-menopausal hormone replacement therapy, BMI (+) ≥24.0 kg/m2, BMI (−) < 24.0 kg/m2, Adjusted for age (continuous), education level, alcohol consumption, physical exercise, work posture, and shift work. *p-value < 0.05
Back to article page

BMC Public Health

ISSN: 1471-2458

Contact us