Predictors of latent tuberculosis infection treatment completion in the US private sector: an analysis of administrative claims data

Stockbridge, Erica L.; Miller, Thaddeus L.; Carlson, Erin K.; Ho, Christine

doi:10.1186/s12889-018-5578-3

Table 3 Results of two multivariable generalized ordered logit models^a with partial proportional odds which examine associations between patient characteristics and the completion^b of daily-dose isoniazid treatment for latent tuberculosis infection (N = 1072)

From: Predictors of latent tuberculosis infection treatment completion in the US private sector: an analysis of administrative claims data

		Model 1: Includes Count of Clinical Risk Factors				Model 2: Includes Specific Clinical Risk Factors
Independent Variables		Adjusted Odds Ratio	95% Confidence Interval		p-value	Adjusted Odds Ratio	95% Confidence Interval		p-value
Sex	Female	1.000				1.000
Sex	Male	1.085	0.855	1.378	0.501	1.045	0.818	1.335	0.724
Age Group	0–14	1.000				1.000
	15–29	0.547	0.351	0.854	0.008	0.552	0.353	0.863	0.009
	30–44	0.597	0.385	0.925	0.021	0.599	0.386	0.930	0.022
	45–64	0.584	0.370	0.920	0.020	0.574	0.362	0.909	0.018
Census Region	Northeast	1.000				1.000
	Midwest	0.934	0.588	1.483	0.772	0.933	0.587	1.484	0.771
	South	0.716	0.466	1.102	0.129	0.692	0.449	1.069	0.097
	West	0.989	0.676	1.448	0.956	0.967	0.661	1.416	0.864
Patient Location	Neither regimen completed vs. ≥6 months completed (completed 6 or 9 month regimen)
	Large central metro county	1.000				1.000
	Large fringe metro county	0.600	0.414	0.868	0.007	0.592	0.408	0.858	0.006
	Any smaller county	0.767	0.495	1.189	0.235	0.776	0.500	1.203	0.256
	< 9 months completed (neither regimen or 6 month regimen completed) vs. ≥9 months completed
	Large central metro county	1.000				1.000
	Large fringe metro county	0.800	0.537	1.193	0.275	0.791	0.530	1.182	0.253
	Any smaller county	0.767	0.495	1.189	0.235	0.776	0.500	1.203	0.256
% of Households Under FPL in County	< 15%	1.000				1.000
% of Households Under FPL in County	≥15%	0.628	0.469	0.841	0.002	0.609	0.454	0.817	0.001
Insurance Type	Neither regimen completed vs. ≥6 months completed (completed 6 or 9 month regimen)
	HMO	1.000				1.000
	POS	1.434	0.981	2.097	0.063	1.513	1.032	2.218	0.034
	PPO	1.817	1.147	2.878	0.011	1.864	1.174	2.961	0.008
	< 9 months completed (neither regimen or 6 month regimen completed) vs. ≥9 months completed
	HMO	1.000				1.000
	POS	1.434	0.981	2.097	0.063	1.513	1.032	2.218	0.034
	PPO	2.840	1.745	4.622	< 0.001	2.921	1.789	4.767	< 0.001
Prescription Size	Neither regimen completed vs. ≥6 months completed (completed 6 or 9 month regimen)
	< 2 month supply	1.000				1.000
	≥2 month supply	1.419	0.884	2.278	0.148	1.395	0.867	2.245	0.170
	< 9 months completed (neither regimen or 6 month regimen completed) vs. ≥9 months completed
	< 2 month supply	1.000				1.000
	≥2 month supply	2.268	1.383	3.720	0.001	2.233	1.359	3.670	0.002
Year INH Regimen Started	2011 Q3–4	1.000				1.000
	2012 Q1–4	1.109	0.802	1.532	0.531	1.104	0.798	1.526	0.551
	2013 Q1–4	1.268	0.906	1.774	0.167	1.261	0.901	1.766	0.177
	2014 Q1	1.333	0.720	2.468	0.361	1.333	0.718	2.473	0.363
State TB Rate		0.905	0.793	1.033	0.138	0.913	0.800	1.042	0.178
LTBI Diagnostic Test	TST	1.000				1.000
	IGRA	1.255	0.897	1.757	0.185	1.171	0.829	1.653	0.371
	Unknown/Other	0.813	0.616	1.071	0.141	0.812	0.615	1.071	0.141
Percent Foreign Born in County		1.004	0.989	1.019	0.612	1.004	0.989	1.019	0.636
Count of Clinical Risk Factors	None	1.000
	1	1.522	1.158	2.001	0.003	na	na	na	na
	2 or more	1.816	1.188	2.778	0.006	na	na	na	na
Diagnosis of Contact w/ TB	No diagnosis	na	na	na	na	1.000
Diagnosis of Contact w/ TB	Had diagnosis	na	na	na	na	1.289	0.916	1.814	0.145
History of TB/Late Effects	No diagnosis	na	na	na	na	1.000
History of TB/Late Effects	Had diagnosis	na	na	na	na	1.152	0.655	2.027	0.624
HIV Positive	No diagnosis	na	na	na	na	1.000
HIV Positive	Had diagnosis	na	na	na	na	2.578	1.377	4.827	0.003
Diabetes	No diagnosis or medication	na	na	na	na	1.000
Diabetes	Had diagnosis or medication	na	na	na	na	1.458	0.902	2.355	0.124
Tobacco	No diagnosis or medication	na	na	na	na	1.000
Tobacco	Had diagnosis or medication	na	na	na	na	1.254	0.766	2.052	0.368
Immuno-suppressive Medications	No medication	na	na	na	na	1.000
Immuno-suppressive Medications	Had medication	na	na	na	na	1.470	0.997	2.167	0.052

^aConstraints for parallel lines were applied to all independent variables except patient location, insurance type, and isoniazid days supply received
^bFor both models, isoniazid treatment completion was categorized as 1) less than 6 months completed, 2) at least 6 months but less than 9 months completed, and 3) 9 or more months completed
Abbreviations: INH isoniazid, FPL federal poverty level, TB tuberculosis, TST tuberculin skin test, IGRA interferon-gamma release assays, LTBI latent tuberculosis infection, HMO health maintenance organization, POS point of service, PPO preferred provider organization

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