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Table 3 Association between the baseline white blood cell count and cancer and respiratory disease mortality in the Guangzhou Biobank Cohort Study, 2003–2016

From: White blood cell count and all-cause and cause-specific mortality in the Guangzhou biobank cohort study

Decile of WBC count, ×109/L (range) Age, sex-adjusted results (n = 29,925) Multivariable adjusteda (n = 29,925) Further excluding deaths within 2 yearsa (n = 29,672)
HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value
Cancer mortality (no. of deaths = 1153)
 1st decile (f < 4. 5; m < 4.7) 1.33 (1.01, 1.75) 0.04 1.33 (1.00, 1.77) 0.05 1.29 (0.95, 1.75) 0.10
 2nd decile (f 4.5–4.8; m 4.7–5.2) 1.50 (1.15, 1.97) 0.003 1.54 (1.17, 2.03) 0.002 1.52 (1.14, 2.03) 0.005
 3rd decile (f 4.9–5.3; m 5.3–5.7) Reference   Reference   Reference  
 4th decile (f 5.4–5.6; m 5.8–6.0) 1.05 (0.79, 1.40) 0.74 1.05 (0.78, 1.41) 0.75 1.10 (0.81, 1.50) 0.52
 5th decile (f 5.7–6.0; m 6.1–.4) 1.23 (0.94, 1.61) 0.13 1.20 (0.91, 1.58) 0.20 1.19 (0.89, 1.58) 0.25
 6th decile (f 6.1–6.3; m 6.5–6.8) 1.02 (0.76, 1.37) 0.91 1.03 (0.76, 1.39) 0.86 0.99 (0.72, 1.36) 0.94
 7th decile (f 6.4–6.8; m 6.9–7.2) 1.15 (0.88, 1.52) 0.30 1.14 (0.86, 1.51) 0.35 1.11 (0.83, 1.49) 0.49
 8th decile (f 6.9–7.3; m 7.3–7.8) 1.37 (1.05, 1.78) 0.02 1.30 (0.99, 1.71) 0.06 1.28 (0.96, 1.70) 0.10
 9th decile (f 7.4–8.2; m 7.9–8.7) 1.36 (1.04, 1.77) 0.02 1.24 (0.94, 1.63) 0.14 1.25 (0.94, 1.67) 0.13
 10th decile (f > 8.2; m > 8.8) 1.27 (0.97, 1.66) 0.09 1.13 (0.85, 1.50) 0.41 1.13 (0.84, 1.52) 0.42
Respiratory disease mortality (no. of deaths = 325)
 1st decile (f < 4. 5; m < 4.7) 1.23 (0.69, 2.19) 0.49 1.09 (0.59, 1.99) 0.78 1.16 (0.62, 2.17) 0.64
 2nd decile (f 4.5–4.8; m 4.7–5.2) 1.19 (0.66, 2.14) 0.55 1.23 (0.68, 2.22) 0.50 1.30 (0.70, 2.40) 0.41
 3rd decile (f 4.9–5.3; m 5.3–5.7) Reference   Reference   Reference  
 4th decile (f 5.4–5.6; m 5.8–6.0) 1.36 (0.78, 2.37) 0.28 1.41 (0.80, 2.50) 0.24 1.55 (0.86, 2.79) 0.15
 5th decile (f 5.7–6.0; m 6.1–.4) 1.44 (0.84, 2.47) 0.19 1.52 (0.87, 2.64) 0.14 1.50 (0.83, 2.68) 0.18
 6th decile (f 6.1–6.3; m 6.5–6.8) 1.41 (0.80, 2.49) 0.23 1.47 (0.82, 2.65) 0.20 1.61 (0.88, 2.95) 0.12
 7th decile (f 6.4–6.8; m 6.9–7.2) 1.47 (0.85, 2.52) 0.17 1.55 (0.89, 2.72) 0.12 1.53 (0.85, 2.76) 0.16
 8th decile (f 6.9–7.3; m 7.3–7.8) 2.07 (1.24, 3.45) 0.005 2.19 (1.29, 3.72) 0.004 2.28 (1.31, 3.95) 0.003
 9th decile (f 7.4–8.2; m 7.9–8.7) 1.99 (1.19, 3.34) 0.01 2.25 (1.32, 3.85) < 0.001 2.26 (1.29, 3.95) < 0.001
 10th decile (f > 8.2; m > 8.8) 2.32 (1.41, 3.84) 0.001 2.52 (1.49, 4.27) 0.001 2.51 (1.45, 4.35) 0.001
  1. a adjusted for age, sex, education, occupation, smoking status, alcohol use, physical activity, self-rated health, body mass index, diabetes, triglycerides, high-density lipoprotein cholesterol, platelet count and haemoglobin