|
BoE
|
Abbreviation
|
Associated Toxicant
|
Matrix
|
|
Carbon monoxide
|
CO
|
Carbon monoxide
|
Exhaled breath
|
|
Total nicotine equivalents (nicotine, cotinine, 3-hydroxycotinine and their glucuronide conjugates)
|
TNeq
|
Nicotine
|
Urine
|
|
Total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
|
Total NNAL
|
4 (methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
|
Urine
|
|
Total N-nitrosonornicotine
|
Total NNN
|
NNN
|
Urine
|
|
3-hydroxypropylmercapturic acid
|
3-HPMA
|
Acrolein
|
Urine
|
|
3-hydroxy-1-methylpropylmercapturic acid
|
HMPMA
|
Crotonaldehyde
|
Urine
|
|
S-phenylmercapturic acid
|
S-PMA
|
Benzene
|
Urine
|
|
Monohydroxybutenyl-mercapturic acid
|
MHBMA
|
1,3-butadiene
|
Urine
|
|
2-cyanoethylmercapturic acid
|
CEMA
|
Acrylonitrile
|
Urine
|
|
4-aminobiphenyl
|
4-ABP
|
4-Aminobiphenyl
|
Urine
|
|
o-toluidine
|
o-Tol
|
o-Toluidine
|
Urine
|
|
2-aminonaphthalene
|
2-AN
|
2-Aminonaphthalene
|
Urine
|
|
1-hydroxypyrene
|
1-OHP
|
Pyrene
|
Urine
|
|
2-hydroxyethylmercapturic acid
|
HEMA
|
Ethylene oxide
|
Urine
|
|
N-acetyl-S-(2-carbamoylethyl)cysteine and N-acetyl-S-(2-hydroxy-2-carbamoylethyl)cysteine
|
AAMA and GAMA
|
Acrylamide
|
Urine
|
|
BoBE
|
Abbreviation
|
Biological Effect
|
Matrix
|
|
8-Epi-Prostaglandin F2α Type III
|
8-Epi-PGF2α Type III
|
Oxidative stress
|
Urine
|
|
White blood cell count
|
WBC count
|
Inflammation
|
Whole blood
|
|
Nicotine pharmacokinetic parameters
|
Abbreviation
|
|
Time to maximum observed plasma concentration for nicotine
|
tmax
|
|
Maximum observed plasma concentration for nicotine
|
Cmax
|
|
Area under the nicotine plasma concentration-time curve from time zero to the last measurable concentration
|
AUC0-last
|
|
Safety parameters
|
Other measures
|
|
Medical history of study subjects
|
Product satisfaction questionnaire
|
|
Physical examination
|
Puff count during pharmacokinetic assessment period
|
|
Vital signs
|
Creatinine concentration (24-h urine)
|
|
Electrocardiogram (ECG)
|
Product use during exposure phase
|
|
Clinical laboratory evaluations
|
Nicotine molar metabolite ratio
|
|
Lung function test
| |
|
Adverse event /serious adverse event recording
| |
