Table 3 Duration, adherence, and side effects of preconception and prenatal supplements among 4417 women participating in PRECONCEPT a micronutrient supplementation trial in Vietnam

Duration of supplementation (weeks)

54.0 ± 29.3

57.2 ± 28.7

57.1 ± 28.6 ^a

 100%

17.2

14.6

14.7

 80–99%

60.3

63.3

63.3

  < 80%

22.5

22.1

21.9

Reported side effects (any; %)

31.0

19.2

15.8^a,b

 Fever (%)

2.8

2.8

2.3

 Vomiting (%)

6.5

2.4

2.2^a

 Nausea (%)

20.2

9.3

7.3^a

 Bloody stool (dark color) (%)

5.0

4.7

2.7^a,b

 Diarrhea (%)

2.6

2.0

2.1

 Headache (%)

13.3

9.9

8.2^a,b

 Vaginal Discharge (%)

1.6

1.5

1.4

Reported aftertaste (%)

13.1

8.0

6.6^a,b

Prenatal Supplement^d,e

MM (370)

IFA (404)

FA (409)^f

Duration (weeks)

27.7 ± 8.0

27.5 ± 8.6

28.6 ± 7.9

 100%

19.5

23.2

17.9

 80–99%

65.1

58.4

65.3

  < 80%

18.0

18.5

19.0

Reported side effects (any; %)

12.4

15.3

13.9

 Fever (%)

1.1

2.0

1.2

 Vomiting (%)

4.6

5.7

4.7

 Nausea (%)

7.6

5.9

9.1

 Bloody stool (dark color) (%)

2.4

4.7

1.5

 Diarrhea (%)

0.8

2.2

1.0

 Headache (%)

4.3

3.7

4.4

 Vaginal Discharge (%)

1.1

0.7

1.5

Reported aftertaste (%)

1.4

2.0

2.2