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Table 1 Characteristics of studies on dietary isoflavones intake and risk of gastric cancer

From: The association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies

First author(year)
County [no.]
Study design Source of control Age (y) Dietary assessment Participants
(cases)
Intake comparison, high vs. Low (mg/d) OR (95%CI) for highest vs. lowest category NOS Score Adjustment for covariates
Hara (2012)
Japan [6]
Cohort Population 45–74 Validated FFQ 84,881
(1249)
M: 42.3 vs. 9.2 a
F: 41.8 vs. 9.4 a
M: 1 (0.81–1.24)
F:1.07 (0.77–1.5)
9 Age, public health center area, BMI, smoking, family history, ethanol, vegetable and fruit intake, fish intake, salt intake, and total energy intake, menopausal status
Wada (2015)
Japan [7]
Cohort Population > 35 169-item FFQ 30,792
(678)
M: 75.5 vs. 17.6 a
F: 72.6 vs. 20.1 a
M: 0.81 (0.60–1.09)
F: 0.60 (0.37–0.98)
9 Age, BMI, physical activity, smoking status, alcohol intake, salt intake, education, menopausal status
Rossi (2010)
Italy [11]
Case-control Hospital 22–80 Validated FFQ 777
(230)
> 34.3 vs. < 15.0 0.88 (0.53–1.46) 8 Sex, age, education, calendar year of interview, BMI, smoking intake, total energy intake
Lagiou (2004)
Boston [9]
Case-control Hospital NR Validated FFQ 210
(110)
2.85 vs. 0.01 a 1.16 (0.73–1.84) 7.5 Age, sex, place of birth, BMI, height, education, smoking and alcohol consumption, total energy intake, fruit and vegetable intake
Petrick (2015)
America [10]
Case-control Population 30–79 104-item FFQ 1913
(589)
GCA:0.6 vs. 0.27 a
OG:0.6 vs. 0.27 a
GCA:1.56 (0.93–2.6)
OG:1.5 (0.96–2.37)
9 Proxy status, income, education, BMI, cigarette and alcohol consumption
Woo (2014)
Korea [12]
Case-control Hospital 35–75 103-item FFQ 334
(334)
43.7 vs. 11.4 a M:0.98 (0.56–1.73)
F:0.67 (0.31–1.47)
6 Age, BMI, total energy intake, H.pyloristatus, occupation, smoking and alcohol intake, meat intake, fruits and vegetables intake, physical activity
Zamora-Ros (2012) Europe [8] Cohort Population 35–70 Validated FFQ 477,312
(683)
> 1.1 vs. < 0.3 M: 0.77 (0.5–1.18)
F: 1.05 (0.61–1.82)
9 Age, BMI, education, smoking, alcohol, physical activity, energy intake, fruit and vegetables intake, red and processed meat intake
  1. Abbreviations: NR not report, OG gastric adenocarcinoma, GCA gastric cardia adenocarcinoma, F female, M male, OR odds ratio
  2. a Median