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Table 1 Themes of adherence to medication among HIV positive pregnant women included in qualitative studies (N = 15)

From: Medication adherence in pregnant women with human immunodeficiency virus receiving antiretroviral therapy in sub-Saharan Africa: a systematic review

Domain

Themes

References (study numbers)

Patient

Psychological

 

Shock/denial following a positive HIV result

[1, 6, 9, 14]

Motivation to protect infant/self/family

[6, 9, 10]

Patient knowledge on ART/PMTCT

 

Poor knowledge of ART, MTCT

[4]

Good knowledge of ART

[3]

Self-efficacy

 

Self-reported ability to adhere to ART

[6, 8]

Patient attitude and personal management

 

Late ANC attendance an obstacle to early AZT prophylaxis and initiation on HAART

[2]

Missing clinical appointments

[1]

Interrupted personal routine

[4]

Patient belief system

 

Religious belief

[13]

Use of traditional medicines

[5]

Patient condition

Disease progression

[13]

Obstetric/ pregnancy

 

Uncertainty about onset of labour in order to swallow NVP

[1]

Previous experience with PMTCT

[9]

Therapy

Side effects of ART

[6, 13]

Perceived effectiveness of therapy

[6, 9]

Social and economic factors

Financial difficulty

 

Lack of transport fee to go to health facility for pick-up of ARVs

[1, 2, 3, 13]

Lack of money to buy food to eat

[3, 4, 13]

Women empowerment

 

Economically dependent on husbands

[3]

Domestic violence either actual or threatened

[4]

Lack of male involvement

[2]

Cultural conditions and beliefs

 

Traditional medicines/healers

[4, 5]

Religious beliefs

[13]

Partner and community – the challenges of disclosure and non-disclosure

 

Fear of disclosure to partner/family members

[3, 4, 5, 8, 9, 10, 13, 14]

Disclosure to partner/family(facilitating)

[8, 13]

HIV infected relatives stealing tablets

[4]

Hiding ARVS within the house/taking ARVs in hiding in the house

[4, 5]

Pattern of misinformation on ART in the community

[14]

HIV related stigma

[2, 5, 9, 10, 13, 15]

Community view of HIV- infected persons had no bearing on their decision to begin or continue ART

[3]

Sharing medication with others

 

Sharing ARVs with partner/friend

[1, 4]

Positive outlook of known patients living with HIV in the community

 

Seeing positive results in the community of women taking ART and looking healthy

[9, 10, 12]

Health care team/health system

Staff related

 

Fear of mistreatment by HCWs

[1, 3, 7, 10]

HCWs providing good counselling on ART

[6, 7, 8]

Supply chain management system

 

Delayed supply of ARVs

[2, 6, 7]

Resource/Infrastructure and service related

 

Prolonged counselling to initiate prophylaxis or ART

[2, 3]

Lack of privacy and confidentiality

[2, 7]

Inadequate counselling and short contact time with patient

[2]

Long waiting time in the health facilities

[3, 11]

  1. ANC Antenatal clinic, HCWs Health care workers, ARV Antiretroviral, ART Antiretroviral therapy, MTCT Mother to child transmission of HIV, NVP Nevirapine, AZT Zidovudine. Study numbers = the order in which the references appear on Table 4