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Table 4 Cox proportional hazards of incident rectal cancer according to BMI, sedentary behaviour and types of physical activity

From: Physical activity, obesity and sedentary behaviour and the risks of colon and rectal cancers in the 45 and up study

Variable Events No person-years Age-adjusted HR Multivariable HR(1)
BMI Kg/m2
 15- < 23.6 93 154,782 1.00 1.00
  ≥ 23.6- < 26.2 93 150,905 1.03 (0.77–1.37) 0.84 (0.62–1.14)
  ≥ 26.2- < 29.4 87 156,855 0.92 (0.69–1.24) 0.73 (0.54–1.00)
  ≥ 29.4-≤50 93 156,110 0.99 (0.74–1.32) 0.76 (0.55–1.04)
 Unknown n.p 3273 1.52 (0.48–4.81) 0.89 (0.22–3.62)
P-value(a)     0.20
 P-trend(b)     0.12
Sitting hours/day
 0- < 3 50 87,149 1.00 1.00
 3- < 5 100 167,893 1.04 (0.74–1.46) 1.03 (0.72–1.48)
 5- < 8 111 178,263 1.09 (0.78–1.52) 1.10 (0.77–1.57)
 8+ 72 143,988 0.87 (0.61–1.25) 0.90 (0.61–1.32)
 Unknown 36 44,633 1.41 (0.92–2.16) 1.07 (0.66–1.74)
P-value(a)     0.65
 P-trend(b)     0.40
Moderate activity minutes/week
 None 20 30,195 1.00 1.00
  > 0–149 77 102,607 0.85 (0.52–1.39) 0.85 (0.51–1.43)
 150 or more 252 433,967 0.88 (0.56–1.38) 0.93 (0.57–1.51)
 Unknown 20 20,487 1.47 (0.79–2.73) 1.17 (0.57–2.38)
 P-value(a)     0.77
 P-trend(b)     0.21
Vigorous activity minutes/week
 None 163 270,375 1.00 1.00
  > 0–74 53 102,607 0.86 (0.63–1.17) 0.98 (0.71–1.36)
 75 or more 58 145,748 0.66 (0.49–0.89) 0.70 (0.50–0.98)
 Unknown 95 103,194 1.52 (1.18–1.96) 1.34 (1.01–1.79)
P-value(a)     0.11
 P-trend(b)     0.78
  1. (1)Multivariable models adjusted for: birth cohort, sex, education, BMI, sitting time, time spent on moderate and vigorous activity, smoking, alcohol, country of birth, guidelines of fruit and vegetables, weekly intake of processed food, red meat and fibre, aspirin use, parental history of CRC and history of colorectal testing
  2. (a)P-value’ for each variable corresponds to a test of whether all HRs = 1
  3. (b)‘P-trend’ is for test of linear association in the log hazard scale and obtained by substituting the categorical versions of covariates in the Cox model with continuous or ordinal versions where appropriate
  4. ‘Unknown’ category was excluded from the estimation of P-values and P-trends
  5. n.p Not publishable because of small number, confidentiality or ethical concerns about the data