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Fig. 4 | BMC Public Health

Fig. 4

From: Health economic evaluation of Human Papillomavirus vaccines in women from Venezuela by a lifetime Markov cohort model

Fig. 4

Deterministic sensitivity analysis – a) Scenario 2 Tornado graph for costs differences in scenario 2 (same vaccine price per dose of 8.5 US$, exchange rate of 6.3 VEF, scheme of 2 doses) b) Scenario 4 Tornado graph for costs differences in scenario 4 (same vaccine price per dose of 8.5 US$, exchange rate of 170 VEF, scheme of 2 doses). Discount rate = 5%. Abbreviations: COSTS_Genital Wart = Costs of genital warts management; COSTS_Cancer = Costs of cervical cancer management; COSTS_Vaccine cervarix = Cost of quadrivalent vaccine; COST_Vaccine Gardasil = Cost of bivalent vaccine; Scenario_Crossprotection = refers to the presence of lifetime cross-protection or no cross-protection at all; T_pob: HPVlr_NoHPV = transition probability to regress from low-risk HPV to no HPV; T_prob: HPVOnc_NoHPV = Transition probability to regress from infection with oncogenic HPV to no HPV; T_prob: HPVOnc_CIN1 = Transition probability to progress from infection with oncogenic HPV to CIN1; T_prob: CIN1Onc_CIN2/3 = Transition probability to progress from infection with oncogenic HPV and CIN1 to CIN2/3; T_prob: CIN2/3_Cancer = Transition probability to progress from CIN2/3 to cancer; T_prob: CIN1Onc_cured = Transition probability to cure from oncogenic HPV infection with CIN1; T_prob: CIN2/3_Cured = Transition probability to cure from CIN2/3; T_prob: Cancer_Cured = Transition probability to cure from cervical cancer; Vac_efficacy_1618_Cervarix = Vaccine efficacy for oncogenic types with quadrivalent vaccine; Vac_efficacy_1618_Gardasil = Vaccine efficacy for oncogenic types with bivalent vaccine; Vac_eff_other_Gardasil = Vaccine efficacy for non-vaccine oncogenic HPV types with bivalent vaccine; Perc_HPV_6_11 = Proportion of HPV 6 and 11 in genital warts; Perc_other_CC = Proportion of non-vaccine oncogenic HPV types among Cervical Cancer; Perc_HPVOnc = Proportion of HPV 16 and 18 among Cervical Cancer; HPV: Human Papillomavirus; VEF: Venezuelan bolívar fuerte; US$: United States dollar

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