Skip to main content

Table 2 Results of cohort studies included in the systematic review for the asbestos-smoking interaction

From: Absence of multiplicative interactions between occupational lung carcinogens and tobacco smoking: a systematic review involving asbestos, crystalline silica and diesel engine exhaust emissions

Author (Year) Subjects Cases (sub-cohort) Follow-up NS/Exposed S/Exposed Interaction Estimation Interpretation
Additive Multiplicative Additive Multiplicative
Berry (1985) [24] M: 1250
F: 420
M: 64
F: 15
1971–1980 RR = 7.3 RR = 2.4 NA RAE = 3.0 (0.8-7.5) NA No
Liddell (2002) [26] M: 7279 M: 533 1904–1992 SMR = 0.62 SMR = 1.71 S = 1.1 (0.73-1.41) RAE = 1.69 (0.87-3.28) No No
Reid (2006) [23] M: 2550
F: 183
M: 132
F: 6
1979–2002 OR = 2.02 (0.61–6.72) OR = 1.64 (1.124–2.37) NA RAEm = 1.59 (0.12-20.50) NA No
Frost (2011) [25] M: 93966 M: 1768 1971–2005 RR = 1.6 (0.6–4.2) RR = 26.2 (13.0–53.1) S = 1.4 (1.2-1.6) V = 0.9 (0.3-2.4) Positive No
Wang (2012) [22] M: 1539 M: 50 1981–2006 SMR = 1.79 (0.49-6.51) SMR = 5.45 (4.11-7.22) NA RAE = 0.52 (0.07-1.11) NA No
Wang (2012) [28] M: 577 M: 53 1972–2008 HR = 7.52 (0.90-62.79) HR = 17.35 (2.38-126.57) S = 1.41 (0.73-3.99) NA No NA
Offermans (2014) [27] M: 2324 M: 2107 1986–2003 HR = 1.79 (1.04–3.08) HR = 10.21 (7.26–14.35) RERI = 1.94 (0.13-4.89) IT P = 0.50 No No
  1. M Males, F Females, S smokers, NS non-smokers, S Synergy Index, RERI Relative Excess Risk due to Interaction, V Multiplicativity Index, RAE Relative Asbestos Effect, RAE m the Modified Relative Asbestos Effect