A randomised, controlled, two-Centre open-label study in healthy Japanese subjects to evaluate the effect on biomarkers of exposure of switching from a conventional cigarette to a tobacco heating product

Table 2 Investigational Products. Details of the investigational products to be used in this study. The target values for nicotine content are manufacturing specifications and the actual results may vary due to product variation, but these values will be within an appropriate range

Study Product Reference	Format	Product & Manufacturer	ISO Nicotine Yield	ISO Tar Yield
A	Combustible tobacco cigarette (non-menthol)	Lucky Strike Regular, BAT	0.63 mg/cig	7 mg/cig
B	THP (non-menthol)	Glo device with Neostik, BAT	0.47 mg/stick	N/A
C	Combustible tobacco cigarette (menthol)	Lucky Strike Menthol, BAT	0.63 mg/cig	7 mg/cig
D	THP (menthol)	Glo device with mentholated Neostik, BAT	0.47 mg/stick	N/A
E	THP (non-menthol)	iQos device with Marlboro Heatsticks^#	0.4 mg/stick	N/A

BAT British American Tobacco, THP tobacco heating product, THD tobacco heating device, ISO International Organisation for Standardisation. ^#Commercially-available products manufactured by Philip Morris International and procured from general a retail source in Japan
The combustible cigarettes (Products A and C) and Product E are commercially available products

ISSN: 1471-2458