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Table 3 Schedule for baseline study period (Days −1 to 2)

From: A randomised, controlled, two-Centre open-label study in healthy Japanese subjects to evaluate the effect on biomarkers of exposure of switching from a conventional cigarette to a tobacco heating product

Day Start of Procedure Procedure
-1 12:00–19:00 Admission procedures: medical history, supine BP, PR, RR, axillary body temperature, abbreviated physical examination, lung function test, drug screen, alcohol breath test, urine cotinine test, exhaled CO test, urine pregnancy test for females, product test, dinner
19:00–20:00 Start of urine collection, start of monitoring conventional cigarette consumption
20:00–22:00 Snack
00:00 Designated smoking room closed
1 06:00 Designated smoking room opened for use
06:00–09:00 Breakfast
12:00–14:00 Lunch
16:30–17:30a Exhaled CO assessment
18:00–19:00 Dinner
19:00–20:00b End of first 24-h urine and cigarette use monitoring, start of second 24-h urine and cigarette use monitoring
20:00–22:00 Snack
00:00 Designated smoking room closed
2 06:00 Designated smoking room opened for use
06:00–09:00 Breakfast
12:00–14:00 Lunch
15:30–16:30c Blood sample collection for WBC
16:30–17:30a Exhaled CO assessment
18:00–19:00 Dinner
  1. BP blood pressure, CO carbon monoxide, PR pulse rate RR respiration rate, WBC white blood cells. aExhaled CO assessments for individual subjects should be taken at the same time on each sampling day. bEnd of 24-h urine collection needs to be time-matched to the start of 24-h urine collection for each individual subject. cTime of blood sampling for WBC for individual subjects should be taken at the same time on each sampling day