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Table 2 Association between baseline white blood cell count and total mortality and coronary heart disease (CHD) mortality in the Guangzhou Biobank Cohort Study, 2003–2016

From: White blood cell count and all-cause and cause-specific mortality in the Guangzhou biobank cohort study

Decile of WBC count, ×109/L (range) Age, sex-adjusted results (n = 29,925) Multivariable adjusteda (n = 29,925) Further excluding deaths within 2 yearsa (n = 29,672)
HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value
Total mortality (no. of deaths = 2997)
 1st decile (f < 4.5; m < 4.7) 1.36 (1.14, 1.63) 0.001 1.31 (1.09, 1.58) 0.005 1.20 (0.99, 1.46) 0.07
 2nd decile (f 4.5–4.8; m 4.7–5.2) 1.32 (1.10, 1.58) 0.003 1.33 (1.10, 1.60) 0.003 1.26 (1.04, 1.53) 0.02
 3rd decile (f 4.9–5.3; m 5.3–5.7) 1.06 (0.88, 1.28) 0.51 1.05 (0.87, 1.27) 0.63 0.97 (0.80, 1.18) 0.77
 4th decile (f 5.4–5.6; m 5.8–6.0) Reference   Reference   Reference  
 5th decile (f 5.7–6.0; m 6.1–.4) 1.30 (1.09, 1.54) 0.004 1.29 (1.08, 1.55) 0.005 1.21 (1.00, 1.46) 0.04
 6th decile (f 6.1–6.3; m 6.5–6.8) 1.13 (0.94, 1.37) 0.20 1.14 (0.94, 1.38) 0.20 1.09 (0.90, 1.34) 0.38
 7th decile (f 6.4–6.8; m 6.9–7.2) 1.36 (1.14, 1.62) 0.001 1.36 (1.13, 1.63) 0.001 1.28 (1.06, 1.53) 0.009
 8th decile (f 6.9–7.3; m 7.3–7.8) 1.56 (1.31, 1.85) < 0.001 1.50 (1.26, 1.79) < 0.001 1.41 (1.17, 1.69) < 0.001
 9th decile (f 7.4–8.2; m 7.9–8.7) 1.68 (1.42, 1.99) < 0.001 1.58 (1.32, 1.88) < 0.001 1.48 (1.23, 1.77) < 0.001
 10th decile (f > 8.2; m > 8.8) 1.96 (1.66, 2.31) < 0.001 1.83 (1.54, 2.17) < 0.001 1.72 (1.44, 2.05) < 0.001
CHD mortality (no. of deaths = 459)b
 1st decile (f < 4.5; m < 4.7) 1.48 (0.85, 2.57) 0.16 1.54 (0.87, 2.71) 0.14 1.48 (0.84, 2.61) 0.18
 2nd decile (f 4.5–4.8; m 4.7–5.2) 1.20 (0.67, 2.15) 0.55 1.28 (0.70, 2.31) 0.42 1.22 (0.67, 2.22) 0.52
 3rd decile (f 4.9–5.3; m 5.3–5.7) 1.47 (0.86, 2.52) 0.16 1.40 (0.80, 2.44) 0.24 1.40 (0.80, 2.43) 0.24
 4th decile (f 5.4–5.6; m 5.8–6.0) Reference   Reference   Reference  
 5th decile (f 5.7–6.0; m 6.1–.4) 1.51 (0.89, 2.57) 0.13 1.48 (0.86, 2.55) 0.16 1.34 (0.77, 2.34) 0.30
 6th decile (f 6.1–6.3; m 6.5–6.8) 1.58 (0.91, 2.74) 0.11 1.58 (0.90, 2.78) 0.11 1.60 (0.91, 2.81) 0.10
 7th decile (f 6.4–6.8; m 6.9–7.2) 1.85 (1.11, 3.10) 0.02 1.78 (1.05, 3.02) 0.03 1.74 (1.02, 2.95) 0.04
 8th decile (f 6.9–7.3; m 7.3–7.8) 2.40 (1.46, 3.95) 0.001 2.27 (1.36, 3.78) 0.002 2.13 (1.27, 3.56) 0.004
 9th decile (f 7.4–8.2; m 7.9–8.7) 1.74 (1.03, 2.93) 0.04 1.62 (0.95, 2.78) 0.08 1.56 (0.90, 2.68) 0.11
 10th decile (f > 8.2; m > 8.8) 3.45 (2.15, 5.55) < 0.001 3.02 (1.84, 4.98) < 0.001 2.86 (1.73, 4.73) < 0.001
  1. a adjusted for age, sex, education, occupation, smoking status, alcohol use, physical activity, self-rated health, body mass index, diabetes, triglycerides, high-density lipoprotein cholesterol, platelet count and haemoglobin
  2. b 1528 participant with vascular disease at baseline including coronary heart disease, stroke, angina, myocardial infarction and peripheral vascular disease were excluded