Table 2 Results from the three regressions applied, segmented multiple linear regression model, for the proportion of HBP patients, and both multiples linear regressions using standard methods for interrupted time series, for the ACS and stroke outcomes

  Pre-breakpoint trend (change per month)

0.004 (0.003;0.006)

–

–

  Change in trend (post-breakpoint vs pre-breakpoint)

−0.006

–

< 0.001

  Post-breakpoint trend (change per month)

−0.002 (− 0.003;-0.001)

–

–

  Pre-breakpoint trend (change per month)

− 0.003(− 0.022;0.022)

–

–

  Change in trend (post-breakpoint vs pre-breakpoint)

− 0.016

–

0.215

  Post-breakpoint trend (change per month)

−0.019(− 0.061;0.023)

–

–

  Pre-breakpoint trend (change per month)

−0.003(− 0.028;0.022)

–

–

  Change in trend (post-breakpoint vs pre-breakpoint)

− 0.016

–

0.215

  Post-breakpoint trend (change per month)

−0.018(− 0.052;0.014)

–

–

  Pre-breakpoint trend (change per month)

−0.022(− 0.798;0.754)

–

–

  Change in trend (post-breakpoint vs pre-breakpoint)

0.011

–

> 0.05

  Post-breakpoint trend (change per month)

−0.011(− 0.039;0.017)

–

–

  Pre-breakpoint trend (change per month)

0.029(−0.017;0.075)

–

–

  Change in trend (post-breakpoint vs pre-breakpoint)

−0.018

–

> 0.05

  Post-breakpoint trend (change per month)

0.011(−0.017;0.039)

–

–

  Time of the breakpoint

−0.112(− 2.041;1.817)

−0.114

0.909

  Time of the breakpoint^a time interaction

−0.031(− 0.09;0.036)

−0.903

0.368

  Time of the breakpoint

0.289(− 2.269;2.848)

0.222

0.825

  Time of the breakpoint^a time interaction

−0.018(− 0.108;0.072)

−0.393

0.695

  Time of the breakpoint

−0.497(− 1.927;0.932)

−0.682

0.496

  Time of the breakpoint^a time interaction

0.013(−0.034;0.060)

0.560

0.576

  Time of the breakpoint

0.151(−0.723;1.024)

0.338

0.736

  Time of the breakpoint^a time interaction

−0.015(− 0.044;0.015)

−0.986

0.325

  Time of the breakpoint

0.151(− 5.159;6.721)

0.258

0.7970

  Time of the breakpoint^a time interaction

−0.015(− 0.358;0.066)

−1.349

0.1792

  Time of the breakpoint

0.265(−1.399;1.929)

0.312

0.755

  Time of the breakpoint^a time interaction

−0.037(− 0.091;0.016)

−1.370

0.172

  Time of the breakpoint

0.900(−0.743;2.543)

1.074

0.284

  Time of the breakpoint^a time interaction

−0.022(− 0.074;0.030)

−0.822

0.412

  Time of the breakpoint

0.999(−1.204;3.202)

0.888

0.376

  Time of the breakpoint^a time interaction

−0.047(− 0.121;0.027)

−1.244

0.215

  Time of the breakpoint

0.448(−0.261;1.157)

1.238

0.217

  Time of the breakpoint^a time interaction

−0.014(− 0.037;0.009)

−1.207

0.229

  Time of the breakpoint

2.548(− 5.351;10.446)

0.632

0.528

  Time of the breakpoint^a time interaction

−0.238(− 0.502;0.026)

−1.764

0.079