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Table 4 Factors associated with potential inappropriate, teratogen, progestogen drug prescriptions during pregnancy

From: Drug prescribing during pregnancy in a central region of Italy, 2008-2012

   Inappropriate drug prescriptionsa Teratogen drug prescriptions Progestogen drug prescriptions
   % OR adj IC 95% (inf-sup) % OR adj IC 95% (inf-sup) % OR adj IC 95% (inf-sup)
Socio-demographic variables
 Age classes ≤34 5.4 1   0.7 1   15.8 1   
35-39 7.8 1.54 1.47-1.61 0.9 1.45 1.29-1.64 25.4 1.88 1.83 1.92
≥40 11.4 2.23 2.08-2.38 1.2 1.99 1.68-2.35 33.5 2.68 2.58 2.79
 Nationality Other 6.4 1   0.8 1   12.9 1   
Italian 6.5 0.95 0.89-1.01 0.8 0.97 0.81-1.15 20.9 1.52 1.46 1.59
 Education None/elementary school 7.7 1   1.1 1   20.3 1   
Middle school 6.9 0.99 0.90-1.08 0.8 0.79 0.63-0.98 17.8 0.99 0.93 1.05
High school 6.5 0.86 0.79-0.94 0.8 0.67 0.55-0.83 20.4 1.04 0.99 1.10
Bachelor degree 5.9 0.72 0.65-0.79 0.7 0.57 0.45-0.72 21.8 0.97 0.92 1.02
Other variables
 Multiple pregnancies No 6.3 1   0.8 1   19.5 1   
Yes 21.1 3.75 3.37-4.17 0.9 1.03 0.71-1.50 50.9 3.91 3.65 4.19
 Parity Primiparous 6.7 1   0.8 1   21.9 1   
Multiparous 6.2 0.77 0.74-0.81 0.8 0.85 0.76-0.95 17.3 0.63 0.61 0.64
 Previous miscarriages (10 years before) None 6.1 1   0.8 1   18.7 1   
At least one 12.5 2.02 1.90-2.15 0.8 0.91 0.75-1.11 35.3 2.19 2.11 2.27
Comorbiditiesb
 Comorbidities None 6.4 1   0.7 1   19.9 1   
1 10.3 1.57 1.44-1.71 1.5 2.06 1.68-2.51 24.4 1.18 1.11 1.24
≥2 16.1 2.63 2.06-3.36 4.5 6.15 4.13-9.15 26.4 1.28 1.07 1.54
  1. awomen who had only progestogen prescriptions were not considered
  2. banemia, coagulation defects, cardiovascular disorders, congenital heart defects, congenital malformations of circulatory system; cerebrovascular disorders nephritis, nephrotic syndrome, and nephrosis; collagen diseases, HIV seropositive/AIDS; thyroid diseases; diabetes, hypertension, chronic obstructive pulmonary disease, asthma, cystic fibrosis, chronic pneumonia