First author, publication year | Duration of study + years of FU | Location of study | Exclusion criteria | Cohort size | Number of cases (% of cohort) | Age at entry | Endpoint category a | Specific endpoint | ||
---|---|---|---|---|---|---|---|---|---|---|
CHD | CVA | CVD | ||||||||
Colditz 1987 [26] | En: ‘76 F: until ‘82 FU: 6 y | USA | Diagnoses of CHD at entry, non-married. (Note: only registered nurses, 98% white) | 119,963 women. 700,809 person years | 308 (2.6%) | 30–55 at entry | C |  |  | Incident cases non-fatal myocardial infarction or fatal CHD. |
Cooper 1999 [27] | En: ‘34-‘39 F: until ‘90–‘91. FU: 51–57 y | Minne-sota, USA | Enrolled white college students. In FU excluded if missing information age CVD event, or missing CVD data in questionnaire | 867. (714 self-administered FU, 153 proxy respondents (family members)) | 45 (35 non-fatal, 10 fatal) (5.2%) | Under 25 at entry, 63–81 at FU | C |  |  | Non-fatal and fatal CHD |
Otterblad- Olausson 2004 [9] | En:‘85 census. FU: From ‘90-‘95. FU: 5 y | Sweden | Women who had first infant before the age of 30 between 1964 and 1989 are included. Exclusion: women who emigrated or died between census and follow up. | 460,434 women | 151 (total circulatory) (0.05%), no data reported for CHD and cerebrovascular. | Born ‘50 – ‘64 → 21 to 35 at census. | M | M | M | Total circulatory, CHD, cerebrovascular mortality. |
Yang CY 2006 [38] | En: ‘78/‘87 F: until ‘03 FU: 16–25 y | Taiwan | Included women with a first and singleton childbirth between 1978 and 1987. | 1,292,462 women, 27,402,995 person years | 189 (0.01%) | ? |  | M |  | Subarachnoid hemorrhage mortality |
Henrettab 2007 [30] | En: ‘31/‘41 F: ‘92/‘02a | USA | First two follow up years excluded. People who didn’t survive until follow up excluded. | 4335 women | Heart disease: 13.2%, stroke: 8.9% (parous women) | Birth cohort ‘31-‘41. Age at FU: 51–61 through 61–71 | E | E |  | Presence of disease in 1994: heart, stroke. Self-reported. |
Sakauchi 2007 [36] | En:‘88/‘90 F: until ‘03. FU: 13–15 y | Japan | Previous history of cancer. Missing target question item. | 63,600 women at baseline, 817,669 person years | CHD: 458 (0.7%) Cerebrovascular: 1151 (1.8%) | 40 to 79 at entry. | M | M |  | CHD mortality, cerebrovascular mortality |
Yang L 2009 [39] | En: ‘91-‘92 F: until ‘04. FU: avg. 12.9 y | Sweden | Prior CVD. Missing information on OC use or smoking. Baseline self-reported natural menopause or HRT use. | 45,729 | Stroke: 285 (0.6%); Ischemic: 193 (0.4%) Hemorrhagic: 72 (0.2%) | 30–49 |  | C |  | Ischemic and Hemorrhagic stroke. |
Grundy 2010 [29] | En: ‘35/‘68 F:’ from ‘80 to ‘03. FU: 23 y | Norway | Analysis restricted to ages above 45 (largely completed childbearing for women). Men and women who died before this age were excluded | 744,784 women (7.2 million person years) 785,317 men (7.36 million person years) | 3605 women (0.5%) 12,640 men (1.6%) | Register data born ‘35-‘68. Mortality at 45–68 |  |  | M | Death from circulatory diseases |
Chang 2011 [25] | En: ‘85 FU: until ‘05 FU: 20 y | Kangwha, Korea | Ever on OC. Missing info on age menarche, MP, BMI, BP, AFB, gravidity or parity. | 3257 women. 48,313 person years | 478 (14.7%) | PostMP, 55 or older at entry | M | M | M | CVD mortality, CHD mortality, stroke mortality |
Gallagher 2011 [28] | En: ‘89-‘91 F: until ‘00 FU: 10/12 y | China | None mentioned | 267,400 women. 2,565,433 person years | CVD: 4349 (1.6%), Stroke: 2776 (0.9%), CHD: 494 (0.2%). | 30–60 at entry | M | M |  | CHD, ischemic and hemorrhagic stroke mortality. |
Webb 2011 [10] | En: ‘70 F: until ‘06 FU: max 37 y | England and Wales | Included women estimated to have reached age 13 during ‘70s-‘90s, sampled members of census ‘71, ‘81 and ‘91. | 1,913,595 person years | 133 (0.007%) | 13–49 | M |  |  | Heart disease mortality |
Merritt 2015 [32] | En: ‘92/‘00 F: Until ‘10. FU: mean 12.9 y | 10 western European countries | DM, myocardial infarction, angina, stroke, cancer. Report of a prevalent disease that could influence important confounders. Missing lifestyle questionnaire, vital status or date of death. Women reported never having menstruated or missing information on all reproductive variables. | 322,972 women | Circulatory: 2404 (0.7%); Cerebrovascular: 808 (0.3%); CHD: 732 (0.2%) | 25–70 at entry | M | M | M | Total circulatory, cerebrovascular, and CHD mortality |
Barclay 2016 [22] | En: ‘32 - ‘60 F: ‘90 - ‘12 FU: 22 y | Sweden | This is a sibling study: ID for both parents needed, no multiple births, no only children, no childless individuals, no variance on either mortality or AFB. | 12,635 women, 27,183 men | 4503 women (35.6% 10,067 men (37.0%) | People enter cohort in ‘90 or after age 45. Ages 45–80 throughout follow-up. |  |  | M | Circulatory deaths |
Parikh 2016 [35] | En: ‘91 F: until ‘10 FU: median 12 years | USA | Missing reproductive and CHD risk factor information, missing follow up, prevalent or unknown history of CHD. | 72,982 | 4607(6.3%) | Mean age at start of study 63.2 | E |  |  | Coronary Heart Disease events |