S/N | Author: Year | Country: Setting | Study Design | Participants/overall sample size | Type of PMTCT intervention implemented | QAR of studies |
---|---|---|---|---|---|---|
1 | Meda, et al. 2002 [64] | Cote’d Ivoire and Burkina Faso Urban in both countries. | Randomised clinical trial | HIV+ pregnant women enrolled in an open label cohort at 36–38 weeks gestation to receiving an oral course of zidovudine. (404) | ZDV | ** |
2 | *Kiarie, et al. 2003 [30] | Kenya: Urban | Randomised clinical trial | HIV+ pregnant women enrolled in a clinical trial in a tertiary HF. (124) | ZDV,SdNVP | **** |
3 | Stringer, et al. 2003 [37] | Zambia: Urban | Clustered-randomised clinical trial | HIV+ pregnant women attending two HF in the trial. (201) | SdNVP | ** |
4 | Farquhar, et al. 2004 [54] | Kenya: Urban | Prospective cohort study | Pregnant women attending one clinic; male partners.(1991) | SdNVP | **** |
5 | Banda, et al. 2007 [47] | Zambia: Urban | Clinical trial: sub-analysis | HIV + pregnant women enrolled in a clinical trial of perinatal HIV prevention strategies at two district delivery centres.(78) | SdNVP | * |
6 | Coffie,et al. 2008 [69] | Ivory Cost: Urban | Prospective cohort study | HIV + women pregnant registered in a PMTCT plus programme. (247) | cART (ZDV + 3TC + NVP) (94.7%): (D4T + 3TC + NVP) (2.8%): (ZDV + 3TC + EFV (2.1%): (D4T + 3TC + EFV) (0.4%). | *** |
7 | Msuya, et al. 2008 [53] | Tanzania: Urban | Prospective cohort study | HIV+ pregnant women attending ANC at two public clinics for PMTCT services; with/without male partner support. (184) | SdNVP | **** |
8 | Peltzer, et al. 2008 [52] | South Africa: Unclear | Cross sectional study | HIV+ pregnant women in a PMTCT cohort from five clinics (66). | SdNVP | **** |
9 | Delvaux, et al. 2009 [29] | Rwanda: Urban and rural | Case-control study | HIV + pregnant women who did not adhere (cases) and adhered (control) to PMTCT prophylaxis at 12 PMTCT sites. (236) | SdNVP | **** |
10 | Megazzini, et al. 2009 [58] | Zambia: Urban | Clustered randomised clinical trial: sub-analysis | Pregnant women in the trial intervention arm who had HCT in the labour ward.(23) | SdNVP | * |
11 | *Bancheno, et al. 2010 [28] | Swaziland: Rural | Retrospective cohort study | HIV + pregnant women registered for PMTCT services in a rural HF. (99) | SdNVP | * |
12 | Barigye, et al. 2010 [57] | Uganda: Rural | Prospective cohort study | HIV + pregnant women registered for PMTCT services at four clinics located in study and non-study villages. (83) | SdNVP | **** |
13 | Igwegbe, et al. 2010 [34] | Nigeria: Urban | Cross sectional study | HIV+ pregnant women attending PMTCT clinic in a tertiary HF.(368) | cART (specific ARV drugs combination NR). | *** |
14 | Kuonza, et al. 2010 [36] | Zimbabwe: Urban | Cross sectional study | HIV + pregnant women and their infants registered in PMTCT programme in four HF. (212) | SdNVP | *** |
15 | Megazzini, et al. 2010 [65] | Zambia: Urban | Clustered randomised clinical trial: | HIV + pregnant women receiving PMTCT services in 12 public delivery centres. (498) | SdNVP | * |
16 | Peltzer, et al. 2010 [27] | South Africa: Rural | Cross sectional study | HIV + pregnant women and their infants at 47 HFs. (815) | SdNVP | *** |
17 | Shapiro, et al. 2010 [66] | Botswana: Urban and rural | Randomised control trial | HIV + pregnant women enrolled into the trial at four HFs.(730) | cART (ABC + AZT + 3TC): Lopinarvir-ritonavir+AZT + 3TC): (NVP + AZT + 3TC). | ** |
18 | El-Khatib,et al. 2011 [35] | South Africa: Urban | Prospective cohort study | HIV + women pregnant registered in an ART programme in a single HF. (147) | cART (D4T + 3TC + NVor EFV). | *** |
19 | Kinuthia, et al. 2011 [26] | Kenya: Urban | Cross sectional study | Sub set of HIV+ women and their infants attending six MCH clinics.(318) | Short course AZT regimen, sdNVP. | **** |
20 | Kirsten, et al. 2011 [25] | Tanzania: Rural | Prospective cohort study | HIV + women pregnant registered in a single HF offering PMTCT services. (150) | AZT and cART (AZT + 3TC). | **** |
21 | *Mepham, et al. 2011 [38]. | South Africa: Rural | Randomised control trial | HIV + pregnant women receiving PMTCT services in a HF. (94) | cART(specific ARV drugs combination NR). | * |
22 | Mirkuzie, et al. 2011 [24] | Ethiopia: Urban | Prospective cohort study | HIV + pregnant women attending 15 HF and their infants.(282) | cART and ZDV prophylaxis. | *** |
23 | Parisotto, et al. 2011 [33] | Burkina Faso: Urban | Retrospective cohort study | HIV + pregnant women and their children at one HF.(229) | Short course ARV prophylaxis: Actual ARV drug(s) NR. | **** |
24 | Peltzer, et al. 2011 [50] | South Africa: Rural | Cross sectional study | HIV + pregnant and postnatal women and their infants recruited from 48 HFs.(746) | AZT | **** |
25 | Ekama, et al. 2012 [31] | Nigeria: Urban | Cross sectional study | HIV+ pregnant women registered for PMTCT services at ART treatment centre.(170) | cART (specific ARV drugs combination NR). | ** |
26 | Okonji, et al.2012 [67] | Kenya: Urban | Clinical trial: sub-analysis | HIV + women pregnant enrolled into the trial at a single HF rendering combination ART for PMTCT.(434) | cART (NVP + 3TC + ZDV, NFV + 3TC + ZDV). | ** |
27 | Bisio, et al. 2013 [75] | Republic of Congo: Urban and rural. | Prospective uncontrolled interventional study | HIV + women pregnant attending four Antenatal clinics.(415) | cART(AZT + 3TC + NVP, D4T + 3TC + NVP) | *** |
28 | Denoeud-Ndam, et al. 2013 [70] | Benin: Urban | Prospective cohort study | HIV + women pregnant at 5 hospitals attending ANC. (217) | cART (EFV/NVP/PI). | *** |
29 | Buseri, et al. 2014 [23] | Nigeria: Urban and rural. | Cross sectional study | HIV + pregnant women receiving PMTCT services at ANC in four hospitals. (312) | cART (AZT or D4T + 3TC + NVPor EFV). | ** |
30 | Kamuyango et al. 2014 [77] | Malawi: Urban and rural | Retrospective cohort study | HIV + women in ART sites who received ARV intervention for PMTCT.(292) | cART (D4T + 3TC + NVP: TDF + 3TC + EFV). | **** |
31 | *Murithi, et al. 2015 [41] | Kenya: Urban | Cross sectional study | HIV + women pregnant receiving care in a PMTCT clinic.(55) | cART(specific ARV drugs combination NR). | ** |
32 | Ebuy, et al. 2015 [48] | Ethiopia: Urban and rural | Cross sectional study | HIV + women pregnant registered for PMTCT in six hospitals. (263) | cART (EFV + 3TC + TDF). | **** |
33 | Itoua,et al. 2015 [46] | Republic of Congo: Urban | Cross analytical and transversal study | HIV + women pregnant and lactating enrolled in three treatment centres. (80) | cART (specific ARV drugs combination NR). | ** |
34 | Ngoma, et al. 2015 [71] | Zambia: Urban | Prospective cohort study | HIV + pregnant women with the ability to initiate combination ART AT 14–30 weeks at a public HF. (226) | cART (AZT + 3TC + Lopinavir/ ritonavir). | *** |
35 | Okawa, et al.2015 [22] | Zambia: Rural | Prospective cohort study | HIV + pregnant women registered in PMTCT service at eleven HFs. (481) | AZT, sdNVP, and cART (specific ARV drugs NR). | *** |
36 | *Granato, et al. 2016 [78] | Cote d’ Ivoire: Urban and Rural. | Cross sectional study | HIV positive pregnant women enrolled in PMTCT services attending 29 HFs. (219) | cART (specific ARV drugs combination NR). | **** |
37 | Haas, et al. 2016 [32] | Malawi: Urban and rural. | Retrospective cohort study | HIV + women pregnant and postpartum women who commenced ART regimen at 13 HFs. (4248) | cART(EFV + 3TC + TDF | **** |
38 | Hampanda 2016 [21] | Zambia: Urban | Cross sectional study | HIV + postpartum women and their infants at a large HF attending child immunization.(402) | SdNVP and cART (specific ARV drugs combination NR). | **** |
39 | Matthews, et al. 2016 [76] | Uganda: Rural | Prospective cohort study | HIV + pregnant women; a subset of more than 7000 HIV infected adults initiating their ART in a tertiary HF.(396) | cART (specific ARV drugs combination NR). | **** |
40 | *Napua, et al. 2016 [40] | Mozambique: Urban | Clustered(facility level) randomised controlled trial | HIV + women pregnant registered in 6 high volume HFs providing PMTCT and ART services. (141) | cART (specific ARV drugs combination NR). | * |
41 | Schnack, et al. 2016 [10] | Uganda: Urban. | Observational longitudinal study. | HIV + pregnant women attending ANC in two hospitals with PMTCT programme. (76) | cART (specific ARV drugs combination NR). | ** |
42 | Yotebieng, et al. 2016 [20] | DRC Congo: Urban. | Randomised clinical trial | Newly diagnosed HIV + pregnant women registering for ANC at 89 HFs. (300) | AZT, and cART (specific ARV drugs combination NR). | * |