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Table 3 Combination antiretroviral therapy (cART) regimen and patient biomedical and demographic factors independently associated with the development of diabetes mellitus-related comorbidities (DRCs). Status or event variable: Diabetes mellitus-related comorbidities (DRCs, N = 531)

From: Relationship between combination antiretroviral therapy regimens and diabetes mellitus-related comorbidities among HIV patients in Gaborone Botswana

Covariates Proportion Number (%) Unadjusted Adjusted
HR 95%CI HR 95%CI
cART Line1 0318 (59.9.1) 1 1
cART Line2/3 213 (40.1) 0.49* 0.31–0.79 0.53* 0.33–0.87
CD4–1 > 200 cells/mm3 407 (76.6) 1 1
CD4–1 ≤ 200 cells/mm3 124 (23.4) 1.6* 1.03–3.2 1.68* 1.03–2.73
Adherence
No 31 (5.8) 1 1
Yes 478 (90.0) 4.53* 1.42–14.5 3.05© 0.92–10.0
Unknown 22 (4.1) 1.14 0.41–3.12 0.89 0.32–2.51
BMI at cART
Normal Weight 337 (63.5) 1 1
Under weight 80 (15.1) 0.88 0.46–1.69 0.74 0.37–1.44
Overweight 114 (21.4) 1.6* 1.02–2.61 1.63* 1.07–2.64
Female 368 (69.3) 1 1
Male 163 (30.7) 0.58* 0.38–0.89 0.49* 0.32–0.77
  1. likelihood chi-square statistic = 36.25, p = 0.0001; CD4–1 = CD4 at initiation on cART, HR = Hazard ratio, CI = confidence interval, BMI at cART = BMI at initiation on cART, *P < 0.05, ©p = 0.06 (borderline); note that all variables, including age as continuous variable or age groups, that did not achieve p < 0.05 are not included in this model