| Subgroup analyses | Results from meta-regression | |||||||
---|---|---|---|---|---|---|---|---|---|
Results | Heterogeneity | ||||||||
Variable | Subgroup | Number of studies | OR | 95% CI | P-value | I 2 | Coefficient | SD | P-value |
Outcome measurement | Mixed | 2 | 1.224 | 0.895–1.674 | 0.800 | 0% | Reference | ||
Formal | 9 (13 different samples) | 1.061 | 0.907–1.243 | 0.000 | 89% | −0.1424 | 0.2379 | 0.550 | |
Proportion of volunteers (%) in baseline study sample | Continuous | 9a (13 different samples) | 1.099 | 0.917–1.317 | 0.000 | 89% | 0.0004 | 0.0003 | 0.177 |
0–100% | 8 | 1.038 | 0.805–1.268 | 0.000 | 93% | Reference |  |  | |
0% | 2 (3 different samples) | 0.918 | 0.808–1.043 | 0.836 | 0% | −0.0689 | 0.2266 | 0.761 | |
100% | 3 (4 different samples) | 1.306 | 1.000–1.705 | 0.296 | 19% | 0.2926 | 0.2156 | 0.175 | |
Mean age at baseline | Continuous | 10b (13 different samples) | 1.109 | 0.920–1.337 | 0.000 | 86% | −0.0000 | 0.0006 | 0.952 |
≤ 55 years | 6 (8 different samples) | 1.136 | 0.939–1.374 | 0.000 | 85% | Reference |  |  | |
>  55 years | 6 (7 different samples) | 1.023 | 0.765–1.367 | 0.000 | 90% | −0.1296 | 0.1695 | 0.445 | |
Continent | USA | 6 | 1.279 | 1.120–1.460 | 0.063 | 52% | Reference | ||
Europe | 5 (9 different samples) | 0.906 | 0.770–1.067 | 0.000 | 77% | −0.3531 | 0.1135 | 0.002 | |
Year of baseline measurement | Continuous | 11c (15 different samples) | 1.078 | 0.931–1.249 | 0.000 | 88% | 0.0008 | 0.0126 | 0.951 |
<  2006 | 9 (11 different samples) | 1.083 | 0.924–1.270 | 0.000 | 91% | Reference |  |  | |
≥ 2006 | 3 (4 different samples) | 1.084 | 0.775–1.516 | 0.474 | 0% | −0.0301 | 0.2334 | 0.897 | |
Risk of bias items | |||||||||
 Study participation | Unclear/high risk of bias | 9 (11 different samples) | 1.025 | 0.871–1.205 | 0.000 | 89% | Reference | ||
Low risk of bias | 3 (4 different samples) | 1.288 | 1.094–1.515 | 0.383 | 2% | 0.2436 | 0.1809 | 0.178 | |
 Study confounding | Unclear/high risk of bias | 1 | 1.174 | 0.748–1.842 | N.A. | N.A. | Reference | ||
Low risk of bias | 10 (14 different samples) | 1.073 | 0.922–1.250 | 0.000 | 89% | −0.0898 | 0.3302 | 0.786 |