Outcome measurement
|
Mixed
|
2
|
0.986
|
0.959–1.013
|
0.037
|
77%
|
Reference
|
Formal
|
9 (12 different samples)
|
0.969
|
0.946–0.992
|
0.000
|
89%
|
−0.0168
|
0.0251
|
0.504
|
Determinant measurement
|
Dichotomous
|
1 (2 different samples)
|
0.485
|
0.385–0.611
|
0.248
|
25%
|
Reference
|
Continuous
|
10 (12 different samples)
|
0.983
|
0.969–0.996
|
0.000
|
78%
|
0.7122
|
0.1014
|
0.000
|
Proportion of volunteers (%) in baseline study sample
|
Continuous
|
10a (13 different samples)
|
0.970
|
0.950–0.991
|
0.000
|
88%
|
0.0000
|
0.0001
|
0.591
|
0–100%
|
9 (11 different samples)
|
0.985
|
0.971–0.999
|
0.000
|
79%
|
Reference
| | |
0%
|
1
|
0.440
|
0.343–0.565
|
N.A.
|
N.A.
|
−0.8053
|
0.1292
|
0.000
|
100%
|
2
|
0.747
|
0.444–1.256
|
0.001
|
91%
|
−0.0500
|
0.0292
|
0.087
|
Mean age at baseline
|
Continuous
|
10b (12 different samples)
|
0.983
|
0.969–0.996
|
0.000
|
78%
|
−0.0000
|
0.0000
|
0.200
|
≤ 55 years
|
5 (6 different samples)
|
0.991
|
0.975–1.007
|
0.000
|
79%
|
Reference
| | |
> 55 years
|
6 (8 different samples)
|
0.944
|
0.904–0.986
|
0.000
|
89%
|
−0.0296
|
0.0198
|
0.135
|
Continent
|
USA
|
6
|
0.978
|
0.959–0.998
|
0.001
|
77%
|
Reference
|
Europe
|
5 (8 different samples)
|
0.966
|
0.933–1.000
|
0.000
|
91%
|
−0.0026
|
0.0210
|
0.900
|
Year of baseline measurement
|
Continuous
|
11 (14 different samples)
|
0.989
|
0.984–0.995
|
0.000
|
87%
|
0.0006
|
0.0014
|
0.686
|
< 2006
|
8 (10 different samples)
|
0.970
|
0.948–0.993
|
0.000
|
91%
|
Reference
| | |
≥ 2006
|
3 (4 different samples)
|
0.975
|
0.959–0.991
|
0.388
|
1%
|
0.0110
|
0.0230
|
0.631
|
Risk of bias items
|
Study participation
|
Unclear/high risk of bias
|
9 (12 different samples)
|
0.975
|
0.956–0.995
|
0.000
|
88%
|
Reference
|
Low risk of bias
|
2
|
0.858
|
0.623–1.192
|
0.000
|
93%
|
−0.0099
|
0.0315
|
0.754
|
Study confounding
|
Unclear/high risk of bias
|
1
|
1.000
|
0.981–1.020
|
N.A.
|
N.A.
|
Reference
|
Low risk of bias
|
10 (13 different samples)
|
0.970
|
0.950–0.991
|
0.000
|
88%
|
−0.0303
|
0.0331
|
0.360
|