Table 2 Prevalence of major underlying conditions/risk factor for pneumococcal disease according to age strata
50–64 yrs. (N = 1,021,648) n (%) | ≥ 65 yrs. (N = 1,011,817) N (%) | ODDS RATIO (OR) OR 95%CI | |
|---|---|---|---|
Immunocompromising conditions | |||
Primary immunodeficiency | 295 (<0.1) | 294 (<0.1) | 1.01 (0.85–1.19) |
HIV infection | 2825 (0.3) | 449 (<0.1) | 0.16 (0.14–0.18) |
Nephrotic syndrome | 577 (0.1) | 903 (0.1) | 1.58 (1.42–1.76) |
Severe renal failure (GFR < 30) | 1058 (0.1) | 14,410 (1.4) | 13.94 (13.04–14.84) |
Bone marrow trasplantation | 2415 (0.2) | 2619 (0.3) | 1.10 (1.04–1.16) |
Recent cancer | 30,339 (3.0) | 73,609 (7.3) | 2.56 (2.53–2.68) |
Immunosuppressive medication/Radiotherapy | 22,319 (2.2) | 49,721 (4.9) | 2.31 (2.28–2.35) |
Other high risk condition | |||
Asplenia | 186 (<0.1) | 108 (<0.1) | 0.59 (0.46–0.75) |
Cochlear implant | 23 (<0.1) | 53 (<0.1) | 2.33 (1.39–3.91) |
CSF leaks | 11 (<0.1) | 30 (<0.1) | 2.75 (1.33–5.83) |
Chronic respiratory disease | 67,987 (6.7) | 144,268 (14.3) | 2.33 (2.31–2.36) |
Chronic heart disease | 49,362 (4.8) | 199,015 (19.7) | 4.82 (4.77–4.87) |
Liver disease | 20,567 (2.0) | 21,167 (2.1) | 1.04 (1.02–1.06) |
Diabetes mellitus | 100,855 (9.9) | 240,680 (23.8) | 2.85 (2.83–2.87) |
Alcoholism | 36,808 (3.6) | 21,973 (2.2) | 0.59 (0.58–0.60) |
Smoking | 242,626 (23.7) | 74,932 (7.4) | 0.26 (0.25–0.27) |