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Table 1 Vaccination strategies

From: Systematic review of cost-effectiveness analyses for combinations of prevention strategies against human papillomavirus (HPV) infection: a general trend

 

Kulasingam 2003 [27]

Sanders 2003 [28]

Goldie 2004 [29]

Taira 2004 [32]

Kulasingam 2007 [39]

Vaccine considered

Bivalent

Bivalent

Bivalent

Bivalent

Bivalent

Age of vaccination (y)

12 (12–19)

12 (12–15)

12 (12–15)

12

12

Catch-up

-

-

-

-

-

Booster

0 (1)

10y (3y-lifetime)

- (Yes)

10y

- (1)

Vaccine price (3 doses)

$200 ($100–$600)

$300 ($100–$500)

$377 ($188–$565)

$300 ($100–$400)

AUS$345 ($300–$450)

Coverage

100% (50–100%)

-

100% (50–100%)

-

80% (70–90%)

Compliance

100%

70% (30–100%)

100%

-

-

Efficacy

90% (25–100%)

75% (0–100%)

90% (50–100%)

90% (10–90%)

100% (93–100%)

Protection duration (y)

10 (2–30)

10

-

-

Lifetime

Waning effect

-

-

No (5,10,15,20y)

Yes (No)

-

Herd Immunity

-

-

-

-

Considered in SA

 

Goldhaber-Fiebert 2008 [33]

Kim 2008 [31]

Coupe, de Melker 2009 [35]

Coupe, van Ginkel 2009 [36]

Kim 2009 [30]

Vaccine considered

Bivalent

Bi/Quadrivalent

Bivalent

Bivalent

Bi/Quadrivalent

Age of vaccination

9

12

12

12

12

Catch-up

In SA

18,21,26y

-

-

-

Booster

-

10y

-

30y in SA

-

Vaccine price (3 doses)

$402 ($300–$900)

$360

€ 375

€ 375

$360

Coverage

25%, 75%, and 100%

75%

100%

85%

-

Compliance

-

-

100%

-

100%

Efficacy

100% (75%)

100%

95%

95% (85-90-98%)

Infection: ♀ 100%/♂ 85% Disease: ♀ 100%/♂ 90%

Protection duration

Lifetime (15y)

Lifetime

Lifetime

Lifetime

Lifetime

Waning effect

-

10 years

10 or 20 years

- (exponential decrease in efficacy of 50% during each following 20 years 10y, or 5 years)

-

Herd Immunity

- (Yes)

-

-

-

Yes

 

Kim, Ortendahl 2009 [34]

Accetta 2010 [38]

Diaz 2010 [43]

Demarteau 2011 [41]

Burger 2012 [42]

Vaccine considered

Bivalent

Bivalent

Bivalent

Bivalent

Quadrivalent

Age of vaccination

35

11

11

12

12

Catch-up

-

Yes

-

up to 25y in SA

-

Booster

-(Yes)

-(10–20y)

No

- (1)

-

Vaccine price (3 doses)

$402 ($250–$750)

€ 309.23 (€90)

€ 312 (€150–€600)

€ 401 (€321–€482)

$489

Coverage

Not clear

100%

90% (50–100%)

-

-

Compliance

100%

-

-

-

-

Efficacy

100% (70%)

75.90% (95%)

100% (60–100%)

98% (78–100%)

-

Protection duration

Lifetime

-

Lifetime (10y)

-

-

Waning effect

-(5–10y)

-

-

-(15–20y)

-

Herd Immunity

-

-

-

-

-

 

Coupe 2012 [37]

Tully 2012 [40]

Berkhof 2013 [44]

 

Vaccine considered

Bivalent & multivalent

Bivalent

Bivalent

Age of vaccination

Not Clear

12

12

 

Catch-up

-

18y in SA

-

Booster

-

25y in SA

-

Vaccine price (3 doses)

-

$270 CAD

$300

Coverage

100%

80%

70%

Compliance

-

-

-

Efficacy

95%

>90%

-

Protection duration

Lifetime

Lifetime

-

Waning effect

-(Yes)

Considered in SA (unavailable)

-

Herd Immunity

-

Accounted

-