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Table 2 Prevalence of major underlying conditions/risk factor for pneumococcal disease according to age strata

From: Prevalence of high, medium and low-risk medical conditions for pneumococcal vaccination in Catalonian middle-aged and older adults: a population-based study

  50–64 yrs.
(N = 1,021,648)
n (%)
≥ 65 yrs.
(N = 1,011,817)
N (%)
ODDS RATIO
(OR)
OR 95%CI
Immunocompromising conditions
 Primary immunodeficiency 295 (<0.1) 294 (<0.1) 1.01 (0.85–1.19)
 HIV infection 2825 (0.3) 449 (<0.1) 0.16 (0.14–0.18)
 Nephrotic syndrome 577 (0.1) 903 (0.1) 1.58 (1.42–1.76)
 Severe renal failure (GFR < 30) 1058 (0.1) 14,410 (1.4) 13.94 (13.04–14.84)
 Bone marrow trasplantation 2415 (0.2) 2619 (0.3) 1.10 (1.04–1.16)
 Recent cancer 30,339 (3.0) 73,609 (7.3) 2.56 (2.53–2.68)
 Immunosuppressive medication/Radiotherapy 22,319 (2.2) 49,721 (4.9) 2.31 (2.28–2.35)
Other high risk condition
 Asplenia 186 (<0.1) 108 (<0.1) 0.59 (0.46–0.75)
 Cochlear implant 23 (<0.1) 53 (<0.1) 2.33 (1.39–3.91)
 CSF leaks 11 (<0.1) 30 (<0.1) 2.75 (1.33–5.83)
Chronic respiratory disease 67,987 (6.7) 144,268 (14.3) 2.33 (2.31–2.36)
Chronic heart disease 49,362 (4.8) 199,015 (19.7) 4.82 (4.77–4.87)
Liver disease 20,567 (2.0) 21,167 (2.1) 1.04 (1.02–1.06)
Diabetes mellitus 100,855 (9.9) 240,680 (23.8) 2.85 (2.83–2.87)
Alcoholism 36,808 (3.6) 21,973 (2.2) 0.59 (0.58–0.60)
Smoking 242,626 (23.7) 74,932 (7.4) 0.26 (0.25–0.27)
  1. Odds Ratios (ORs) were calculated for people ≥65 years as compared with people 50–64 years
  2. CI denotes confidence interval