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Table 2 Results of cohort studies included in the systematic review for the asbestos-smoking interaction

From: Absence of multiplicative interactions between occupational lung carcinogens and tobacco smoking: a systematic review involving asbestos, crystalline silica and diesel engine exhaust emissions

Author (Year)

Subjects

Cases (sub-cohort)

Follow-up

NS/Exposed

S/Exposed

Interaction Estimation

Interpretation

Additive

Multiplicative

Additive

Multiplicative

Berry (1985) [24]

M: 1250

F: 420

M: 64

F: 15

1971–1980

RR = 7.3

RR = 2.4

NA

RAE = 3.0 (0.8-7.5)

NA

No

Liddell (2002) [26]

M: 7279

M: 533

1904–1992

SMR = 0.62

SMR = 1.71

S = 1.1 (0.73-1.41)

RAE = 1.69 (0.87-3.28)

No

No

Reid (2006) [23]

M: 2550

F: 183

M: 132

F: 6

1979–2002

OR = 2.02 (0.61–6.72)

OR = 1.64 (1.124–2.37)

NA

RAEm = 1.59 (0.12-20.50)

NA

No

Frost (2011) [25]

M: 93966

M: 1768

1971–2005

RR = 1.6 (0.6–4.2)

RR = 26.2 (13.0–53.1)

S = 1.4 (1.2-1.6)

V = 0.9 (0.3-2.4)

Positive

No

Wang (2012) [22]

M: 1539

M: 50

1981–2006

SMR = 1.79 (0.49-6.51)

SMR = 5.45 (4.11-7.22)

NA

RAE = 0.52 (0.07-1.11)

NA

No

Wang (2012) [28]

M: 577

M: 53

1972–2008

HR = 7.52 (0.90-62.79)

HR = 17.35 (2.38-126.57)

S = 1.41 (0.73-3.99)

NA

No

NA

Offermans (2014) [27]

M: 2324

M: 2107

1986–2003

HR = 1.79 (1.04–3.08)

HR = 10.21 (7.26–14.35)

RERI = 1.94 (0.13-4.89)

IT P = 0.50

No

No

  1. M Males, F Females, S smokers, NS non-smokers, S Synergy Index, RERI Relative Excess Risk due to Interaction, V Multiplicativity Index, RAE Relative Asbestos Effect, RAE m the Modified Relative Asbestos Effect