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Table 4 Schedule for exposure periods (Day 2 evening – Day7)

From: A randomised, controlled, two-Centre open-label study in healthy Japanese subjects to evaluate the effect on biomarkers of exposure of switching from a conventional cigarette to a tobacco heating product

Day Start of Procedure Procedure
2 19:00–20:00 c End of second 24-h urine and product use monitoring, start of third 24-h urine and product use monitoring.
Switch to next assigned product (Groups A to E) or cessation (Group F)
20:00–22:00 Snack
00:00 Designated smoking room closed
3, 4, 5, 6 06:00 Designated smoking room opened for use
06:00–09:00 Breakfast
12:00–14:00 Lunch
15:30–16:30a Blood sample collection for WBC (Day 5 only)
16:30–17:30b Exhaled CO assessment
18:00–19:00 Dinner
19:00–20:00c End of 24-h urine and product use monitoring, start of next 24-h urine and product use monitoring
20:00–22:00 Snack
00:00 Designated smoking room closed
7 06:00 Designated smoking room opened for use
06:00–09:00 Breakfast
12:00–14:00 Lunch
15:30–16:30a Blood sample collection for WBC
16:30–17:30b Exhaled CO assessment
18:00–19:00 Dinner
19:00–20:00c End of 24-h urine and product use monitoring
End of product use Groups A to E
  1. CO carbon monoxide, WBC white blood cells. aTime of blood sampling for WBC for individual subjects should be taken at the same time on each sampling day. bExhaled CO assessments for individual subjects should be taken at the same time on each sampling day. cEnd of 24-h urine collection needs to be time-matched to the start of 24-h urine collection for each individual subject