Table 1 Sociodemographic, HIV-related variables, and comorbidities in patients newly diagnosed with HIV infection
|  | Period 1 | Period 2 | Period 3 | Period 4 | Period 5 | Total (n = 22,665) | P-value |
|---|---|---|---|---|---|---|---|
1/1/1998 to 12/31/2000 (n = 1373) | 1/1/2001 to 12/31/2003 (n = 2262) | 1/1/2004 to 12/31/2006 (n = 7774) | 1/1/2007 to 12/31/2009 (n = 5288) | 1/1/2010 to 12/31/2012 (n = 5968) | |||
Follow-up period, median (IQR; years) | 2 (1.94) | 2 (0.25) | 2 (0) | 2 (1.75) | 2 (1.92) | 2 (1.16) | < 0.001 |
Age, mean (IQR; years) | 34.56 (11.77) | 33.91 (11.66) | 33.05 (9.36) | 33.17 (10.44) | 31.08 (10.26) | 32.74 (10.31) | < 0.001 |
Age group, n (%) |  | < 0.001 | |||||
  ≤ 30 | 610 (44.4) | 1058 (46.8) | 3620 (46.6) | 2530 (47.8) | 3487 (58.4) | 11,305 (49.9) |  |
 31–40 | 445 (32.4) | 723 (32.0) | 2650 (34.1) | 1606 (30.4) | 1541 (25.8) | 6965 (30.7) |  |
 41–50 | 165 (12.0) | 260 (11.5) | 1113 (14.3) | 800 (15.1) | 624 (10.5) | 2962 (13.1) |  |
  ≥ 51 | 153 (11.1) | 221 (9.8) | 391 (5.0) | 352 (6.7) | 316 (5.3) | 1433 (6.3) |  |
Sex, n (%) | < 0.001 | ||||||
 Female | 116 (8.5) | 117 (5.2) | 809 (10.4) | 337 (6.4) | 201 (3.4) | 1580 (7.0) |  |
 Male | 1257 (91.5) | 2145 (94.8) | 6965 (89.6) | 4951 (93.6) | 5767 (96.6) | 21,085 (93.0) |  |
Income level, n (%) | < 0.001 | ||||||
 Low | 805 (58.6) | 1352 (59.8) | 6147 (79.1) | 2737 (51.8) | 2744 (46.0) | 13,785 (60.8) |  |
 Intermediate | 411 (29.9) | 585 (25.8) | 1109 (14.3) | 1928 (36.5) | 2388 (40.0) | 6421 (28.3) |  |
 High | 157 (11.4) | 325 (14.4) | 518 (6.6) | 623 (11.7) | 836 (14.0) | 2459 (10.9) |  |
Urbanization, n (%) | < 0.001 | ||||||
 Rural | 265 (19.3) | 475 (21.0) | 2933 (37.7) | 1774 (33.6) | 1937 (32.5) | 7384 (32.6) |  |
 Urban | 1108 (80.7) | 1787 (79.0) | 4841 (62.3) | 3514 (66.4) | 4031 (67.5) | 15,281 (67.4) |  |
HIV-transmission route, n (%) | < 0.001 | ||||||
 Homosexual contact | 574 (41.8) | 1125 (49.7) | 1532 (19.7) | 2516 (47.6) | 4032 (67.6) | 9779 (43.2) |  |
 Heterosexual contact | 578 (42.1) | 729 (32.2) | 974 (12.5) | 946 (17.9) | 925 (15.5) | 4152 (18.3) |  |
 Bisexual contact | 197 (14.4) | 278 (12.3) | 338 (4.4) | 453 (8.6) | 632 (10.6) | 1898 (8.4) |  |
 PWID | 15 (1.1) | 108 (4.8) | 4887 (62.9) | 1322 (25.0) | 314 (5.3) | 6646 (29.3) |  |
 Othera | 9 (0.6) | 22 (1.0) | 43 (0.5) | 51 (1.0) | 65 (1.1) | 190 (0.8) |  |
Comorbidities, n (%) | |||||||
 DM | 16 (1.2) | 60 (2.7) | 193 (2.5) | 144 (2.7) | 155 (2.6) | 568 (2.5) | < 0.05 |
 CKD | 13 (1.0) | 25 (1.1) | 94 (1.2) | 84 (1.6) | 91 (1.5) | 307 (1.4) | 0.114 |
 CHF | 4 (0.3) | 9 (0.4) | 23 (0.3) | 30 (0.6) | 26 (0.4) | 92 (0.4) | 0.177 |
 COPD | 24 (1.8) | 74 (3.3) | 173 (2.2) | 128 (2.4) | 108 (1.8) | 507 (2.2) | < 0.05 |
 Cancer | 44 (3.2) | 129 (5.7) | 439 (5.7) | 451 (8.5) | 583 (9.8) | 1646 (7.3) | < 0.001 |
 CVD | 12 (0.9) | 31 (1.4) | 83 (1.1) | 74 (1.4) | 57 (1.0) | 257 (1.1) | 0.121 |
HAART in each cohort period, n (%) | 605 (44.1) | 1273 (56.3) | 1546 (19.9) | 1237 (23.4) | 2345 (39.3) | 7006 (30.9) | < 0.001 |
AIDS incidence in each cohort period, n (%) | 438 (31.9) | 519 (22.9) | 1378 (17.7) | 1732 (32.8) | 2143 (35.9) | 6210 (27.4) | < 0.001 |
 AIDS incidence at presentation, n (%) | 395 (90.2) | 451 (86.9) | 819 (59.4) | 1274 (73.6) | 1632 (76.2) | 4571 (73.6) | < 0.001 |
 AIDS incidence during the follow-up period, n (%) | 43 (9.8) | 68 (13.1) | 559 (40.6) | 458 (26.4) | 511 (23.8) | 1639 (26.4) | < 0.001 |
HIV diagnosis region, n (%) | < 0.001 | ||||||
 Taipei area | 622 (45.3) | 1061 (46.9) | 2266 (29.2) | 1923 (36.4) | 2027 (34.0) | 7899 (34.9) |  |
 Northern Taiwan | 161 (11.7) | 262 (11.6) | 1278 (16.4) | 661 (12.5) | 850 (14.2) | 3212 (14.2) |  |
 Central Taiwan | 238 (17.3) | 339 (15.0) | 1539 (19.8) | 913 (17.3) | 1052 (17.6) | 4081 (18.0) |  |
 Southern Taiwan | 12 (0.9) | 244 (10.8) | 1057 (13.6) | 593 (11.2) | 669 (11.2) | 2687 (11.9) |  |
 Kaoping area | 192 (14.0) | 307 (13.6) | 1535 (19.8) | 1086 (20.5) | 1191 (20.0) | 4311 (19.0) |  |
 Eastern Taiwan | 36 (2.6) | 49 (2.2) | 99 (1.3) | 112 (2.1) | 179 (3.0) | 475 (2.1) |  |