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Table 3 Effect of intervention on blood lipids and insulin resistance (ITT)

From: Effects of alternate day calorie restriction and exercise on cardio-metabolic risk factors in overweight and obese adults: an exploratory randomized controlled study

Variables

Group

Baseline

Week 8

Change

p-value

Insulin (μIU/ml)

E-ADCR (n = 12)

9.4 ± 3.6

6.5 ± 3.0b

− 2.9 ± 4.1

0.205

ADCR (n = 13)

9.3 ± 4.1

11.8 ± 12.9

2.6 ± 11.5

Exercise (n = 10)

7.5 ± 3.6

7.6 ± 3.5

0.1 ± 3.5

Control (n = 10)

8.5 ± 6.2

11.0 ± 7.7

2.6 ± 4.0

Glucose (mg/dl)

E-ADCR (n = 12)

98.0 ± 17.0

87.08 ± 12.70b

−10.9 ± 16.9

0.110

ADCR (n = 13)

90.0 ± 9.5

87.0 ± 8.1

−3.0 ± 9.4

Exercise (n = 10)

93.0 ± 8.0

92.3 ± 7.2

−0.7 ± 8.3

Control (n = 10)

87.0 ± 5.4

86.0 ± 5.7

− 1.0 ± 5.0

HOMA-IR

E-ADCR (n = 12)

2.4 ± 1.4

1.4 ± 0.8b

− 0.9 ± 1.3

0.132

ADCR (n = 13)

2.1 ± 1.0

2.7 ± 3.3

0.6 ± 2.8

Exercise (n = 10)

1.7 ± 0.9

1.8 ± 0.9

0.0 ± 0.8

Control (n = 10)

1.8 ± 1.4

2.4 ± 1.7

0.5 ± 0.9

TG (mg/dl)

E-ADCR (n = 12)

133.4 ± 47.1

89.7 ± 33.7a

− 43.8 ± 41.9c, d

0.004

ADCR (n = 13)

108.8 ± 48.7

120.8 ± 80.6

12.0 ± 56.2

Exercise (n = 10)

142.7 ± 78.3

106.9 ± 42.7

− 35.8 ± 55.8

Control (n = 10)

109.5 ± 86.8

130.7 ± 86.8

21.2 ± 31.0

TC (mg/dl)

E-ADCR (n = 12)

182.8 ± 26.0

197.1 ± 28.6

14.3 ± 22.9

0.475

ADCR (n = 13)

189.9 ± 23.91

193.9 ± 21.6

4.1 ± 19.6

Exercise (n = 10)

177.8 ± 33.4

191.9 ± 36.4

14.1 ± 25.3

Control (n = 10)

178.5 ± 38.0

194.8 ± 37.4a

16.3 ± 13.6

HDL-C (mg/dl)

E-ADCR (n = 12)

48.0 ± 10.4

53.3 ± 10.5b

5.3 ± 8.1

0.622

ADCR (n = 13)

58.5 ± 15.0

61.1 ± 15.4

2.6 ± 8.3

Exercise (n = 10)

44.8 ± 10.0

51.5 ± 8.6b

6.7 ± 8.5

Control (n = 10)

54.6 ± 11.8

59.4 ± 12.4b

4.9 ± 4.7

  1. Data are presented as mean ± SD
  2. E-ADCR Exercise plus alternate day calorie restriction, ADCR Alternate day calorie restriction, BMI Body mass index, WC Waist circumference, SBP Systolic blood pressure, DBP Diastolic blood pressure, HR Heart rate, HOMA-IR Homeostasis model assessment-insulin resistance, TG Triglycerides, TC Total cholesterol, HDL-C High-density lipoprotein cholesterol
  3. aSignificantly different between baseline and week 8, p < 0.01
  4. bSignificantly different between baseline and week 8, p < 0.05
  5. cSignificantly different with the control group, p < 0.05
  6. dSignificantly different with the ADCR group, p < 0.05; p values were obtained by One-way ANOVA with Tukey post-hoc analysis