White blood cell count and all-cause and cause-specific mortality in the Guangzhou biobank cohort study

BMC Public Health

Table 4 Association between the baseline white blood cell count and respiratory disease mortality in the Guangzhou Biobank Cohort Study, 2003–2016, excluding deaths within 2 years

Decile of WBC count, ×10⁹/L (range)	Multivariable model^a (n = 29,672)		Multivariable model in non-smokers ^a (n = 23,958)
Decile of WBC count, ×10⁹/L (range)	HR (95% CI)	P value	HR (95% CI)	P value
1st decile (f < 4. 5; m < 4.7)	1.28 (0.68, 2.41)	0.44	1.20 (0.52, 2.80)	0.67
2nd decile (f 4.5–4.8; m 4.7–5.2)	1.21 (0.65, 2.25)	0.56	1.07 (0.45, 2.54)	0.88
3rd decile (f 4.9–5.3; m 5.3–5.7)	Reference		Reference
4th decile (f 5.4–5.6; m 5.8–6.0)	1.50 (0.83, 2.72)	0.18	1.51 (0.69, 3.31)	0.31
5th decile (f 5.7–6.0; m 6.1–.4)	1.39 (0.78, 2.51)	0.27	1.45 (0.67, 3.14)	0.35
6th decile (f 6.1–6.3; m 6.5–6.8)	1.49 (0.81, 2.73)	0.20	1.74 (0.79, 3.85)	0.17
7th decile (f 6.4–6.8; m 6.9–7.2)	1.36 (0.75, 2.46)	0.31	1.39 (0.64, 3.03)	0.40
8th decile (f 6.9–7.3; m 7.3–7.8)	1.89 (1.08, 3.31)	0.03	1.91 (0.90, 4.04)	0.09
9th decile (f 7.4–8.2; m 7.9–8.7)	1.99 (1.13, 3.48)	0.02	2.13 (1.01, 4.48)	0.05
10th decile (f > 8.2; m > 8.8)	1.90 (1.08, 3.33)	0.03	1.79 (0.83, 3.84)	0.14

^a: adjusted for age, sex, education, occupation, smoking status, alcohol use, physical activity, self-rated health, body mass index, diabetes, triglycerides, high-density lipoprotein cholesterol, platelet count, haemoglobin, force vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and self-reported respiratory disease (COPD, chronic bronchitis, emphysema, asthma, tuberculosis, pneumonia)

ISSN: 1471-2458