Risk of chronic liver disease in post-menopausal women due to body mass index, alcohol and their interaction: a prospective nested cohort study within the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

Table 2 Event rates and adjusted hazard ratios of first liver-related events, according to BMI category and according to alcohol category

BMI and alcohol categories	First event rate per 1000 person years (95% confidence intervals)	Hazard ratio (95% confidence intervals)^a	Hazard ratio (95% confidence intervals)^b
BMI category (kg/m²)
< 25	0.45 (0.4–0.5)	1 (reference)	1 (reference)
25 - <30	0.65 (0.5–0.8)	1.44 (1.10–1.87)	1.31 (1.01–1.72)
≥ 30	1.06 (0.9–1.3)	2.25 (1.70–2.97)	1.85 (1.38–2.48)
Alcohol category (units/week)
None	0.86 (0.7–1.0)	1 (reference)	1 (reference)
< 1–15	0.55 (0.5–0.6)	0.70 (0.55–0.88)	0.78 (0.61–1.00)
16–20	0.68 (0.3–1.2)	0.93 (0.50–1.73)	0.97 (0.52–1.82)
≥ 21	1.37 (0.7–2.5)	1.82 (0.97–3.39)	1.83 (0.97–3.44)

^aAdjusted for BMI (continuous variable) or alcohol category as appropriate ^bAdjusted for BMI (continuous variable) or alcohol category as appropriate and smoking, hypertension, heart disease, hypercholesterolaemia, diabetes and IMD

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