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Table 2 Univariable longitudinal analysis (using GEE) of sexual risk behavior factors among sexually active participants

From: Changes in (risk) behavior and HPV knowledge among Dutch girls eligible for HPV vaccination: an observational cohort study

  Round 1a Round 2 Round 3 Round 4 Round 5    
Category n (%) n (%) n (%) n (%) n (%) p-value OR (+ 95% CI) aORc (+ 95% CI)
Having had sex for the first time during previous 6 months
 Unvaccinated 84 (22) 71 (20) 69 (18) 59 (17) 0.01 Ref Ref
 Vaccinated 216 (26) 166 (20) 170 (19) 179 (21) < 0.01 1.15 (0.97–1.37) 1.14 (0.96–1.35)
Lifetime number of sexual partnersb (mean 95%CI)
 Unvaccinated 2.2 (2.0–2.4) 2.5 (2.3–2.7) 2.7 (2.4–3.0) 3.0 (2.7–3.3) 3.4 (3.1–3.8) < 0.01 Ref Ref
 Vaccinated 1.9 (1.8–2.0) 2.1 (2.0–2.3) 2.4 (2.3–2.6) 2.9 (2.7–3.1) 3.0 (2.8–3.2) < 0.01 − 0.20 (− 0.41–0.00)b −0.26 (− 0.46 – -0.05)
Having a steady partner at the moment
 Unvaccinated 349 (67) 275 (71) 247 (68) 275 (72) 250 (72) 0.17 Ref Ref
 Vaccinated 729 (68) 586 (69) 576 (68) 622 (68) 578 (69) 0.34 0.96 (0.82–1.13) 1.02 (0.87–1.19)
Having had a casual partner during previous 6 months
 Unvaccinated 271 (52) 96 (25) 77 (21) 82 (22) 81 (23) < 0.01 Ref Ref
 Vaccinated 512 (48) 163 (19) 170 (20) 234 (26) 189 (23) < 0.01 0.92 (0.80–1.06) 1.11 (0.96–1.29)
  1. The p-value indicates whether there is a significant change over time. The OR indicates possible differences between vaccinated and unvaccinated participants overall (across all five time points)
  2. - Not asked in this round (Having had sex for the first time during previous 6 months was only questioned from round two onward)
  3. aPreviously published by Mollers et al. [17]
  4. bFor continuous variables, the mean difference was calculated. For other variables, odds ratios were calculated
  5. cOR was adjusted for degree of urbanization and alcohol use