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Table 6 Clinical laboratory tests

From: A randomised, controlled, two-Centre open-label study in healthy Japanese subjects to evaluate the effect on biomarkers of exposure of switching from a conventional cigarette to a tobacco heating product

Serum biochemistry Haematology
 Aspartate aminotransferase (AST)  Haemoglobin
 Alanine aminotransferase (ALT)  Haematocrit (packed cell volume [PCV])
 Alkaline phosphatase  Total and differential leukocyte count
 Gamma-glutamyl transferase (GGT)  Red blood cell (RBC) count
 Sodium  Platelet count
 Potassium  Mean cell volume (MCV)
 Chloride  Mean cell haemoglobin (MCH)
 Calcium  MCH concentration (MCHC)
 Inorganic phosphate Urinalysis:
 Glucose  Microscopic examination
 Urea  pH
 Uric acid  Specific gravity
 Total bilirubin  Protein
 Direct bilirubin  Glucose
 Creatinine  Ketones
 Total protein  Bilirubin
 Albumin  Blood
 Total cholesterol  Nitrite
 Triglycerides  Urobilinogen
 Creatinine phosphokinase (CPK)  Leukocytes
 Blood urea nitrogen (BUN)  Urine pregnancy testd
Serologya  Urine drug screene
 Hepatitis B surface antigen (HBsAg) Additional Tests
 Hepatitis C antibody  Alcohol breath test
 Human immunodeficiency virus (HIV)c
Hormone Panelb  
 Follicle-stimulating hormone (FSH)  
 Human chorionic gonadotropin (hCG; serum pregnancy test)  
  1. aScreening only
  2. bIn all females at screening only
  3. cHIV1/2 and p24 antigen
  4. dIn all females. A positive urine pregnancy test will be confirmed with a serum pregnancy test
  5. eUrine drugs of abuse screen will be conducted for amphetamines, barbiturates, benzodiazepines, cocaine, ecstasy, methamphetamine, morphine, methadone, tricyclic antidepressants, and tetrahydrocannabinol