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Table 7 Prevention strategies

From: Systematic review of cost-effectiveness analyses for combinations of prevention strategies against human papillomavirus (HPV) infection: a general trend

  Kulasingam 2003 [27] Sanders 2003 [28] Goldie 2004 [29] Taira 2004 [32] Kulasingam 2007 [39]
Strategy assessed .No Intervention
.Vaccination only (12 F)
.Cytology 18 F - 5y
. Cytology 18 F - 3y
. Cytology 18 F - 2y
. Cytology 18 F - 1y
.Vaccination (12 F) + Cytology 30 F - 5y
.Vaccination (12 F) + Cytology 18 F - 5y
.Vaccination (12 F) + Cytology 26 F - 3y
.Vaccination (12 F) + Cytology 18 F - 3y
.Vaccination (12 F) + Cytology 24 F - 2y
.Vaccination (12 F) + Cytology 18 F - 2y
.Vaccination (12 F) + Cytology 22 F - 1y
.Vaccination (12 F) + Cytology 18 F - 1y
.Cytology (16 F) - 2y (.Vaccination (12 F) + Cytology (16 F) - 1y)
.Vaccination (12 F) + Cytology (16 F) - 2y
(.Vaccination (12 F) + Cytology (16 F) - 3y
.Vaccination (12 F) + Cytology (16 F) - 4y
.Vaccination (12 F) + Cytology (16 F) - 5y)
.No intervention
.Cytology 35 F - 5y
.Cytology 30 F - 5y
.Cytology 25 F - 5y
.Vaccination (12 F) + Cytology 35 F - 5y
.Vaccination (12 F) + Cytology 30 F - 5y
.Vaccination (12 F) + Cytology 25 F - 5y
.Vaccination (12 F) + Cytology 21 F - 5y
.Vaccination (12 F) + Cytology 25 F - 3y
.Vaccination (12 F) + Cytology 21 F - 3y
.Vaccination (12 F) + Cytology 21 F - 2y
.Vaccination (12 F) + Cytology 18 F - 2y
.Vaccination (12 F) + Cytology LBC 18 F - 2y
.Vaccination (12 F) + Cytology 18 F - 1y
.Vaccination (12 F) + Cytology LBC 18 F - 1y
. Cytology ?F - 2y (.Vaccination (12 F) + Cytology ?F - 4y
.Vaccination (12 F) + Cytology ?F - 3y))
.Vaccination (12 F) + Cytology ?F - 2y
(.Vaccination (12 F) + Cytology ?F - 1y)
.No intervention
.Vaccination only (12 F)
.Cytology 18-21 F - 2y
.Vaccination (12 F) + Cytology 18-21 F - 2y
.Vaccination (12 F) + Cytology 18-21 F - 3y
.Vaccination (12 F) + Cytology 25 F - 3y
Results ICER/life year gained, reduction in cervical cancer incidence and mortality ICER/QALY gained, reduction in cervical cancer incidence and mortality ICER/QALY gained, reduction in lifetime risk of cervical cancer ICER/QALY gained ICER/life year gained
  Goldhaber-Fiebert 2008 [33] Kim 2008 [31] Coupe, de Melker 2009 [35] Coupe, van Ginkel 2009 [36] Kim 2009 [30]
Strategy assessed .No intervention
.Vaccination only (9 F)
.Cytology 18 F,21 F,25 F – 5y,3y,2y,1y + HPV triage (Switch 25y,30y,35y)
.HPV 18 F - 1y + Cytology triage
.Vaccination (9 F) + Cytology 18 F,21 F,25 F – 5y,3y,2y,1y + HPV triage (Switch none, 25y,30y,35y)
.Vaccination (9 F) + HPV 25 F - 3y + Cytology triage
.Cytology 20 F - 1y
.Cytology 20 F - 2y
.Cytology 20 F - 3y + HPV Triage
.Vaccination (12 F) + Cytology 20 F - 1y
.Vaccination (12 F) + Cytology 20 F - 2y
.Vaccination (12 F) + Cytology 20 F - 3y + HPV Triage
.Vaccination only (12 F)
.Cytology 30 F,35 F - 4,5,6,7 rounds
.Cytology + HPV triage 30 F,35 F - 4,5,6,7 rounds
.HPV + Cytology triage 30 F,35 F - 4,5,6,7 rounds
.Cytology & HPV 30 F,35 F - 4,5,6,7 rounds
.Cytology 30 F - 5y
.Vaccination (12 F) + Cytology 30 F - 5y
.Cytology 25 F/M - 3y + HVP triage
.Vaccination (12 F) + Cytology 25 F/M - 3y + HVP triage
.Cytology 25 F/M - 2y + HVP triage
.Vaccination 12 F/M + Cytology 25 F/M - 3y + HVP triage
.Vaccination 12 F + Cytology 25 F/M - 2y
+ HVP triage
.Vaccination 12 F/M + Cytology 25 F/M - 2y
+ HVP triage
Results ICER/QALY gained, reductions in
cervical cancer
ICER/QALY gained, reductions in
cervical cancer
ICER/QALY gained, cervical cancer cases and cervical cancer deaths avoid ICER/QALY gained, cervical cancer cases and cervical cancer deaths avoid ICER/QALY gained,
  Kim, Ortendahl 2009 [34] Accetta 2010 [38] Diaz 2010 [43] Demarteau 2011 [41] Burger 2012 [42]
Strategy assessed .Cytology + HPV triage lifetime for 35 F every 1y, 2y, 3y, 4y
.Cytology + HPV triage + Combined cytology/HPV after 35 F every 1y, 2y, 3y, 4y
.Cytology + HPV triage lifetime for 45 F every 1y, 2y, 3y, 4y
.Cytology + HPV triage + Combined cytology/HPV after 45 F every 1y, 2y, 3y, 4y
.No intervention
.Cytology 25 F - 3y
.Cytology 25 F - 5y
.HPV DNA 25 F - 3y
.HPV DNA 25 F - 5y
.Cytology 25 F - 3y + HPV triage
.Cytology 25 F - 5y + HPV triage
.HPV DNA 25 F - 3y + Pap Triage
.HPV DNA 25 F - 5y + Pap Triage
.Vaccination only (11 F)
.Vaccination (11 F) + Cytology 25 F - 3y
.Vaccination (11 F) + Cytology 25 F - 5y
.Vaccination (11 F) + HPV DNA 25 F - 3y
.Vaccination (11 F) + HPV DNA 25 F - 5y
.Vaccination (11 F) + Cytology 25 F - 3y + HPV triage
.Vaccination (11 F) + Cytology 25 F - 5y + HPV triage
.Vaccination (11 F) + HPV DNA 25 F - 3y + Pap Triage
.Vaccination (11 F) + HPV DNA 25 F - 5y + Pap Triage
.Cytology alone
.Cytology with HPV triage
.Combined cytology and HPV
.Vaccination + cytology alone
.Vaccination + cytology with HPV triage
.Vaccination + combined cytology and HPV
.Cytology ?F – 3y
.Vaccination (12 F) + Cytology ?F – 3y
(.Cytology ?F – 1y
.Vaccination (12 F) + Cytology ?F – 1y
.Cytology ?F – 5y
.Vaccination (12 F) + Cytology ?F – 5y)
.No vaccinated
.Vaccinated only (12 F)
.Screening frequency 3y to 6y, wait time for rescreen 6 m or 12 m, additional HPV+/Cyt- 1 to 3
Results ICER/QALY gained, reductions in lifetime risk of cervical cancer ICER/life year gained, lifetime risk of cervical cancer, reduction in cancer risk, cervical cancer mortality ICER/life year gained, reduction in cervical cancer ICER/QALY gained ICER/life year gained, reduction in
cancer
  Coupe 2012 [37] Tully 2012 [40] Berkhof 2013 [44]   
Strategy assessed .Cytology 30 F - 5y
.Vaccination only
.Vaccination + Cytology 30 F-7 times
.Vaccination + Cytology 30 F-6 times
.Vaccination + Cytology 30 F-5 times
.Vaccination + Cytology 30 F-4 times
.Vaccination + HPV DNA screening-7 times + cytological triage
.Vaccination + HPV DNA screening-6 times + cytological triage
.Vaccination + HPV DNA screening-5 times + cytological triage
.Vaccination + HPV DNA screening-4 times + cytological triage
.Vaccination (12 F) + Cytology 21 F
.Vaccination (12 F) + Cytology 25 F
.Vaccination only (12 F)
.10,6,3-yearly Pap
.10,6,3-yearly HPV
.Vaccination (12 F) +10-yearly Pap
.Vaccination (12 F) +10-yearly HPV
.Vaccination (12 F) +6-yearly Pap
.Vaccination (12 F) +6-yearly HPV
  
Results ICER/QALY gained, cancer cases and deaths ICER/QALY gained, ICER/life year gained ICER/QALY gained