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Table 4 Factors associated with potential inappropriate, teratogen, progestogen drug prescriptions during pregnancy

From: Drug prescribing during pregnancy in a central region of Italy, 2008-2012

  

Inappropriate drug prescriptionsa

Teratogen drug prescriptions

Progestogen drug prescriptions

  

%

OR adj

IC 95% (inf-sup)

%

OR adj

IC 95% (inf-sup)

%

OR adj

IC 95% (inf-sup)

Socio-demographic variables

 Age classes

≤34

5.4

1

 

0.7

1

 

15.8

1

  

35-39

7.8

1.54

1.47-1.61

0.9

1.45

1.29-1.64

25.4

1.88

1.83

1.92

≥40

11.4

2.23

2.08-2.38

1.2

1.99

1.68-2.35

33.5

2.68

2.58

2.79

 Nationality

Other

6.4

1

 

0.8

1

 

12.9

1

  

Italian

6.5

0.95

0.89-1.01

0.8

0.97

0.81-1.15

20.9

1.52

1.46

1.59

 Education

None/elementary school

7.7

1

 

1.1

1

 

20.3

1

  

Middle school

6.9

0.99

0.90-1.08

0.8

0.79

0.63-0.98

17.8

0.99

0.93

1.05

High school

6.5

0.86

0.79-0.94

0.8

0.67

0.55-0.83

20.4

1.04

0.99

1.10

Bachelor degree

5.9

0.72

0.65-0.79

0.7

0.57

0.45-0.72

21.8

0.97

0.92

1.02

Other variables

 Multiple pregnancies

No

6.3

1

 

0.8

1

 

19.5

1

  

Yes

21.1

3.75

3.37-4.17

0.9

1.03

0.71-1.50

50.9

3.91

3.65

4.19

 Parity

Primiparous

6.7

1

 

0.8

1

 

21.9

1

  

Multiparous

6.2

0.77

0.74-0.81

0.8

0.85

0.76-0.95

17.3

0.63

0.61

0.64

 Previous miscarriages (10 years before)

None

6.1

1

 

0.8

1

 

18.7

1

  

At least one

12.5

2.02

1.90-2.15

0.8

0.91

0.75-1.11

35.3

2.19

2.11

2.27

Comorbiditiesb

 Comorbidities

None

6.4

1

 

0.7

1

 

19.9

1

  

1

10.3

1.57

1.44-1.71

1.5

2.06

1.68-2.51

24.4

1.18

1.11

1.24

≥2

16.1

2.63

2.06-3.36

4.5

6.15

4.13-9.15

26.4

1.28

1.07

1.54

  1. awomen who had only progestogen prescriptions were not considered
  2. banemia, coagulation defects, cardiovascular disorders, congenital heart defects, congenital malformations of circulatory system; cerebrovascular disorders nephritis, nephrotic syndrome, and nephrosis; collagen diseases, HIV seropositive/AIDS; thyroid diseases; diabetes, hypertension, chronic obstructive pulmonary disease, asthma, cystic fibrosis, chronic pneumonia