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Table 1 Risk factors for death in TB patients

From: Risk factors for mortality in TB patients: a 10-year electronic record review in a South African province

Variables

N = 30 991 n (%)

Univariate results OR (95% CI)

Full adjusted model – died and default/LTFU AOR (95% CI)

Full adjusted model – died only AOR (95% CI)

Males AOR (95% CI)

Females AOR (95% CI)

Gender

Female (Ref)

13 834 (44.64)

1

1

1

-

-

Male

17 157 (55.30)

1.0 (0.9–1.2)

0.8 (0.6–1.0)

0.8 (0.7–0.9)

-

-

Age (years)

≤7 (Ref)

943 (3.04)

1

1

1

1

1

8–17

472 (1.52)

1.4 (1.2–1.6)

1.9 (1.6–2.3)

2.0 (1.5–2.7)

2.0 (1.3–3.2)

2.0 (1.8–2.2)

18–49

23 266 (75.07)

4.1 (3.8–4.5)

4.0 (3.0–5.4)

5.8 (4.0–8.4)

6.4 (4.5–9.0)

5.3 (3.6–7.9)

50–64

5 094 (16.44)

5.2 (4.1–6.6)

4.4 (2.9–6.5)

7.7 (4.6–12.7)

9.0 (6.0–13.4)

6.8 (3.9–12.1)

≥65

1 216 (3.92)

8.4 (7.2–9.9)

7.5 (6.1–9.2)

14.4 (10.3–20.2)

13.8 (10.1–18.9)

14.4 (9.9–21.0)

HIV status

Negative (Ref)

1 787 (5.77)

1

1

1

1

1

Positive

10 748 (34.68)

2.2 (2.0–2.5)

1.6 (1.4–1.9)

1.8 (1.6–2.1)

2.4 (2.1–2.8)

1.9 (1.7–2.1)

Unknown

18 456 (59.55)

2.8 (2.6–3.0)

1.9 (1.7–2.1)

2.4 (2.2–2.5)

2.8 (2.5–3.1)

2.4 (2.2–2.6)

Pre-treatment sputum smear result

Smear + (Ref)

12 047 (38.87)

1

1

1

1

1

Smear -

7 375 (23.80)

1.5 (1.4–1.7)

1.3 (1.2–1.5)

1.4 (1.3–1.6)

1.4 (1.2–1.6)

1.5 (1.3–1.6)

No result

11 569 (37.33)

1.6 (1.4–1.8)

1.9 (1.4–2.6)

2.1 (1.4–3.2)

2.3 (1.5–3.4)

2.0 (1.3–3.1)

Treatment category

New (Ref)

24 587 (79.34)

1

1

1

1

1

Retreatment

6 404 (20.66)

1.4 (1.3–1.5)

1.4 (1.3–1.5)

1.3 (1.2–1.4)

1.3 (1.2–1.4)

1.3 (1.2–1.4)

Disease classification

Both (Ref)

776 (2.50)

1

1

1

1

1

PTB

23 210 (74.89)

1.3 (1.0–1.5)

1.0 (1.0–1.1)

1.0 (0.9–1.1)

1.0 (0.8–1.2)

1.0 (0.7–1.4)

EPTB

7 005 (22.60)

0.8 (0.6–0.9)

1.1 (0.9–1.3)

1.0 (0.8–1.2)

1.0 (0.8–1.1)

1.0 (0.7–1.3)

Treatment delay

≤14 days (Ref)

12 820 (41.37)

1

1

1

1

1

>14 days

3 244 (10.47)

1.0 (0.9–1.1)

0.9 (0.9–1.0)

0.9 (0.9–1.0)

0.9 (0.8–1.0)

0.9 (0.9–1.0)

Missing

14 927 (48.17)

1.4 (1.3–1.5)

1.1 (0.9–1.2)

1.0 (0.9–1.2)

1.0 (0.9–1.1)

1.1 (0.9–1.3)

HIV status x gendera

Male x HIV positive

-

-

1.23 (1.15–1.32)

1.33 (1.26–1.41)

-

-

Male x HIV unknown

-

-

1.16 (1.09–1.25)

1.20 (1.15–1.25)

-

-

  1. OR odds ratio; AOR adjusted odds ratio; CI confidence interval
  2. aAdjusted for HIV status, gender and HIV status x gender interaction