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Table 4 Joint-effects of BMI and other central obesity measures on the hazard of type 2 diabetes in men, TLGS study

From: Optimal cut-points of different anthropometric indices and their joint effect in prediction of type 2 diabetes: results of a cohort study

  Incident T2D /total participants Univariate model Model 1a Model 2b
(%) HR (95% CI) P Value HR (95% CI) P-value HR (95% CI) P-value
BMI (kg/m2)-WC(cm)
  < 25.56- < 89 70/1302 (5.38) Reference Reference Reference
  ≥ 25.56- < 89 24/191 (12.57) 2.23(1.40–3.56) 0.001 1.75(1.10–2.80) 0.018 1.83(1.14–2.95) 0.012
  < 25.56- ≥ 89 19/184 (10.33) 1.54(0.93–2.57) 0.093 1.04(0.62–1.74) 0.879 1.07(0.64–1.81) 0.778
  ≥ 25.56- ≥ 89 241/1311 (18.38) 3.13(2.39–4.09) < 0.001 2.21(1.67–2.91) < 0.001 2.38(1.75–3.25) < 0.001
BMI (kg/m2)- WHtR
  < 25.56- < 0.52 73/1311 (5.57) Reference Reference Reference
  ≥ 25.56- < 0.52 24/202 (11.88) 2.09(1.32–3.32) 0.002 1.73(1.08–2.75) 0.020 1.81(1.13–2.92) 0.014
  < 25.56- ≥ 0.52 16/175 (9.14) 1.18(0.68–2.04) 0.549 0.80(0.46–1.40) 0.444 0.80(0.46–1.39) 0.437
  ≥ 25.56- ≥ 0.52 241/1300 (18.54) 2.98(2.28–3.88) < 0.001 2.08(1.58–2.74) < 0.001 2.20(1.64–2.97) < 0.001
BMI (kg/m2)- WHR
  < 25.56- < 0.91 48/1116 (4.3) Reference Reference Reference
  ≥ 25.56- < 0.91 44/354 (12.43) 2.89(1.92–4.36) < 0.001 2.08(1.37–3.15) 0.001 2.20(1.43–3.38) < 0.001
  < 25.56- ≥ 0.91 41/370 (11.08) 2.05(1.34–3.13) 0.001 1.54(1.00–2.36) 0.047 1.55(1.01–2.38) 0.044
  ≥ 25.56- ≥ 0.91 221/1148 (11.85) 3.87(2.82–5.31) < 0.001 2.70(1.95–3.74) < 0.001 2.88(2.03–4.08) < 0.001
BMI (kg/m2)- HC
  < 25.56- < 96 68/1147 (5.93) Reference Reference Reference
  ≥ 25.56- < 96 23/158 (14.56) 1.98(1.23–3.18) 0.005 1.35(0.83–2.19) 0.224 1.41(0.86–2.30) 0.164
  < 25.56- ≥ 96 21/339 (6.19) 1.03(0.63–1.69) 0.881 0.86(0.52–1.41) 0.564 0.92(0.55–1.51) 0.774
  ≥ 25.56- ≥ 96 242/1344 (18.01) 2.92(2.23–3.83) < 0.001 2.15(1.63–2.84) < 0.001 2.40(1.75–3.30) < 0.001
  1. aAdjusted for age (in time-scale manner), education level, family history of type 2 diabetes, systolic blood pressure, fasting plasma glucose, and triglyceride to high-density lipoprotein cholesterol ratio
  2. bAdjusted for model 1 variables and wrist circumference
  3. HR hazard ratio, CI confidence interval, BMI body mass index, WC waist circumference, WHtR waist to height ratio, WHR waist to hip ratio, HC hip circumference