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Table 3 Results of two multivariable generalized ordered logit modelsa with partial proportional odds which examine associations between patient characteristics and the completionb of daily-dose isoniazid treatment for latent tuberculosis infection (N = 1072)

From: Predictors of latent tuberculosis infection treatment completion in the US private sector: an analysis of administrative claims data

   Model 1: Includes Count of Clinical Risk Factors Model 2: Includes Specific Clinical Risk Factors
Independent Variables Adjusted Odds Ratio 95% Confidence Interval p-value Adjusted Odds Ratio 95% Confidence Interval p-value
Sex Female 1.000     1.000    
Male 1.085 0.855 1.378 0.501 1.045 0.818 1.335 0.724
Age Group 0–14 1.000     1.000    
15–29 0.547 0.351 0.854 0.008 0.552 0.353 0.863 0.009
30–44 0.597 0.385 0.925 0.021 0.599 0.386 0.930 0.022
45–64 0.584 0.370 0.920 0.020 0.574 0.362 0.909 0.018
Census Region Northeast 1.000     1.000    
Midwest 0.934 0.588 1.483 0.772 0.933 0.587 1.484 0.771
South 0.716 0.466 1.102 0.129 0.692 0.449 1.069 0.097
West 0.989 0.676 1.448 0.956 0.967 0.661 1.416 0.864
Patient Location Neither regimen completed vs. ≥6 months completed (completed 6 or 9 month regimen)
Large central metro county 1.000     1.000    
Large fringe metro county 0.600 0.414 0.868 0.007 0.592 0.408 0.858 0.006
Any smaller county 0.767 0.495 1.189 0.235 0.776 0.500 1.203 0.256
< 9 months completed (neither regimen or 6 month regimen completed) vs. ≥9 months completed
Large central metro county 1.000     1.000    
Large fringe metro county 0.800 0.537 1.193 0.275 0.791 0.530 1.182 0.253
Any smaller county 0.767 0.495 1.189 0.235 0.776 0.500 1.203 0.256
% of Households Under FPL in County < 15% 1.000     1.000    
≥15% 0.628 0.469 0.841 0.002 0.609 0.454 0.817 0.001
Insurance Type Neither regimen completed vs. ≥6 months completed (completed 6 or 9 month regimen)
HMO 1.000     1.000    
POS 1.434 0.981 2.097 0.063 1.513 1.032 2.218 0.034
PPO 1.817 1.147 2.878 0.011 1.864 1.174 2.961 0.008
< 9 months completed (neither regimen or 6 month regimen completed) vs. ≥9 months completed
HMO 1.000     1.000    
POS 1.434 0.981 2.097 0.063 1.513 1.032 2.218 0.034
PPO 2.840 1.745 4.622 < 0.001 2.921 1.789 4.767 < 0.001
Prescription Size Neither regimen completed vs. ≥6 months completed (completed 6 or 9 month regimen)
< 2 month supply 1.000     1.000    
≥2 month supply 1.419 0.884 2.278 0.148 1.395 0.867 2.245 0.170
< 9 months completed (neither regimen or 6 month regimen completed) vs. ≥9 months completed
< 2 month supply 1.000     1.000    
≥2 month supply 2.268 1.383 3.720 0.001 2.233 1.359 3.670 0.002
Year INH Regimen Started 2011 Q3–4 1.000     1.000    
2012 Q1–4 1.109 0.802 1.532 0.531 1.104 0.798 1.526 0.551
2013 Q1–4 1.268 0.906 1.774 0.167 1.261 0.901 1.766 0.177
2014 Q1 1.333 0.720 2.468 0.361 1.333 0.718 2.473 0.363
State TB Rate 0.905 0.793 1.033 0.138 0.913 0.800 1.042 0.178
LTBI Diagnostic Test TST 1.000     1.000    
IGRA 1.255 0.897 1.757 0.185 1.171 0.829 1.653 0.371
Unknown/Other 0.813 0.616 1.071 0.141 0.812 0.615 1.071 0.141
Percent Foreign Born in County 1.004 0.989 1.019 0.612 1.004 0.989 1.019 0.636
Count of Clinical Risk Factors None 1.000        
1 1.522 1.158 2.001 0.003 na na na na
2 or more 1.816 1.188 2.778 0.006 na na na na
Diagnosis of Contact w/ TB No diagnosis na na na na 1.000    
Had diagnosis na na na na 1.289 0.916 1.814 0.145
History of TB/Late Effects No diagnosis na na na na 1.000    
Had diagnosis na na na na 1.152 0.655 2.027 0.624
HIV Positive No diagnosis na na na na 1.000    
Had diagnosis na na na na 2.578 1.377 4.827 0.003
Diabetes No diagnosis or medication na na na na 1.000    
Had diagnosis or medication na na na na 1.458 0.902 2.355 0.124
Tobacco No diagnosis or medication na na na na 1.000    
Had diagnosis or medication na na na na 1.254 0.766 2.052 0.368
Immuno-suppressive Medications No medication na na na na 1.000    
Had medication na na na na 1.470 0.997 2.167 0.052
  1. aConstraints for parallel lines were applied to all independent variables except patient location, insurance type, and isoniazid days supply received
  2. bFor both models, isoniazid treatment completion was categorized as 1) less than 6 months completed, 2) at least 6 months but less than 9 months completed, and 3) 9 or more months completed
  3. Abbreviations: INH isoniazid, FPL federal poverty level, TB tuberculosis, TST tuberculin skin test, IGRA interferon-gamma release assays, LTBI latent tuberculosis infection, HMO health maintenance organization, POS point of service, PPO preferred provider organization