Table 1 Prevalence of major underlying conditions/risk factor for pneumococcal disease, according to gender, in people over 50 years in Catalonia, Spain
MEN (N = 935,705) n (%) | WOMEN (N = 1,097,760) n (%) | ODDS RATIO (OR) OR 95%CI | OVERALL (N = 2,033,465) n (%) | |
|---|---|---|---|---|
Immunocompromising conditions | ||||
Primary immunodeficiency | 237 (<0.1) | 352 (<0.1) | 0.79 (0.67–0.93) | 589 (<0.1) |
HIV infection | 2533 (0.3) | 741 (0.1) | 4.02 (3.70–4.37) | 3274 (0.2) |
Nephrotic syndrome | 900 (0.1) | 580 (0.1) | 1.82 (1.64–2.02) | 1480 (0.1) |
Severe renal failure (GFR < 30) | 6106 (0.7) | 9362 (0.9) | 0.76 (0.74–0.79) | 15,468 (0.8) |
Bone marrow trasplantation | 3096 (0.3) | 1938 (0.2) | 1.88 (1.77–1.99) | 5034 (0.2) |
Recent cancer | 55,475 (5.9) | 48,473 (4.4) | 1.36 (1.35–1.38) | 103,948 (5.1) |
Immunosuppressive medication/Radiotherapy | 29,408 (3.1) | 42,632 (3.9) | 0.80 (0.79–0.82) | 72,040 (3.5) |
Other high risk conditions | ||||
Asplenia | 141 (<0.1) | 153 (<0.1) | 1.08 (0.85–1.37) | 294 (<0.1) |
Cochlear implant | 27 (<0.1) | 49 (<0.1) | 0.65 (0.39–1.07) | 76 (<0.1) |
CSF leaks | 17 (<0.1) | 24 (<0.1) | 0.85 (0.43–1.61) | 41 (<0.1) |
Chronic respiratory disease | 115,432 (12.3) | 96,823 (8.8) | 1.45 (1.44–1.47) | 212,255 (10.4) |
Chronic heart disease | 135,426 (14.5) | 112,951 (10.3) | 1.48 (1.46–1.49) | 248,377 (12.2) |
Chronic liver disease | 23,290 (2.5) | 18,444 (1.7) | 1.49 (1.46–1.52) | 41,734 (2.1) |
Diabetes mellitus | 183,649 (19.6) | 157,886 (14.4) | 1.45 (1.44–1.46) | 341,535 (16.8) |
Alcoholism | 51,031 (5.5) | 7750 (0.7) | 8.11 (7.92–8.31) | 58,781 (2.9) |
Smoking | 194,865 (20.8) | 122,693 (11.2) | 2.09 (2.07–2.10) | 317,558 (15.6) |