Variables | All (n = 1004) | Group 0 (n = 487) | Group 1 (n = 178) | Group 2 (n = 339) | p-value | |||
---|---|---|---|---|---|---|---|---|
all | Group 0 vs. Group 1 | Group 0 vs. Group 2 | Group 1 vs. Group 2 | |||||
Clinical parameters | ||||||||
Age, years | 53 ± 10 | 55 ± 11 | 50 ± 9 | 51 ± 9 | < 0.001 | < 0.001 | < 0.001 | 0.539 |
Male sex, n (%) | 721 (72) | 330 (68) | 77 (43) | 314 (93) | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Diabetes mellitus, n (%) | 92 (9) | 51 (10) | 9 (5) | 32 (9) | 0.106 | 0.033 | 0.724 | 0.089 |
Hypertension, n (%) | 254 (25) | 124 (32) | 30 (17) | 100 (29) | 0.008 | 0.022 | 0.204 | 0.002 |
Smoking, n (%) | 487 (49) | 181 (37) | 59 (33) | 247 (73) | < 0.001 | 0.464 | < 0.001 | < 0.001 |
Body mass index (kg/m2) | 25 ± 3 | 25 ± 3 | 24 ± 3 | 25 ± 3 | < 0.001 | 0.031 | 0.082 | < 0.001 |
Systolic BP (mmHg) | 123 ± 14 | 123 ± 14 | 120 ± 16 | 125 ± 14 | < 0.001 | 0.034 | 0.042 | < 0.001 |
Diastolic BP (mmHg) | 76 ± 11 | 75 ± 10 | 74 ± 11 | 80 ± 10 | < 0.001 | 0.131 | < 0.001 | < 0.001 |
Laboratory parameters | ||||||||
Fasting glucose (mg/dL) | 94 ± 23 | 93 ± 22 | 91 ± 22 | 97 ± 24 | 0.008 | 0.580 | 0.037 | 0.013 |
HbA1c (%) | 5.7 ± 0.8 | 5.8 ± 0.9 | 5.6 ± 0.8 | 5.7 ± 0.7 | 0.191 | 0.164 | 0.847 | 0.369 |
Blood urea nitrogen (mg/dL) | 14 ± 4 | 15 ± 4 | 14 ± 4 | 14 ± 4 | 0.207 | 0.229 | 0.462 | 0.794 |
Creatinine (mg/dL) | 0.8 ± 0.3 | 0.8 ± 0.2 | 0.7 ± 0.2 | 0.9 ± 0.4 | < 0.001 | 0.027 | 0.004 | < 0.001 |
Aspartate transaminase (U/L) | 29 ± 21 | 28 ± 14 | 26 ± 11 | 32 ± 32 | 0.001 | 0.528 | 0.004 | 0.002 |
Alanine transaminase (U/L) | 33 ± 31 | 32 ± 26 | 28 ± 20 | 36 ± 39 | 0.011 | 0.293 | 0.125 | 0.010 |
Alkaline phosphatase (U/L) | 62 ± 17 | 64 ± 17 | 61 ± 15 | 60 ± 17 | 0.003 | 0.073 | 0.004 | 0.923 |
Gamma-glutamyl transferase (U/L) | 53 ± 76 | 38 ± 39 | 38 ± 62 | 83 ± 108 | < 0.001 | 0.993 | < 0.001 | < 0.001 |
Uric acid (mg/dL) | 5.8 ± 1.6 | 5.6 ± 1.4 | 5.4 ± 1.4 | 6.3 ± 1.7 | < 0.001 | 0.250 | < 0.001 | < 0.001 |
Total cholesterol (mg/dL) | 196 ± 38 | 193 ± 37 | 198 ± 41 | 197 ± 36 | 0.232 | 0.327 | 0.362 | 0.949 |
Triglyceride (mg/dL) | 138 ± 107 | 125 ± 78 | 125 ± 126 | 163 ± 125 | < 0.001 | 0.998 | < 0.001 | < 0.001 |
High-density lipoprotein (mg/dL) | 50 ± 12 | 49 ± 11 | 52 ± 13 | 51 ± 13 | 0.005 | 0.005 | 0.131 | 0.309 |
Low-density lipoprotein (mg/dL) | 121 ± 36 | 121 ± 36 | 123 ± 39 | 119 ± 34 | 0.472 | 0.786 | 0.730 | 0.452 |
High-sensitivity CRP (mg/L) | 0.15 ± 0.36 | 0.15 ± 0.34 | 0.14 ± 0.28 | 0.17 ± 0.42 | 0.531 | 0.959 | 0.617 | 0.597 |
Organ damage assessment | ||||||||
Coronary calcium score | 40 ± 144 | 44 ± 155 | 13 ± 48 | 50 ± 159 | 0.016 | 0.039 | 0.890 | 0.015 |
Ankle-brachial PWV (cm/s) | 1429 ± 259 | 1448 ± 284 | 1340 ± 190 | 1447 ± 245 | 0.001 | 0.001 | 1.000 | 0.002 |
Carotid intima-media thickness (mm) | 0.63 ± 0.13 | 0.64 ± 0.14 | 0.59 ± 0.11 | 0.63 ± 0.13 | 0.030 | 0.022 | 0.668 | 0.125 |
Fatty liver on ultrasound, n (%) | 502 (50) | 245 (50) | 73 (41) | 184 (54) | 0.018 | 0.042 | 0.255 | 0.005 |