Skip to main content

Table 3 Mortality before and after OPV and VAS campaigns, Stratified by age at measles vaccination and sex

From: Is early measles vaccination associated with stronger survival benefits than later measles vaccination?

  OPV campaign VAS campaign
  Before After Before After
All children (number of observations) 31,725 13,936 31,725 11,950
  MR per 1000 PYRS deaths/ PYRS) HR (95% CI)a MR per 1000 PYRS deaths/ PYRS) HR (95% CI)a MR per 1000 PYRS (deaths/ PYRS) HR (95% CI)a MR per 1000 PYRS (deaths/ PYRS) HR (95% CI)a
Measles unvaccinated 73.2 (215/2938) 1 (ref) 46.8 (57/1217) 1 (ref) 72.2 (231/3199) 1 (ref) 42.9 (41/956) 1 (ref)
Measles vaccinated 47.2 (345/7314) 0.74 (0.60–0.92) 38.5 (96/2496) 0.85 (0.56–1.27) 47.3 (371/7840) 0.76 (0.61–0.93) 35.5 (70/1971) 0.71 (0.42–1.18)
 Early age (< 274 days)b 45.7 (86/1883) 0.70 (0.53–0.92) 31.0 (20/645) 0.63 (0.36–1.12) 44.0 (90/2047) 0.68 (0.52–0.89) 33.3 (16/481) 0.69 (0.35–1.35)
 Recommended age (274–365 days)b 43.2 (135/3124) 0.71 (0.55–0.92) 47.2 (53/1122) 1.07 (0.68–1.69) 45.5 (151/3319) 0.76 (0.60–0.97) 39.9 (37/926) 0.78 (0.45–1.36)
 Late (366–735 days)b 53.7 (124/2308) 0.89 (0.67–1.18) 31.5 (23/730) 0.70 (0.39–1.25) 52.5 (130/2474) 0.88 (0.67–1.16) 30.1 (17/564) 0.57 (0.28–1.15)
Boys (number of observations) 16,127 7104 16,127 6107
Measles unvaccinated 71.9 (107/1488) 1 (ref) 43.9 (27/616) 1 (ref) 70.5 (115/1632) 1 (ref) 40.3 (19/472) 1 (ref)
Measles vaccinated 47.5 (177/3725) 0.75 (0.57–0.99) 42.5 (54/1270) 0.97 (0.58–1.64) 49.6 (198/3993) 0.80 (0.61–1.04) 32.9 (33/1002) 0.73 (0.37–1.41)
 Early age (< 274 days)b 49.1 (47/957) 0.76 (0.53–1.09) 45.1 (15/333) 0.93 (0.47–1.84) 49.8 (52/1045) 0.78 (0.55–1.10) 40.9 (10/245) 0.90 (0.39–2.09)
 Recommended age (274–365 days)b 42.4 (68/1605) 0.69 (0.50–0.97) 44.2 (25/566) 1.08 (0.58–1.98) 45.8 (78/1702) 0.77 (0.56–1.05) 32.0 (15/469) 0.69 (0.32–1.51)
 Late (366–735 days)b 53.3 (62/1164) 0.88 (0.61–1.26) 37.8 (14/371) 0.84 (0.41–1.75) 54.6 (68/1246) 0.92 (0.65–1.31) 27.7 (8/289) 0.57 (0.22–1.46)
Girls (number of observations) 15,598 6832 15,598 5843
Measles unvaccinated 74.5 (108/1450) 1 (ref) 49.9 (30/601) 1 (ref) 74.0 (116/1567) 1 (ref) 45.4 (22/484) 1 (ref)
Measles vaccinated 46.8 (168/3589) 0.74 (0.56–0.97) 34.2 (42/1227) 0.72 (0.42–1.24) 45.0 (173/3847) 0.71 (0.54–0.93) 38.2 (37/969) 0.69 (0.36–1.31)
 Early age (< 274 days)b 42.1 (39/926) 0.63 (0.43–0.93) 16.0 (5/312) 0.32 (0.12–0.86) 37.9 (38/1002) 0.58 (0.39–0.85) 25.4 (6/236) 0.48 (0.18–1.29)
 Recommended age (274–365 days)b 44.1 (67/1519) 0.73 (0.52–1.02) 50.4 (28/556) 1.06 (0.59–1.90) 45.1 (73/1617) 0.75 (0.54–1.04) 48.1 (22/458) 0.83 (0.41–1.67)
 Late (366–735 days)b 54.2 (62/1144) 0.90 (0.63–1.29) 25.1 (9/359) 0.54 (0.23–1.24) 50.5 (62/1228) 0.83 (0.59–1.19) 32.7 (9/275) 0.56 (0.22–1.40)
  1. aAge as underlying time scale, stratified by village cluster; bAge at measles vaccination according to the information obtained from the vaccination card at the beginning of the observation period
  2. Abbreviations: MR Mortality Rate, PYRS Person years, HR Hazard Ratio, CI Confidence interval